Antigens Cd4
Mostrando 1-12 de 705 artigos, teses e dissertações.
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1. Precursor B-lineage acute lymphoblastic leukemia patients with aberrant natural killer cell and T cell - lineage antigen expression: experience from a tertiary cancer care center
Abstract Introduction Flow cytometric immunophenotyping (FCI) plays a major role in diagnosing hematologic malignancies. In patients diagnosed with precursor B-lineage acute lymphoblastic leukemia (B-ALL), expression of certain non-lineage/cross lineage antigens is of prognostic and cytogenetic relevance. There is a paucity of studies that have comprehensiv
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations
ABSTRACT Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the
Braz J Infect Dis. Publicado em: 2017-12
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3. Role of T. cruzi exposure in the pattern of T cell cytokines among chronically infected HIV and Chagas disease patients
OBJECTIVES: The impact of Chagas disease (CD) in HIV-infected patients is relevant throughout the world. In fact, the characterization of the adaptive immune response in the context of co-infection is important for predicting the need for interventions in areas in which HIV and Chagas disease co-exist. METHODS: We described and compared the frequency of cy
Clinics. Publicado em: 2017-11
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4. Construction of a fusion plasmid containing the PSCA gene and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and its anti-tumor effect in an animal model of prostate cancer
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding, and which has a greater affinity. Fusion of specific antigens to extracellular domain of CTLA4 represents a promising approach to increase the immunogenicity of DNA vaccines. In this study, we evaluated this inter
Braz J Med Biol Res. Publicado em: 24/10/2016
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5. Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection
Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from n
Mem. Inst. Oswaldo Cruz. Publicado em: 2016-02
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6. Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
The effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated. This study quantified and evaluated the function of memory T-cell subsets in response to soluble Leishmania antigens (SLA) from patients coinfected with HIV and Leishmania with tegumentary leishmaniasis (TL). E
Mem. Inst. Oswaldo Cruz. Publicado em: 02/10/2013
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7. Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens
Introduction CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease. Methods Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for l
Rev. Soc. Bras. Med. Trop.. Publicado em: 10/05/2013
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8. InfecÃÃo latente por mycobacterium tuberculosis em portadores de infecÃÃo por HIV/AIDS: anÃlise atravÃs do uso de teste tuberculÃnico e teste de liberaÃÃo de interferon-gama / Latent infection by mycobacterium tuberculosis in patients with HIV / AIDS: analysis through the use of tuberculin test and interferon-gamma release
People living with HIV have an enhanced chance to develop and to die of tuberculosis (TB). Many studies demonstrate that chemoprophylaxis for latent tuberculosis infection (LTBI) reduces the progression to active TB. Indeed, the diagnosis of LTBI is controversial. In Brazil, the only test approved for use is the tuberculin skin test (TST), however, this test
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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9. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
Schistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S. mansoni antigens altered the immune response that was induced by the soluble Leishmania antigen (SLA) from cutaneous leishmaniasis (CL) patients. Cytokines were m
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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10. Effect of aging and oral tolerance on dendritic cell function
Oral tolerance can be induced in some mouse strains by gavage or spontaneous ingestion of dietary antigens. In the present study, we determined the influence of aging and oral tolerance on the secretion of co-stimulatory molecules by dendritic cells (DC), and on the ability of DC to induce proliferation and cytokine secretion by naive T cells from BALB/c and
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
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11. Análise da imunogenicidade de uma vacina de DNA codificando epitopos CD4 promíscuos e conservados do HIV-1 em camundongos BALB/c e transgênicos para moléculas de HLA classe II / Immunogenicity analysis of a DNA vaccine encoding promiscuous and conserved HIV-1 CD4 epitopes in BALB/c and HLA class II transgenic mice
Abordagens atuais no desenho de vacinas contra o HIV-1 estão focadas em imunógenos que codificam proteínas inteiras do HIV-1 e visam induzir respostas citotóxicas específicas. É concebível que vacinas bem-sucedidas devem induzir respostas contra múltiplos epitopos do HIV-1, coincidindo com seqüências das cepas circulantes do vírus, conhecido por s
Publicado em: 2010
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12. Evaluation of the involvement of Toll like and C-type lectin receptors in the immunessuppression induced by high molecular weight components from Ascaris suum extract. / Avaliação da participação dos receptores do tipo Toll e lectinas tipo C na supressão da resposta imune induzida por componentes de alta massa molecular do extrato de Ascaris suum.
Helminths and antigens derived from them are potent immunemodulators. High molecular weight components of Ascaris suum extract (PI) suppress the anti-ovalbumin response. The PI components inhibit in antigen-presenting cells (APCs), as dendritic cells (DCs), the expression of MHC-II and coestimulatory molecules and, thus the CD4 + T cells activation. APCs via
Publicado em: 2010