Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.
AUTOR(ES)
van Duin, M
RESUMO
We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells), our findings indicate that antisense transcription in the ERCC-1-RAD10 gene regions represents an evolutionarily conserved feature.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=362600Documentos Relacionados
- Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage.
- Stable and specific association between the yeast recombination and DNA repair proteins RAD1 and RAD10 in vitro.
- Stable and Specific Association between the Yeast Recombination and DNA Repair Proteins RAD1 and RAD10 In Vitro
- Molecular cloning and characterization of the yeast RAD10 gene and characterization of RAD10 protein in E. coli
- Molecular cloning and characterization of the yeast RAD10 gene and expression of RAD10 protein in E. coli.
