Animals Melanoma
Mostrando 13-24 de 51 artigos, teses e dissertações.
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13. Evidence for a dual role of galectin-3 in murine melanoma growth / Evidência da dualidade funcional de galectina-3 no crescimento de melanoma murino
Tumors have been described as microenvironments composed not only by malignant cells, but also by endothelial cells, fibroblasts and leukocytes, which can promote tumor growth and angiogenesis. Galectin-3, a b-galactoside binding protein, is expressed by monocytes/macrophages and others leukocytes. In fact, several lines of evidence suggest that galectin-3 a
Publicado em: 2007
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14. Neuroimunes aspects of mice kept in a stable social relation / Aspectos neuroimunes de camundongos mantidos em uma relação social estável
The objective of the present work was to investigate the repercussions of a stable social relationship on different parameters of the behavior, neurochemical and immune activity of dominant and submissives mice. Adult males (with approximately 90 days of age) kept in pairs since wean it, had been determined as dominant or submissives, after three consecutive
Publicado em: 2006
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15. Neoplasias melanocíticas cutâneas em cães: aspectos clínicos e histopatológicos em 58 casos / Cutaneous melanocytic neoplasms in dogs: aspects clinics and histopathologics in 58 cases
Thirty nine cases (42 lesions) of melanocytoma and nineteen cases (19 lesions) of canine cutaneous melanoma were analyzed clinic and histopathologically. The melanocytomas affected the young animals as well as the old ones, without a sexual predisposition. The most affected dogs were the ones of the Schnauzer and Doberman breed, being followed by those witho
Publicado em: 2005
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16. Monoclonal antibodies inhibit the adhesion of mouse B 16 melanoma cells in vitro and block lung metastasis in vivo.
Seven monoclonal antibodies against mouse B 16 melanoma cells (produced in syngeneic C57BL/6 mice) were selected that blocked the adhesion of melanoma cells to tissue culture dishes. These antibodies were found to be directed against antigens on the surface of mouse B 16 melanoma cells but not on normal mouse cells such as 3T3 fibroblasts. Similarly, the ant
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17. Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes.
Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequestration of P. falciparum in the squirrel m
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18. A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish–swordtail hybrids
The genetic basis of spontaneous melanoma formation in spotted dorsal (Sd) Xiphophorus platyfish–swordtail hybrids has been studied for decades, and is adequately explained by a two-gene inheritance model involving a sex-linked oncogene, Xmrk, and an autosomal tumor suppressor, DIFF. The Xmrk oncogene encodes a receptor tyrosine kinase related to EGF
The National Academy of Sciences of the USA.
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19. Inhibition of melanogenesis in B16-F1 melanoma cells after exposure to diflubenzuron.
The insect growth regulator diflubenzuron was found to be a potent inhibitor of melanosome synthesis and release in mouse melanoma cell cultures, and after three to five successive passages of melanoma cells in growth medium containing this compound, these cells were unable to produce monolayers in untreated medium and were incapable of inducing tumor format
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20. Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis.
Monoclonal antibody MB3.6 (IgG3) recognizes disialoganglioside GD3, which represents a major surface marker on most human melanoma cells. We demonstrate that this antibody effectively lyses four human melanoma cell lines expressing significant levels of GD3 on their surface by either of two mechanisms: antibody-dependent cellular cytotoxicity (ADCC) or compl
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21. In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma.
In vivo transfection of established tumors with immunostimulatory genes can elicit antitumor immunity. Therefore, we evaluated the safety and efficacy of intratumoral injections of a bacterial superantigen with a cytokine gene in dogs with malignant melanoma, a spontaneous and highly malignant canine tumor. 26 dogs with melanoma were treated with lipid-compl
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22. Wavelengths effective in induction of malignant melanoma.
It is generally agreed that sunlight exposure is one of the etiologic agents in malignant melanoma of fair-skinned individuals. However, the wavelengths responsible for tumorigenesis are not known, although DNA is assumed to be the target because individuals defective in the repair of UV damage to DNA are several thousandfold more prone to the disease than t
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23. Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin
Clinical and experimental evidence suggests that spreading of malignant cells from a localized tumor (metastasis) is directly related to the number of microvessels in the primary tumor. This tumor angiogenesis is thought to be mediated by tumor-cell-derived growth factors. However, most tumor cells express a multitude of candidate angiogenesis factors a
The National Academy of Sciences of the USA.
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24. Murine monoclonal anti-idiotope antibody breaks unresponsiveness and induces a specific antibody response to human melanoma-associated proteoglycan antigen in cynomolgus monkeys.
The mouse monoclonal antibody MEM136 (mAb1) is directed against an epitope on human melanoma-associated proteoglycan antigen (MPG). This epitope is also present on various normal human and subhuman tissues. A monoclonal murine anti-idiotope (anti-Id) antibody (mAb2), designated I-Mel-2, was generated against MEM136 and used as a surrogate antigen for the MPG