Animals Melanoma
Mostrando 1-12 de 51 artigos, teses e dissertações.
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1. Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer
While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of therapies that target multiple aspects of the cancer-immunity cycle. Our own work involves the use of gene transfer technology
Clinics. Publicado em: 06/09/2018
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2. Effects of nivolumab in peritoneal carcinamatosis of malign melanoma in mouse model
Abstract Purpose: To evaluate the efficacy of nivolumab and comparison with dacarbazine (DTIC) on peritoneal carcinomatosis of malignant melanoma in mouse model. Methods: Mouse skin melanoma cells was injected under the capsule of the peritoneal surface in the left side of the abdomen. On postoperative day ten, mouses randomised into three groups. Group 1
Acta Cir. Bras.. Publicado em: 2017-12
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3. Atividade da fosfoetanolamina sintética em melanoma murino experimental / Activity of synthetic phosphoethanolamine in experimental murine melanoma
The low responsiveness of melanoma to traditional treatments together with its increasing incidence makes the development of new therapeutic strategies against this type of cancer extremely important. In this study, we used a murine melanoma model to evaluate the effects of synthetic phosphoethanolamine (PEA) on the development of this tumor. In vitro, PEA h
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/11/2012
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4. Análise metabolômica de animais portadores de melanoma murino B16F10 por espectroscopia de ressonância magnética nuclear (RMN) / Metabolomic analyzes of animals with murine melanoma B16F10 spectroscopy nuclear magnetic resonance (NMR)
O metaboloma é definido como a coleção qualitativa e quantitativa de todos os metabólitos de baixa massa molecular presentes nas células, os quais participam de reações bioquímicas necessárias para a manutenção, crescimento e fisiologia celular. A avaliação metabolômica permite o delineamento do processo bioquímico de sistemas a fim de ampliar
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/11/2012
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5. Estudo da atividade citotóxica do poliacetileno 5-octa-2, 4, 6-triinil-furan-2(5H)-ona / Study of the cytotoxic activity of polyacetylene 5-octa-2,4,6-triinil-furan-2 (5H)-one
Skin cancers are the most common types of cancer in Brazil, and correspond to around 25% of all malignant tumors recorded. Of these, melanoma represents at least 5% and is characterized by its high metastatic power. The development of anticancer agents from natural products is considered critical to pharmacology, and interest in the development of more effec
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/06/2012
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6. Toxicidade seletiva da crotamina do veneno de Crotalus durissus terrificus sobre as células indutoras de tumores. / Cancer Cells selective toxicity of crotamine, Crotalus durissis terrificus.
Crotamina é um peptídeo de baixo peso molecular composto de 42 resíduos de aminoácidos. A presença de nove resíduos de lisina e três pontes dissulfeto confere a crotamina compactibilidade elevada, estabilidade, carga positiva líquida, apresentando similaridade estrutural com defensina, um peptídeo antimicrobiano do epitélio humano. Crotamina até 1
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2011
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7. Estudo dos efeitos da terapia fotodinâmica na progressão tumoral e em modelos celulares tridimensionais / Study of the effects of photodynamic therapy on tumor progression and in three-dimensional cellular models.
Melanoma is the type of skin cancer with poor prognosis due to its high probability of suffering metastases. Currently there are few effective treatments for the this, and the survival of patients with metastases is very low, around 8 months, with cure rates of these conditions do not exceed 1%. Photodynamic therapy (PDT) is a therapeutic modality selective
Publicado em: 2010
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8. Vernonia scorpioides ethyl acetate III subfraction effect evaluation in model of in vivo and in vitro murine melanoma / Avaliação dos efeitos da subfração Acetato de etila III de Vemonia scorpioides em modelo de melanoma murino in vivo e in vitro
Vernonia scorpioides has been tradionally used in Brazil in order to treat skin disorders and chronic wounds, such as leg ulcers in result to diabetes. The present study investigated the ethyl acetate III subfraction effect obtained from fresh leaves of Vernonia scorpioides in vitro, where B16F10 murine melanoma cells were submitted to treatment with several
Publicado em: 2009
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9. Paullinia cupana Mart var. sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice
We showed that guaraná (Paullinia cupana Mart var. sorbilis) had a chemopreventive effect on mouse hepatocarcinogenesis and reduced diethylnitrosamine-induced DNA damage. In the present experiment, we evaluated the effects of guaraná in an experimental metastasis model. Cultured B16/F10 melanoma cells (5 x 10(5) cells/animal) were injected into the tail ve
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-04
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10. Terapia antiangiogênica de tumores utilizando células produtoras de endostatina encapsuladas em dispositivos de imunoisolamento / ANTIANGIOGENIC THERAPY USING ENDOSTATIN PRODUCER CELLS ENCAPSULATED IN IMMUNOISOLATION DEVICES.
Endostatin is a specific inhibitor of endothelial cell proliferation, migration and a potent angiogenesis inhibitor. It has been shown that continuous administration of endostatin is more effective in tumor suppression than the same dose administered s.c. daily. Achieving concentration of endostatin to combat tumor growth is complicated by the short life of
Publicado em: 2008
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11. Estudo radiográfico e por tomografia computadorizada das formações orais em cães / Radiographic and computed tomographic studies of oral tumors in dogs
The oral cancers represent the fourth most common cancer in dogs. Imaging of oral cancer is needed to determine the tumor extension and the affected local tissues, assisting in prognosis and surgical planning. Currently the radiographic examination is the most used diagnostic method. It is accessible and less expensive, but the large number of structures in
Publicado em: 2008
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12. Estudos de citotoxidez e ação antimicrobiana de tiossemicarbazonas derivadas de piridina: efeitos da coordenação a metais
The present work reports an investigation on the effect of metal coordination on the pharmacological profile of two thiosemicarbazone families: 2-pyridinoformamide thiosemicarbazones and N(4)-tolyl thiosemicarbazonas derived from 2-acetylpyridine and 2-benzoylpyridine. Complexes [Cu(H2Am4DH)Cl2] (1) Cu(H2Am4Me)Cl2] (2), [Cu(H2Am4Et)Cl]Cl (3) e [Cu(2Am4Ph)Cl]
Publicado em: 2008