Antituberculosis Agents
Mostrando 1-12 de 28 artigos, teses e dissertações.
-
1. Dormancy models for
Mycobacterium tuberculosis : A minireviewDormancy models for
Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimyBraz. J. Microbiol.. Publicado em: 2015-09
-
2. DeterminaÃÃo do perfil de pacientes e avaliaÃÃo do tratamento da tuberculose latente em candidatos ao uso de bloqueadores do TNFâα no Hospital UniversitÃrio Walter CantÃdio (HUWC/UFC). / Determining of the profile of patients and evaluation of treatment of latent tuberculosis infection in candidates for the use of tumor necrosis factor-alpha blockers in University Hospital Walter CantÃdio (HUWC/UFC).
A introduÃÃo na prÃtica clÃnica dos agentes bloqueadores do TNF-α representou uma revoluÃÃo no tratamento das doenÃas inflamatÃrias crÃnicas: artrite reumatÃide (AR), espondilite anquilosante (EA), doenÃa de Crohn (DC) e psorÃase. Desde entÃo, seu uso tem sido ampliado, contudo essa terapia de alto custo econÃmico elevou o risco de desenvo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/03/2010
-
3. ESTUDO EPIDEMIOLÃGICO E PERFIL DE RESISTÃNCIA ÃS DROGAS ANTI-TUBERCULOSE EM PACIENTES CO-INFECTADOS COM TB/HIV EM HOSPITAL DE REFERÃNCIA EM FORTALEZA-CEARÃ. / EPIDEMIOLOGICAL STUDY AND RESISTANCE PATTERNS TO THE ANTI-TUBERCULOSIS DRUGS IN MYCOBACTERIA AND HIV CO-INFECTED PATIENTS IN A REFERENCE HOSPITAL IN FORTALEZA, CEARÃ.
The HIV infection and the tuberculosis (TB) are together the main causes of death for infectious agents in the world, being approximately 13 million people infected with both causative agents. The HIV-infected individuals show increased susceptibility for active tuberculosis, being the imunosupression caused by the virus the main risk factor for the developm
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2007
-
4. Case report of lymph nodal, hepatic and splenic tuberculosis in an HIV-positive patient
We describe a case of a male patient, 38 years old, HIV-positive (most recent CD4 count about 259/mm³), with abdominal pain, nausea, vomiting, anorexia, weight loss, and vespertine high fever with chills. His hemogram showed normocytic and normochromic anemia, with a high erythrocyte sedimentation rate (ESR) and gross granulations in the neutrophils. Transa
Brazilian Journal of Infectious Diseases. Publicado em: 2006-04
-
5. Postantibiotic Effects of Antituberculosis Agents Alone and in Combination
The postantibiotic effects (PAEs) of seven antimycobacterial agents, tested at their respective peak concentrations in serum alone and in different combinations, against Mycobacterium tuberculosis ATCC 27294 were studied with a radiometric culture system in parallel with the viable count method. Rifampin gave the longest PAE (67.8 h) among the drugs used alo
American Society for Microbiology.
-
6. Green Fluorescent Protein Reporter Microplate Assay for High-Throughput Screening of Compounds against Mycobacterium tuberculosis
An optimal assay for high-throughput screening for new antituberculosis agents would combine the microplate format and low cost of firefly luciferase reporter assays and redox dyes with the ease of kinetic monitoring inherent in the BACTEC system. The green fluorescent protein (GFP) of the jellyfish Aequorea victoria is a useful reporter molecule which requi
American Society for Microbiology.
-
7. Improved Green Fluorescent Protein Reporter Gene-Based Microplate Screening for Antituberculosis Compounds by Utilizing an Acetamidase Promoter
The green fluorescent protein (GFP) gene offers many advantages as a viability reporter for high-throughput antimicrobial drug screening. However, screening for antituberculosis compounds by using GFP driven by the heat shock promoter, hsp60, has been of limited utility due to the low signal-to-noise ratio. Therefore, an alternative promoter was evaluated fo
American Society for Microbiology.
-
8. Antituberculosis activities of clofazimine and its new analogs B4154 and B4157.
In our efforts to develop new drugs for the treatment of tuberculosis, especially that caused by multidrug-resistant strains, we investigated clofazimine (CFM) and two of its analogs, B4154 and B4157, for their antituberculosis activities. Twenty M. tuberculosis strains were tested, including 16 drug-resistant strains (strains resistant to one or more antitu
-
9. Salicylate Reduces Susceptibility of Mycobacterium tuberculosis to Multiple Antituberculosis Drugs
Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-ami
American Society for Microbiology.
-
10. Suppression of adoptive antituberculosis immunity by normal recipient animals.
Adoptive immunity is poorly expressed in normal syngeneic mice. This phenomenon was studied by using experimental antituberculosis immunity as a model system representing pure cell-mediated immunity. Expression of adoptive immunity was facilitated by pretreating recipients with sublethal ionizing radiation (500 rads) or high doses (200 mg/kg) of cyclophospha
-
11. Clinical Concentrations of Thioridazine Kill Intracellular Multidrug-Resistant Mycobacterium tuberculosis
The phenothiazines chlorpromazine (CPZ) and thioridazine (TZ) have equal in vitro activities against antibiotic-sensitive and -resistant Mycobacterium tuberculosis. These compounds have not been used as anti-M. tuberculosis agents because their in vitro activities take place at concentrations which are beyond those that are clinically achievable. In addition
American Society for Microbiology.
-
12. Mutant Prevention Concentration as a Measure of Antibiotic Potency: Studies with Clinical Isolates of Mycobacterium tuberculosis†
The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluor
American Society for Microbiology.