Antiparasitic
Mostrando 1-12 de 200 artigos, teses e dissertações.
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1. Tandem Synthesis of Furanaphthoquinones via Enamines and Evaluation of Their Antiparasitic Effects against Trypanosoma cruzi
Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant structural heterogeneity and bioactivities. In this work, it was synthesized a series of furanaphthoquinones through a tandem reaction between lawsone (8) and cyclic ketones in the presence of morpholine. This strategy provides an efficient and general method for synthesizing f
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Antileishmanial Acetylene Fatty Acid and Acetogenins from Seeds of Porcelia macrocarpa
In the present work five acetylene derivatives (1-5), including three unknowns (1, 3 and 4), were isolated from seeds of Porcelia macrocarpa (Annonaceae). The structures of isolated compounds were determined as docos-13-yn-21-enoic acid (1), 3-hydroxy-4-methylene-2-(eicos-11’-yn-19’-enyl)but-2-enolide (2), 3-hydroxy-4-methylene-2-(octadec-9’-yn-17’-e
J. Braz. Chem. Soc.. Publicado em: 2021-02
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3. Dereplication of Aporphine Alkaloids by UHPLC-HR-ESI-MS/MS and NMR from Duguetia lanceolata St. -Hil (Annonaceae) and Antiparasitic Activity Evaluation
Although the genus Duguetia is well known for producing alkaloids as chemical constituents, there are no reports of alkaloids identified in the species D. lanceolata. Thus, aiming to identify the chemical composition of this species, the dereplication of alkaloidic phase was performed by use of ultra-high performance liquid chromatography high resolution ele
J. Braz. Chem. Soc.. Publicado em: 2020-09
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4. Phytochemical Analysis, Multi-Element Composition and Biological Activities of Extracts and Lupenone from Albizia inundata (Mart.) Barneby & J.W.Grimes
In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimosoideae), were tested. In addition, the multi-element composition of the leaves, bark and stems (heartwood) of A. inundata was evaluated using inductively coupled plasma optical emission spectrometry (ICP OES). Lupenone was isolated in the petroleum ether extract o
J. Braz. Chem. Soc.. Publicado em: 2020-09
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5. Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity
Qualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of bo
J. Braz. Chem. Soc.. Publicado em: 2020-07
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6. Disposal of animal healthcare services waste in southern Brazil: One Health at risk
RESUMO A pecuária brasileira está em franca expansão, porém associada ao uso de medicamentos veterinários que podem ser considerados contaminantes emergentes. Este estudo objetivou caracterizar o descarte dos Resíduos de Serviços de Saúde Animal (RSSA), especialmente dos medicamentos veterinários, além de identificar os medicamentos mais usados no
Saúde debate. Publicado em: 13/01/2020
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7. An eco-friendly method for extraction and quantification of flavonoids in Dysphania ambrosioides
ABSTRACT Dysphania ambrosioides (L.) Mosyakin and Clemants (Syn: Chenopodium ambrosioides L.), Amaranthaceae, is a plant with antibacterial, antifungal, antioxidant, antiparasitic and antitumor properties that is commonly used in Brazilian folk medicine. In this work we performed the optimization of ultrasound-assisted extraction of flavonoids in the aerial
Rev. bras. farmacogn.. Publicado em: 27/05/2019
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8. Performance and Serum Biochemical Profile of Broiler Chickens Supplemented with Piper Cubeba Ethanolic Extract
ABSTRACT Piper cubeba is an Asian pepper used in popular medicine for its known antimicrobial, antiparasitic, and anti-inflammatory actions. The study evaluated the effects of dietary inclusion of Piper cubeba ethanolic extract (PE) as a replacement for anantibiotic growth promoter (AGP) on the performance and biochemical serum profile of 1- to 21-d-old broi
Braz. J. Poult. Sci.. Publicado em: 18/04/2019
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9. Complete Resolution of Electrocardiographic Changes Induced by Acute Chagas Myocarditis
Abstract We present a case of a female adolescent with severe acute Chagas myocarditis, acquired by oral transmission in an endemic area in the Brazilian western Amazon, who had electrocardiographic changes normalized after empirical treatment with the antiparasitic drug benznidazole combined with conventional treatment for severe heart failure.
Int. J. Cardiovasc. Sci.. Publicado em: 07/03/2019
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10. Ivermectin and albendazole withdrawal period in goat milk
RESUMO Objetivou-se determinar o perfil de excreção de resíduos de albendazole e ivermectina em leite de cabras submetidas a tratamento antiparasitário. Vinte e quatro cabras sem padrão racial definido (SPRD), lactantes, pluríparas, criadas extensivamente em pastagem nativa foram tratadas com albendazole ou ivermectina, via oral. As amostras de leite f
Rev. bras. saúde prod. anim.. Publicado em: 04/02/2019
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11. Synthesis of leading chalcones with high antiparasitic, against Hymenolepis nana, and antioxidant activities
The hymenolepiosis by Hymenolepis nana is a major public health problem in developing countries, and the commercial drugs against this parasitosis are not enough effective. The combination of antiparasitic and antioxidant agents has improved the treatment of some parasitoses. Thus, the development of new cestocidal and antioxidant agents to treat the hymenol
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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12. Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach
Abstract Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described for the first time the activity of a potent antiarrhythmic, amiodarone (AMD), against L. (L.)infantu
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018