Airway Smooth Muscle
Mostrando 1-12 de 130 artigos, teses e dissertações.
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1. Proposição de um modelo matemático para o estudo da alteração mecânica do músculo liso da traquéia de ratos Wistar exposto à solução de formaldeído e submetido a doses crescentes de um agente contrátil / Proposition of a mathematical model to study the mechanical change of the smooth muscle of the trachea of Wistar rats exposed to formaldehyde solution and subjected to increasing doses of a contractile agent
The viscoelastic properties of the mammalian lung is mainly determined by the mechanical properties, structure and regulation of the airways smooth muscle. The exposure to polluted air may deteriorate these properties with harmful consequences to individual health. Formaldehyde is an important indoor pollutant that permeate through the smooth muscle tissue f
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/07/2012
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2. EFEITO DO 1,8 CINEOL NOS PARÂMETROS DE CONTRATILIDADE DO MÚSCULO LISO TRAQUEAL E DE MECÂNICA DO SISTEMA RESPIRATÓRIO DE RATOS EXPOSTOS A FUMAÇA DO CIGARRO / EFFECT OF THE PARAMETERS 1.8 cineole muscle contractility TRACHEAL SMOOTH AND MECHANICS OF RESPIRATORY SYSTEM OF RATS EXPOSED TO CIGARETTE SMOKE OF
O 1,8-cineol é um oxido monoterpenico, antinflamatório e miorelaxante nas vias aéreas e já mostrou atividade em diversos tipos de tecidos excitáveis incluindo diversos tipos de músculo liso. Sabe-se hoje que a fumaça do cigarro é um poluente capaz de provocar doenças principalmente no trato respiratório podendo alterar o mecanismo contrátil do mú
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/03/2012
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3. Participação dos canais de potássio no efeito relaxante do ácido ent-7a-hidroxitraquiloban-18-oico em traqueia isolada de cobaia / Participation of potassium channels in the ent-7a-hidroxitrachyloban-18-oic acid relaxation effect on guinea pig trachea
From Xylopia langsdorfiana A. St-Hil. &Tul. stem bark was isolated the diterpene of trachylobane class, ent-7α-hydroxytrachyloban-18-oic acid (trachylobane-318) that in previous studies showed to be able to relax guinea-pig trachea pre-contracted by carbachol (CCh). Thus, we aimed to investigate the action mechanism underlying in this trachylobane-318 r
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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4. Dimensões das vias aéreas na asma fatal e na doença pulmonar obstrutiva grave / Airway dimensions in fatal asthma and severe COPD
Background: In some patients with chronic asthma, clinical and physiological similarities with chronic obstructive pulmonary disease may co-exist, such as partial reversibility to bronchodilators despite persistent expiratory airflow obstruction. However, pathologic analyses comparing both diseases in patients of similar age and disease severity are scarce.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/09/2011
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5. Estudo do efeito relaxante de um novo composto doador de óxido nítrico em preparações de traquéias isoladas de ratos / Study of the relaxing effect of a new nitric oxide donor compound in preparations of isolated rat tracheae
This study evaluated the mechanisms of relaxation of two nitric oxide (NO) donors, ruthenium complex [Ru(terpy)(bdq)NO+]3+ (Terpy) and sodium nitroprusside (SNP) in isolated trachea of rats. The isolated trachea was sectioned into rings and contracted with carbachol in an organ chamber. The relaxing effect of Terpy and SNP was evaluated at increasing concent
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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6. Inibição da contratilidade do músculo liso traqueal de ratos por um diterpeno caurano isolado de Croton argyrophylloides / Inhibition of tracheal smooth muscle contractility of rats by a diterpene isolated from Croton caurano argyrophylloides
Diversos diterpenos cauranos isolados de extratos de plantas têm mostrado ação antiespasmódica em diferentes músculos lisos. Nesse estudo, avaliamos os efeitos do rel-(1S, 4aS, 7S, 8aS)-7-(1-vinil)-tetradecahidro-1,4a-dimetilfenantreno-7,8a carbolactona-1-carboxílico (ATCC), um novo diterpeno caurano recentemente isolado de Croton argyrophylloides, em
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/12/2009
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7. Componentes da matriz extracelular e seus reguladores no músculo liso brônquico na asma / Extracellular matrix components and regulators in the airway smooth muscle in asthma
There is an intimate relationship between the extracellular matrix (ECM) and smooth muscle cells within the airways. Few studies have comprehensively assessed the composition of different ECM components and its regulators within the airway smooth muscle (ASM) in asthma. With the aid of image analysis, the fractional area of total collagen and elastic fibres
Publicado em: 2009
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8. Asthma: where is it going?
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness and inflammation are still debated. The first mechanism identified as important for asthma was bronchial hy
Brazilian Journal of Medical and Biological Research. Publicado em: 20/08/2008
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9. Caracterização das fases imediata e tardia da resposta inflamatória de tecido pulmonar periférico de cobaias sensibilizadas / Comparison of early and late responses to antigen of sensitized guinea pigs parenchymal lung strips
The peripheral lung parenchyma has been studied as a component of the asthmatic inflammatory response. During induced constriction, tissue resistance increases in different asthma models. Approximately 60% of the asthmatic patients show early and late responses. The late response is characterized by more severe airway obstruction. In the present study, we ev
Publicado em: 2006
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10. ESTUDO DOS EFEITOS DA MELATONINA SOBRE A FUNÃÃO PULMONAR E A QUALIDADE DO SONO NA ASMA / Study of effects of Melatonin on pulmonary function and quality of sleep in asthma
Disturbed sleep is common in asthma and impairs quality of life in these patients. Melatonin has sleep-inducing activity and reportedly affects smooth muscle tone and inflammation. The aim of this study was to evaluate the effect of melatonin on sleep in female patients with stable mild and moderate asthma. Twenty consecutive patients were recruited into the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/07/2004
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11. Participação dos canais de cálcio na hiperreatividade induzida por ovalbumina em traquéias isoladas de ratos / Role of the calcium channels on ovalbumin-induced rat airway hyperresponsiveness
In order to verify the interference of the antigenic challenge on traqueal contractility in vitro, male rats (250 -350 g) were ovalbumine (OVA)-sensitized and, 13 to 14 days later, they were challenged through the sensitizing antigen inhalation (OVA, 1 mg/ml, followed by 5 mg/ml). Animals were sacrificed immediately (SD0) or 24 hours (SD24) after the antigen
Publicado em: 2004
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12. Estudo farmacologico do óleo essencial do Croton nepetaefolius Baill sobre os musculos lisos traqueal e vascular e sobre as propriedades eletrofisiologicas de neuronios fasicos de ganglio celiaco / Pharmacological study of the essential oil of Croton nepetaefolius on both vascular and tracheal smooth muscle and on electrophysiological properties of celiac ganglion phasic neurones
Croton nepetaefolius is an aromatic bush found in brazilian Northeast region, called marmeleiro sabiá, and it is used in folk medicine as an antispasmodic and carminative agent. Its essential oil is comprised of 1,8-cineole, methyl-eugenol, xanthoxylin, terpineol and others constituents. Recent studies showed some pharmacological activities of the essential
Publicado em: 2002