Estudo do dimorfismo sexual na participação de adrenoceptores beta na nocicepção induzida por formalina na ATM de ratos / Sex differences in the antinociception mediated by blockade of beta adrenoceptors in the rat temporomandibular joint

AUTOR(ES)

Nadia Cristina Favaro-Moreira

DATA DE PUBLICAÇÃO

2010

RESUMO

Temporomandibular disorders (TMD) are pain conditions that affect the temporomandibular joint (TMJ) and masticatory muscles. These conditions present higher prevalence, severity and duration in females and appear to be associated with inflammation. Although non-steroidal anti-inflammatory drugs have been frequently used in the control of inflammatory pains, many patients may be intolerant to the prolonged treatment and some of them may not respond to the effect of these medications. It is already known that inflammatory pain has a sympathetic component that may predominate in the cases less sensitive to the non-steroidal anti-inflammatory drugs. Therefore, in this study we investigated the contribution of this sympathetic component in TMJ´ pain. Specifically we investigated (1) the participation of ß1, ß2 and ß3 adrenoceptors in the rat´s TMJ nociception induced by formalin and (2) the existence of sexual dimorphism in the effect of ß-blockers in the TMJ nociception. Co-administration of formalin with ß1, ß2 and ß3 adrenoceptors antagonists, Atenolol, ICI 118.551 and SR59230A respectively, significantly reduced formalin-induced TMJ nociception. Co-administration of a low dose of ß1 (6µg) or ß2 (0,1µg) adrenoceptors antagonists with formalin significantly reduced formalin-induced TMJ nociception in females but not in males, indicating the existence of a sexual dimorphism in the effect of these antagonists. The findings of this study indicate that beta adrenoceptors, specifically ß1, ß2 and ß3 adrenoceptors significantly reduce TMJ pain. Furthermore, females are more sensitive than males to the antinociceptive effect of ß1 and ß2 adrenoceptor antagonists

ASSUNTO(S)

articulação temporomandibular temporomandibular joint

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