Ames Test
Mostrando 13-24 de 59 artigos, teses e dissertações.
-
13. Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone
Currently, a wide range of research involving natural products is focused on the discovery of new drugs in many different therapeutic areas. A great number of the synthetic compounds on the market were derived from natural products, especially plants. Nemorosone is the major constituent of the floral resin of Clusia rosea Jacq., Clusiaceae, and in Cuban prop
Revista Brasileira de Farmacognosia. Publicado em: 26/08/2011
-
14. Antitumoral, mutagenic and (anti)estrogenic activities of tingenone and pristimerin
Cancer constitutes the second main mortality cause in the world, after cardiovascular diseases. In spite of the progresses in the chemotherapeutics treatments, many patients fail chemotherapy, mainly because of side effects or multi-drugs resistance, proving the need and importance of the research for new molecules with anticancer activity, more effective an
Revista Brasileira de Farmacognosia. Publicado em: 26/08/2011
-
15. Mutagenicity induced by the hydroalcoholic extract of the medicinal plant Plathymenia reticulata Benth
Plathymenia reticulata Benth has an anti-inflammatory effect and is capable of neutralizing the neuromuscular blockade induced by Bothrops jararacussu or Crotalus durissus terrificus venoms, probably by precipitating venom proteins (an effect caused by plant tannins). The present study aimed to evaluate the mutagenic activity of P. reticulata by using the Sa
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
-
16. Participação de enzimas de reparo por excisão de bases na restauração de lesões induzidas pela associação da radiação ultravioleta A e cloreto estanoso em Escherichia coli / Involvement of base excision repair enzymes in restoring ultraviolet A and stannous chloride induced lesions in Escherichia coli
Stannous chloride (SnCl2) and ultraviolet radiation A (UVA) are able to induce lesions in different cellular structures, including DNA, manly through ROS generation. The aim of this work was to study the mutagenesis and repair of lesions induced by the association of UVA (pre treatment) with SnCl2. It was evaluated the action of base excision repair (BER) en
Publicado em: 2010
-
17. The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata
Pueraria mirifica is a Thai phytoestrogen-rich herb traditionally used for the treatment of menopausal symptoms. Pueraria lobata is also a phytoestrogen-rich herb traditionally used in Japan, Korea and China for the treatment of hypertension and alcoholism. We evaluated the mutagenic and antimutagenic activity of the two plant extracts using the Ames test pr
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-09
-
18. Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium
Nitrite, which is present in preserved meat and can be produced in the oral cavity by reduction of nitrate taken from vegetables, could react in stomach with nitrosatable drugs, giving genotoxic-carcinogenic N-nitroso compounds (NOC). The mutagenicity of reaction mixtures formed by sodium nitrite and selected sulfa-drugs (sulfathiazole, HST; phtalylsulfathia
Química Nova. Publicado em: 2009
-
19. âQuem acreditou no amor, no sorriso, na florâ: a confianÃa nas relaÃÃes amorosas
Lâobjectif du prÃsent travail est de prÃsenter une discussion sur le concept de confiance dans les rapports amoureux, qui pourra Ãtre utile aux nouvelles inquiÃtudes et interrogations sur les relations affectives dans la contemporanÃitÃ, en tenant compte des nouveaux modÃles de rapports adoptÃs. Pour cela, nous sommes partis dâauteurs qui ont contr
Publicado em: 2009
-
20. Avaliação da genotoxicidade das águas do lençol freático sob a Universidade Federal do Rio Grande do Norte
The groundwater represents the most important freshwater supply of planet. Dailly, in all world a great amount of toxic and genotoxic material reaches the aquatic systems, mainly the aquifers. The Barreiras aquifer through of five water wells is responsible for the supplying of Universidade Federal do Rio Grande do Norte (UFRN). All water wells are polluted
Publicado em: 2007
-
21. Investigação de dioxinas, furanos, hidrocarbonetos policíclicos aromáticos no material particulado e gases emitidos por motores diesel / Investigation of dioxins, furans and polycyclic aromatic hydrocarbons in particulate material and gases emitted by diesel engines.
To investigate emission of chlorinated dioxins and furans (PCDD/Fs) and polycyclic aromatic hydrocarbons (PAHs) in heavy duty diesel engines, through the analysis of particulate material and gases in the exhaust.To verify mutagenicity of collected particulate material and gasesous sample extracts. Material and Methods: The engine emissions tests were done in
Publicado em: 2007
-
22. Avaliação da genotoxicidade das águas sueprficiais da Barragem Engenheiro Armando Ribeiro Gonçalves, Assu/RN
A contaminação de reservatórios de água é um dos principais problemas da atualidade. A Barragem Engenheiro Armando Ribeiro Gonçalves (EARG), (0608S; 3707W) localizada no estado do Rio Grande do Norte, é a segunda maior barragem do nordeste brasileiro, responsável pelo abastecimento doméstico de aproximadamente 415 mil habitantes do semi-árido brasi
Publicado em: 2007
-
23. Análise da presença de agentes mutagênicos nas águas do Rio Pitimbú/RN
The Pitimbu River is located at the oriental portion of the State of Rio Grande do Norte, including three importants cities named Macaíba, Parnamirim e Natal. Although its high importance as a water source, which supplys great part of the South Zone of the Natal city, this river receives a large quantity of domestic and industrial waste water without treatm
Publicado em: 2006
-
24. Evaluation of the mutagenic potential and in vitro metabolization of three anti-inflammatory parsalmide analogues / Avaliação do potencial mutagenico e metabolização in vitro de tres analogos do antiinflamatorio parsalmide
In this study, the mutagenicity of the anti-inflammatory parsaJmide [5-amino-N-butyl-2-(2-propynyloxy)-benzamide] analogues PA7 [5-anuno-N-butyl-2-cyclohexyloxy-benzamide], PA10 [5-amino-N-butyl-2-phenoxy-benzamide] and PA31 [5-arnino-N-butyl-2-(p-tolyloxy)-benzamide] was determined by an Ames Salmonella assay. The experiments were performed by preincubating
Publicado em: 2006