Antisense Transcription
Mostrando 1-12 de 453 artigos, teses e dissertações.
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1. In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability
Small cell lung cancer (SCLC) is an aggressive disease, representing 15% of all cases of lung cancer, has high metastatic potential and low prognosis that urgently demands the development of novel therapeutic approaches. One of the proposed approaches has been the down-regulation of BCL2, with poorly clarified and controversial therapeutic value regarding SC
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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2. Identificação de perfis de expressão de RNAs codificadores e não codificadores de proteína como preditores de recorrência de câncer de próstata / Identification of protein-coding and non-coding RNA expression profiles as prognostic marker of prostate cancer biochemical recurrence
O câncer de próstata é o quinto tipo mais comum de câncer no mundo e o mais comum em homens. Fatores clínicos e anatomopatológicos atualmente usados na clínica não são capazes de distinguir entre a doença indolente e a agressiva. Existe uma grande necessidade de novos marcadores de prognóstico, a fim de melhorar o gerenciamento clínico de pacient
Publicado em: 2010
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3. Efeitos do pareamento no perfil de expressão gênica do parasita Schistosoma mansoni / Effects of pairing on the gene expression profiles of the parasite Schistosoma mansoni
Schistosomiasis is a chronic and debilitating disease. Schistosoma represents the only class of trematodes with a dioecious life. A continuous pairing with the male is essential for female sexual maturation. Adult females from uni-sexual infections are underdeveloped, have body atrophy and an immature reproductive system. To study the mechanisms involved in
Publicado em: 2010
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4. Effects of L1-ORF2 fragments on green fluorescent protein gene expression
The retrotransposon known as long interspersed nuclear element-1 (L1) is 6 kb long, although most L1s in mammalian and other eukaryotic cells are truncated. L1 contains two open reading frames, ORF1 and ORF2, that code for an RNA-binding protein and a protein with endonuclease and reverse transcriptase activities, respectively. In this work, we examined the
Genetics and Molecular Biology. Publicado em: 28/08/2009
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5. A proteina PGC-1a modula a expressão de interleucina-10 no figado : avaliação da sua interação com os fatores de transcrição NFkB e C-MAF / PGC-1a modulates interleukin-10 in the liver : interaction with the transcription factors NFkB and C-MAF
Interleukin-10 (IL-10) is an endogenous factor that restrains hepatic insulin resistance in diet-induced steatosis. Reducing IL-10 expression increases pro-inflammatory activity in the steatotic liver and worsens insulin resistance. Because in diet-induced steatosis the transcriptional co-activator PGC-1a plays a central role in the dysfunctional hepatocytic
Publicado em: 2009
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6. Uso de técnicas computacionais no estudo da transcrição e regulação gênica em Homo sapiens e Mus musculus / Use of computational methods to study the transcription and gene regulation in Homo sapiens and Mus musculus
Genes, nucleotide sequences necessary for the synthesis of functional molecules, are transcribed and regulated by extremely complex cellular and molecular processes. To understand when and in which tissues the genes are expressed, their functional isoforms, control regions and the factors involved in gene regulation is one of major challenges of modern molec
Publicado em: 2008
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7. Análise da expressão de RNAs não-codificadores intrônicos em tumores de mama / Gene expression analysis of intronic non-coding RNAs in breast tumors
O câncer de mama é o carcinoma que mais acomete mulheres no Brasil. Os tratamentos disponíveis são recomendados a partir da análise de fatores de prognóstico como a classificação pelo sistema TNM, tipo histológico, status de receptores hormonais e marcadores de proliferação tumoral. No entanto, a classificação dos tumores de mama é muito variá
Publicado em: 2008
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8. Identificação e análise de expressão de RNAs intrônicos não codificadores humanos / Identification and expression analysis of human intronic noncoding RNAs
In this work, we show large-scale studies of antisense noncoding RNAs transcribed from intronic regions of human genes. The correlation of expression levels of some intronic transcripts to the degree of tumor differentiation in prostate cancer points to the biological relevance of these messages in complex diseases such as cancer. We also evaluated the exist
Publicado em: 2007
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9. Regulação da expressão e ativação do fator de transcrição C-JUN no miocardio de ratos submetido a sobrecarga pressora aguda
The early expression of immediate early genes is a fundamental feature of myocardial hypertrophy. The immediate early gene c-jun codifies a transcription factor that has been assigned to be an important regulator of the hypertrophic response in cardiac myocytes. In the present study we investigated whether pressure overload or phenylephrine treatment stimula
Publicado em: 2003
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10. Production and characterization of gum operon mutants of Xylella fastidiosa cvc strain. / Produção e caracterização de mutantes do operon gum de Xylella fastidiosa.
Xylella fastidiosa is a fastidious, xylem restricted, gram.negative bacteria, that causes several economically important diseases as Pierce s disease of grapevine in USA and the Citrus Variegated Chlorosis (CVC) in Brasil. CVC affects severely the São Paulo State citriculture jeopardizing thousands of jobs and millions of dollars of incomes. The genome sequ
Publicado em: 2003
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11. Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation
We have used the FANTOM2 mouse cDNA set (60,770 clones), public mRNA data, and mouse genome sequence data to identify 2481 pairs of sense–antisense transcripts and 899 further pairs of nonantisense bidirectional transcription based upon genomic mapping. The analysis greatly expands the number of known examples of sense–antisense transcript and nonant
Cold Spring Harbor Laboratory Press.
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12. Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.
We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells), our findings indicate that antisense tr