Antimony
Mostrando 13-24 de 160 artigos, teses e dissertações.
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13. Phenotypic diversity and selection maintain Leishmania amazonensis infectivity in BALB/c mouse model
Leishmania are protozoan parasites that show remarkable diversity, as revealed by the various clinical forms of leishmaniasis, which can range from mild skin lesions to severe metastatic cutaneous/mucosal lesions. The exact nature and extent of Leishmania phenotypic diversity in establishing infection is not fully understood. In order to try to understand so
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-01
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14. PANCREATIC TOXICITY AS AN ADVERSE EFFECT INDUCED BY MEGLUMINE ANTIMONIATE THERAPY IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS
SUMMARY American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with m
Rev. Inst. Med. trop. S. Paulo. Publicado em: 22/09/2016
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15. Multivariate optimization of a method for antimony determination by hydride generation atomic fluorescence spectrometry in hair samples of patients undergoing chemotherapy against Leishmaniasis
ABSTRACT A method was developed for determination of total antimony in hair samples from patients undergoing chemotherapy against Leishmaniasis based on the administration of pentavalent antimonial drugs. The method is based on microwave assisted digestion of the samples in a pressurized system, reduction of Sb5+ to Sb3+ with KI solution (10% w/v) in ascorbi
An. Acad. Bras. Ciênc.. Publicado em: 25/08/2016
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16. Antimonial drugs entrapped into phosphatidylserine liposomes: physicochemical evaluation and antileishmanial activity
Abstract: INTRODUCTION: Leishmaniasis is a disease caused by the protozoan Leishmania that resides mainly in mononuclear phagocytic system tissues. Pentavalent antimonials are the main treatment option, although these drugs have toxic side effects and high resistance rates. A potentially alternative and more effective therapeutic strategy is to use liposom
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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17. Noteworthy Method for Direct Determination of SbIII and Total Inorganic Antimony in Natural Waters
A procedure was developed for the direct determination of SbIII and total inorganic Sb in water samples by hydride generation atomic absorption spectrometry (HG AAS), without pre-reduction of SbV. The NaBH4 concentration was maintained at 0.4% (m/v) to perform the selective generation of stibine from SbIII and online stibine generation was carried out with 5
J. Braz. Chem. Soc.. Publicado em: 2015-05
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18. Poor response to azithromycin in cutaneous leishmaniasis leading to a premature interruption of a multicentric phase III clinical trial in Brazil
Introduction Parenteral antimony-based compounds are still the standard of care for cutaneous leishmaniasis (CL) treatment in many countries, despite their high toxicity. Previous studies showed that oral azithromycin could be an option for CL tre
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-12
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19. Varicella zoster virus reactivation during or immediately following treatment of tegumentary leishmaniasis with antimony compounds
Antimony compounds are the cornerstone treatments for tegumentary leishmaniasis. The reactivation of herpes virus is a side effect described in few reports. We conducted an observational study to describe the incidence of herpes zoster reactivation during treatment with antimony compounds. The global incidence of herpes zoster is approximately 2.5 cases per
Mem. Inst. Oswaldo Cruz. Publicado em: 03/07/2014
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20. Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate
Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tis
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-07
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21. Velocidad de corrosión de una aleación base plomo en una solución de ácido sulfúrico a diferentes temperaturas
Car batteries are not only affected by their use and wear but also by other factors such as electrolyte concentration, water loss and temperature that can be exposed, the latter being the most influential factor causing an increase in the corrosion rate of lead alloys (battery components), and affecting their service time. Therefore, for the industry of auto
Matéria (Rio J.). Publicado em: 2014-06
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22. Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB/c mice
Pentavalent antimonials such as meglumine antimoniate (MA) are the primary treatments for leishmaniasis, a complex disease caused by protozoan parasites of the genus Leishmania . Despite over 70 years of clinical use, their mechanisms of action, toxicity and pharmacokinetics have not been fully elucidated. Radiotracer studies performed on animals have the po
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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23. Removal of mercury, antimony, cadmium and lead from aqueous solution using 1,3,5-trithiane as an adsorbent
Neste trabalho, utilizou-se 1,3,5-tritiano (TT) na remoção dos íons Hg(II), Sb(III), Cd(II) e Pb(II) em soluções aquosas. A influência das condições de remoção tais como pH, tempo de contato e concentração inicial de TT na capacidade de ligação dos íons foi testada. As capacidades de adsorção máxima para os íons Hg(II), Sb(III), Cd(II) e P
J. Braz. Chem. Soc.. Publicado em: 2013-05
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24. Complexos metálicos de hidrazonas, tiossemicarbazonas e lapachol: atividade farmacológica e avaliação de relações estrutura-atividade
The present work comprises the synthesis and characterization of metal compounds with bioactive ligands and the study of their pharmacological profile. Anti-inflammatory, antimicrobial, antiparasitic and antitumor drug candidates were designed. Complex [Zn(LASSBio-466)H2O]2 was synthesized with salicylaldehyde-2-chlorobenzoyl hydrazone (H2LASSBio-466), while
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012