Antimalarial Efficacy
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Therapeutic failure after regimen with artemether-lumefantrine combination therapy: a report of three cases in Benin City, Nigeria
Abstract Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for the treatment of uncomplicated malaria. Currently, there appears to be a downward trend in the efficacy of ACT in some parts of sub-Saharan Africa because some patients have been positive for Plasmodium parasite 3 days after artemether-lumefantrine treatm
Rev. Soc. Bras. Med. Trop.. Publicado em: 10/10/2019
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2. Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?
In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that h
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-08
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3. The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/k
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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4. Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
Praziquantel (PZQ) is currently the only drug widely used for the treatment of schistosomiasis, but the antimalarial drug mefloquine (Mef) possesses interesting antischistosomal properties. Combination therapy with these two drugs has been suggested as a strategy for transmission control, as PZQ is active against adult worms and Mef is active against schisto
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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5. Desenvolvimento e avaliação da atividade e farmacocinética de nanopartículas lipídicas sólidas contendo a associação de quinina e doxiciclina / Development and evaluation of the activity and pharmacokinetics of solid lipid nanoparticles loaded with the association of Quinine and Doxycycline
Malaria is one of the most devastating tropical diseases caused by intracellular protozoan parasites of the genus Plasmodium. More than 3 billion people live in malarial endemic regions. Five species of Plasmodium (falciparum, vivax, ovale, malariae and knowlesi) cause disease in humans and infection with P. falciparum, the most deadly of these parasites, re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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6. Eletrophoretic and spectrometric characterization of Cinchona extracts of use phytoterapic and cosmetic / Caracterização eletroforética e espectrométrica de extratos de Cinchona de uso fitoterápico e cosmético
Every year, malaria kills about one million people. According to OMS, 3.3 billion people, half of the world population, are exposed to the disease, mostly in underdeveloped countries. The pharmaceuticals used in the treatment of malaria include: chloroquine, primaquine, quinine, mefloquine, doxyclyne, clindamicina and artemisin. The increased resistance of t
Publicado em: 2010
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7. Reduced protective effect of Plasmodium berghei immunization by concurrent Schistosoma mansoni infection
Studies on concomitant schistosomiasis and human and experimental malaria have shown a variation in the immunospecific response, as well as an increase in the severity of both parasitoses. In the present study, a murine co-infection model was used to determine the effects of a co-infection with Schistosoma mansoni and Plasmodium berghei on the protective imm
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-11
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8. Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment
Chloroquine (CQ) resistance in Plasmodium falciparum contributes to increasing malaria-attributable morbidity and mortality in Sub-Saharan Africa. Despite a change in drug policy, continued prescription of CQ did not abate. Therefore the therapeutic efficacy of CQ in uncomplicated falciparum malaria patients was assessed in a standard 28-day protocol in 116
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-02
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9. Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vi
Memórias do Instituto Oswaldo Cruz. Publicado em: 10/05/2007
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10. Avaliação da eficácia e farmacocinética de nanocápsulas poliméricas de quinina em ratos infectados com plasmodium berghei / Efficacy and pharmacokinetics of polymeric nanoparticles containing quinine in Plamodium berghei infected rats
Objetivos: Desenvolver, caracterizar e avaliar a eficácia in vivo e o perfil farmacocinético de suspensões de nanocápsulas (NC) poliméricas contendo quinina (QN). Metodologia: As NC-QN foram preparadas através de nanoprecipitação com diferentes concentrações de QN: 2 (NC2-QN), 3 (NC3-QN) e 4 mg/mL (NC4-QN). A NC4-QN também foi revestida com quitos
Publicado em: 2007
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11. Assessment of Therapeutic Response of Plasmodium vivax and Plasmodium falciparum to Chloroquine in a Malaria Transmission Free Area in Colombia
In order to determine the frequency of therapeutic failures to chloroquine (CQ) in patients with malaria due to either Plasmodium falciparum or P. vivax, and to explore the usefulness of a malaria-free city as a sentinel site to monitor the emergence of drug resistance, 53 patients (44 infected with P. vivax and 9 with P. falciparum) were evaluated at the La
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-06
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12. Cultivo in vitro de Artemisia annua L. para a produção de artemisinina
Malaria, one of tbe major public health poblems in tropical countries, has been counteracted by syntbetic drogs such as chloroquine and their derivatives, presenting serious side effects. In addition their efficacy is affected mainly by the resistance of the malaria causing agent to these drugs. A plant extract from Artemisia annua, containing artemisinin, h
Publicado em: 1996