Antimony
Mostrando 1-12 de 160 artigos, teses e dissertações.
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1. Multivariate Optimization Applied to the Synthesis of Meglumine Antimoniate with Low Levels of Trivalent Antimony
Meglumine antimoniate (MA) is a pentavalent antimony (SbV) drug recommended for the treatment of leishmaniasis. It is known that the trivalent antimony (SbIII) present as a residue in MA contributes to the drug side effects. In this article, multivariate optimization was used in the synthesis of MA in order to obtain a drug with low levels of SbIII. Four var
J. Braz. Chem. Soc.. Publicado em: 2021-08
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2. Speciation of Antimony in Injectable Leishmanicidal Drugs by Lowering Citric Acid Concentration Used in Hydride Generation Atomic Absorption Spectrometry Analysis
This study proposes a procedure for speciation of antimony by hydride generation atomic absorption spectrometry in pentavalent antimony drugs. The SbIII content was determined by selective generation of SbH3 in medium with higher SbV concentration using 4 to 20-fold lower citric acid solutions than recommended in the available literature. The multivariate op
J. Braz. Chem. Soc.. Publicado em: 2021-01
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3. Oncologia Ocular no Brasil: Qual o nosso passado, presente e futuro?
This study proposes a procedure for speciation of antimony by hydride generation atomic absorption spectrometry in pentavalent antimony drugs. The SbIII content was determined by selective generation of SbH3 in medium with higher SbV concentration using 4 to 20-fold lower citric acid solutions than recommended in the available literature. The multivariate op
Arq. Bras. Oftalmol.. Publicado em: 2021-01
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4. Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of this study was to characterise antimony (Sb)-resistant
Mem. Inst. Oswaldo Cruz. Publicado em: 15/08/2019
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5. Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis-infected BALB/c mice
Abstract Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side effects and resistant cases. Their pharmacokinetics remain largely unexplored. This study aimed to investigate the pharmacokinetic profile of meglumine anti
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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6. Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
Abstract: Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is observed in almost half of cases. Disseminated leishmaniasis
An. Bras. Dermatol.. Publicado em: 2019-02
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7. Ascorbate peroxidase overexpression protects Leishmania braziliensis against trivalent antimony effects
Ascorbate peroxidase (APX) is a redox enzyme of the trypanothione pathway that converts hydrogen peroxide (H2O2) into water molecules. In the present study, the APX gene was overexpressed in Leishmania braziliensis to investigate its contribution to the trivalent antimony (SbIII)-resistance phenotype. Western blot results demonstrated that APX-overexpressing
Mem. Inst. Oswaldo Cruz. Publicado em: 14/11/2018
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8. Is Visceral Leishmaniasis the same in HIV-coinfected adults?
ABSTRACT Introduction: Visceral Leishmaniasis is the most severe form of disease caused by the Leishmania donovani complex, with significant morbidity and mortality in developing countries. Worse outcomes occur among HIV-positive individuals coinfected with Leishmania. It is unclear, however, if there are significant differences on presentation between Visc
Braz J Infect Dis. Publicado em: 2018-03
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9. Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil
BACKGROUND Treatment-refractory visceral leishmaniasis (VL) has become an important problem in many countries. OBJECTIVES We evaluated the antimony-resistance mechanisms of Leishmania infantum isolated from VL patients refractory or responsive to treatment with pentavalent antimony. METHODS Strains isolated from antimony-refractory patients (in vitro anti
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-02
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10. Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment
BACKGROUND Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES This study aims to validate the standard op
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-02
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11. Analytical Strategies for Determination and Environmental Impact Assessment of Inorganic Antimony Species in Natural Waters Using Hydride Generation Atomic Fluorescence Spectrometry (HG AFS)
This study proposes an optimized procedure for the determination of inorganic antimony species in natural waters using hydride generation atomic fluorescence spectrometry (HG AFS) and continuous flow system. The variables of the hydride generation system, such as pre-reduction time, hydrochloric acid concentration and sodium tetrahydroborate concentration, w
J. Braz. Chem. Soc.. Publicado em: 2018-01
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12. Epidemiological aspects of American cutaneous leishmaniasis (ACL) in an endemic area of forest extractivist culture in western Brazilian Amazonia
ABSTRACT The study sought to analyze clinical and epidemiological aspects of cutaneous leishmaniasis (CL) in Xapuri, Acre, Brazil. Data from 2008 to 2014 registered in the notification records of the disease of the Information System of the Complaints of Notification (SINAN), and the data of the Information Department of the Unified Health System (DATASUS) a
Rev. Inst. Med. trop. S. Paulo. Publicado em: 13/04/2017