Evidências sorológicas e experimentais da resposta autoimune humoral contra a retina em uveites causada por Toxoplasma gondii / Experimental and serological evidence of humoral autoimmune response against retina in Toxoplasma gondii uveitis

AUTOR(ES)

Sylvia Regina Temer Cursino

DATA DE PUBLICAÇÃO

2008

RESUMO

Ocular toxoplasmosis is attributed to the parasite, but autoimmunity could have a role in this process. Human sera, positive of anti-T. gondii IgG, show high levels of anti-retina IgG, measured by several antigens, as compared to T. gondii seronegative samples. Sera from patients with uveitis from other origins also had higher anti-retina abs levels. Challenged and/or immunized hamsters showed low anti-retina abs levels, without antigen mimicry. Toxoplasmic retinochoroiditis presents a humoral anti-retina abs, probably worsening the parasite direct effect. Those antibodies could be used as markers of eye involvement in toxoplasmosis seropositive patients, as a screening for eye examination.

ASSUNTO(S)

modelos animais vacinas atenuadas antibody formation/immunology retina/imunologia uveitis posterior retina/immunology toxoplasma formação de anticorpos/imunologia uveíte posterior arrestina vaccines attenuated toxoplasma models animals arrestin

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