Adrenoceptors
Mostrando 1-12 de 147 artigos, teses e dissertações.
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1. Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion
Abstract Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion of left anterior descendent coronary artery (10 min) and reper
Acta Cir. Bras.. Publicado em: 03/06/2019
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2. Erratum for: “Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II” [Braz J Med Biol Res (2018) 51(12): e7526]
Braz J Med Biol Res. Publicado em: 10/01/2019
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3. Effects of dipyrone on the digestive tract
Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-se
Braz J Med Biol Res. Publicado em: 10/01/2019
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4. Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II
It has been previously demonstrated that the hemodynamic effect induced by angiotensin II (AII) in the liver was completely abolished by losartan while glucose release was partially affected by losartan. Angiotensin II type 1 (AT1) and adrenergic (∝1- and β-) receptors (AR) belong to the G-proteins superfamily, which signaling promote glycogen breakdown a
Braz J Med Biol Res. Publicado em: 14/11/2018
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5. ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia
This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound co
Braz J Med Biol Res. Publicado em: 24/11/2016
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6. Effect of selective β-adrenoceptor blockade and surgical resection of the celiac-superior mesenteric ganglion complex on delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats
There is evidence for participation of peripheral β-adrenoceptors in delayed liquid gastric emptying (GE) induced in rats by dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At). The present study aimed to determine whether β-adrenoceptors are involved in delayed GE induced by phenylpyrazole derivatives and the role of the prevertebral sympathetic ne
Braz J Med Biol Res. Publicado em: 02/02/2016
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7. Role of α2-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis
Central α2-adrenoceptors and the pontine lateral parabrachial nucleus (LPBN) are involved in the control of sodium and water intake. Bilateral injections of moxonidine (α2-adrenergic/imidazoline receptor agonist) or noradrenaline into the LPBN strongly increases 0.3 M NaCl intake induced by a combined treatment of furosemide plus captopril. Injection of mo
Braz J Med Biol Res. Publicado em: 10/01/2014
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8. Evidence for the involvement of peripheral β-adrenoceptors in delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats
Dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At) delay liquid gastric emptying (GE) in rats. We evaluated adrenergic participation in this phenomenon in a study in male Wistar rats (250-300 g) pretreated subcutaneously with guanethidine (GUA), 100 mg·kg−1·day−1, or vehicle (V) for 2 days before experimental treatments. Other groups of animals
Braz J Med Biol Res. Publicado em: 27/09/2013
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9. Papel dos receptores beta 2-adrenérgicos nas alterações musculoesqueléticas desencadeadas pela insuficiência cardíaca. / Role of beta2-adrenergic receptors on skeletal muscle alterations induced by heart failure
A insuficiência cardíaca (IC) é uma síndrome complexa que envolve múltiplos sistemas e mecanismos compensatórios neuro-hormonais, acompanhada de altos índices de morbidade e mortalidade, e caracterizada por sintomas clínicos como fadiga, dispneia, e intolerância aos esforços físicos. Embora a IC seja uma síndrome de origem cardíaca, observam-se
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2012
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10. Polimorfismo dos receptores Beta 3 adrenérgicos e sua correlação com a síndrome de bexiga hiperativa. / Beta 3 adrenoceptors and its overactive bladder syndrome correlation.
Objetivo: avaliar se o polimorfismo no códon 64 do gen do receptor 3 adrenérgico com a troca de um Triptofano pela Arginina constitui-se em fator de risco para a Síndrome de Bexiga Hiperativa. Casuística e Métodos: estudo caso controle envolvendo 218 pacientes pertencentes ao Ambulatório de Climatério e Ambulatório de Bexiga Hiperativa. O grupo caso
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/05/2011
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11. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors
The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium handling (Na+/K+-ATPase and Ca2+-ATPases) and growth (ERK1/2, JNK1/2 and p38) in mice with cardiac-selective overexpression of constitutivel
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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12. Estudo do dimorfismo sexual na participação de adrenoceptores beta na nocicepção induzida por formalina na ATM de ratos / Sex differences in the antinociception mediated by blockade of beta adrenoceptors in the rat temporomandibular joint
Temporomandibular disorders (TMD) are pain conditions that affect the temporomandibular joint (TMJ) and masticatory muscles. These conditions present higher prevalence, severity and duration in females and appear to be associated with inflammation. Although non-steroidal anti-inflammatory drugs have been frequently used in the control of inflammatory pains,
Publicado em: 2010