Antigens Immunology
Mostrando 1-12 de 48 artigos, teses e dissertações.
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1. Recombinant vaccines and the development of new vaccine strategies
Vaccines were initially developed on an empirical basis, relying mostly on attenuation or inactivation of pathogens. Advances in immunology, molecular biology, biochemistry, genomics, and proteomics have added new perspectives to the vaccinology field. The use of recombinant proteins allows the targeting of immune responses focused against few protective ant
Braz J Med Biol Res. Publicado em: 2012-12
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2. Influence of culture medium on the production of eif antigen from Leishmania chagasi in recombinant Escherichia coli
With the advent of recombinant DNA technology, recombinant protein expression has become an important tool in the study of the structure, function and identification of new proteins, especially those with therapeutic functions. Escherichia coli has been the predominant prokaryote used in genetic engineering studies due to the abundance of information about i
Braz. J. Microbiol.. Publicado em: 2011-12
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3. Efeito da sílica nanoestruturada SBA-15 na apresentação antigênica e na resposta imune. / Effect of nanostructured silica SBA-15 in antigen presentation and immune response.
A sílica SBA-15 devido às suas propriedades físico-química e estrutural tem demonstrado efeito adjuvante, carreando, protegendo e liberando antígenos. Nesse estudo avaliou-se o seu efeito sobre a atividade fagocítica de macrófagos; no recrutamento de células para órgãos linfóides; na expressão de moléculas MHC de classe II e co-estimuladoras pel
Publicado em: 2010
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4. Transfusão de plaquetas: do empirismo ao embasamento científico
Despite major advances in Brazilian blood transfusion therapy with a growing number of scientific publications, an increased number of repeat donors and a decline in serological ineligibility, a lack of conformity in the application of pre-transfusion tests that may compromise transfusion safety is still observed at transfusion agencies in the fringes of the
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2010
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5. Development of a therapeutic vaccine against HPV16 / Desenvolvimento de vacina terapêutica contra HPV16
Cervical cancer is the second most common cancer among women worldwide. Most cases (83%) occur in developing countries, where they are found in relatively advanced stages and, consequently, the median survival is about 49% after five years. Therefore, an effective vaccine against HPV infections can lead to control of cancer of the cervix. Although preventabl
Publicado em: 2010
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6. Study of regulatory and proinflammatory factors in chronic idiopathic urticaria and in vitro immunomodulatory effect of statins / Estudo dos fatores regulatórios e pró-inflamatórios na urticária crônica idiopática e efeito imunomodulatório in vitro das estatinas
INTRODUCTION: Chronic Idiopathic Urticaria (CIU) is a disease triggered by degranulation of basophils and mast cells with consequent histamine release and the CIU immunological profile is not well established. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, also display a broad immunomodulatory property. Statins have been studied in seve
Publicado em: 2010
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7. Atividade acaricida contra ácaros Dermatophagoides pteronyssinus e D. farinae (Pyroglyphidae) de produto contendo óleos essenciais de Lavadula officinalis e Mentha piperita (Labiatae) / Acaricide activity against mite Dermatophagoides pteronyssinus and D. farinae (Pyroglyphidae) of na herbal product containg essential oils from Lavadula officinalis and Mentha piperita (Labiatae)
House dust mites (HDM) are the greatest source of indoor allergens in Brazil, being closely implicated in respiratory allergic diseases such as asthma and rhinitis. In dwellings, HDM allergens are mainly found on mattresses, sofas and rug surfaces, where several methods such as mattress-covers and acaricides, can be used to control indoor mite infestation. T
Publicado em: 2009
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8. Evidências sorológicas e experimentais da resposta autoimune humoral contra a retina em uveites causada por Toxoplasma gondii / Experimental and serological evidence of humoral autoimmune response against retina in Toxoplasma gondii uveitis
Ocular toxoplasmosis is attributed to the parasite, but autoimmunity could have a role in this process. Human sera, positive of anti-T. gondii IgG, show high levels of anti-retina IgG, measured by several antigens, as compared to T. gondii seronegative samples. Sera from patients with uveitis from other origins also had higher anti-retina abs levels. Challen
Publicado em: 2008
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9. Evaluation of the effect of TNF-alpha inhibitors in the in vitro immune response to Mycobacterium tuberculosis antigens in patients with psoriasis / Avaliação do efeito do bloqueio de Fator de Necrose Tumoral alfa (TNF-) na resposta imune in vitro aos antígenos de Mycobacterium tuberculosis em pacientes com psoríase
O Fator de Necrose Tumoral-alfa (TNF-alfa) possui um importante papel na imunopatogênese da psoríase e agentes biológicos, como os inibidores de TNF-alfa, têm apresentado bons resultados no tratamento desta. No entanto, estes agentes foram associados ao aumento de casos de reativação de tuberculose entre os pacientes que os utilizaram. Este estudo foi
Publicado em: 2008
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10. Anaplasma marginale : análise da variabilidade do gene msp1 a e avaliação imunogênica da vacina de DNA contendo genes para MSP1a, MSP1b e MSP5 em camundongos BALB/c
Anaplasma marginale is an important tick-transmitted rickettsial pathogen of cattle that invades and multiplies within erythrocytes, causing severe hemolytic anemia during acute infection. Immunization with purified outer membrane proteins (OMP) induces protection against acute A. marginale disease. Of 21 OMP described six major surface proteins (MSPs 1a, 1b
Publicado em: 2007
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11. "Determinação de alvos antigênicos na doença reumática cardíaca utilizando phage display" / Identification of molecular markers involved in the pathogenesis of rheumatic heart disease by phage display
Rheumatic heart disease (RHD) patients develop valvar lesions with CD4+ T lymphocytes infiltrating the heart. Molecular mimicry between streptococcal and cardiac proteins recognized by these T cells may explain these auto-aggressive lesions. In the present work we used a Phage Display peptide library to identify cardiac antigens which could be recognized by
Publicado em: 2006
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12. Proteção imunológica contra a formação de cistos cerebrais em camundongos vacinados pela via nasal com proteínas recombinates de Toxoplasma gondii
Toxoplasma gondii is a protozoan parasite which can invade and reside in a wide range of host cells. It can infect all warm-blooded animals, including human being. Parasite invasion is associated with protein secretion from three organelles: micronemes, rhoptries and dense granules. These excreted/secreted antigens were highly immunogenic in humans and roden
Publicado em: 2006