Evaluation of the involvement of Toll like and C-type lectin receptors in the immunessuppression induced by high molecular weight components from Ascaris suum extract. / Avaliação da participação dos receptores do tipo Toll e lectinas tipo C na supressão da resposta imune induzida por componentes de alta massa molecular do extrato de Ascaris suum.

AUTOR(ES)

Bruna Cristina Favoretto

DATA DE PUBLICAÇÃO

2010

RESUMO

Helminths and antigens derived from them are potent immunemodulators. High molecular weight components of Ascaris suum extract (PI) suppress the anti-ovalbumin response. The PI components inhibit in antigen-presenting cells (APCs), as dendritic cells (DCs), the expression of MHC-II and coestimulatory molecules and, thus the CD4 + T cells activation. APCs via membrane receptors, as the Toll like (TLRs) and C-type lectin (CLRs), recognize distinct pathogens and then promote the effector immune response. Therefore, it was studied the role of TLRs and CLRs expressed on APCs in immunesuppression induced by PI. It was observed that PI inhibited the expression of TLR1, 2, 4 and 9 in the induction phase of adaptive response. The suppressive effect of PI in anti-OVA response and DCs maturation was independent of TLR2 and TLR4, however the CLRs seem to be involved in this process. These data can contribute to clarify the action mechanisms of immunosuppressive molecules.

ASSUNTO(S)

células dendríticas ascaris suum recognition high molecular weight components dendritic cells receptores de antígenos antigen receptors immunossuppression imunossupressão ascaris suum componentes de alta massa molecular reconhecimento

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