Adrenergic Receptors
Mostrando 1-12 de 585 artigos, teses e dissertações.
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1. Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion
Abstract Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion of left anterior descendent coronary artery (10 min) and reper
Acta Cir. Bras.. Publicado em: 03/06/2019
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2. Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats
Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of hemorrhage/resuscitation (HS) and subsequent endotoxemia. E
Braz J Med Biol Res. Publicado em: 25/02/2019
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3. Antidiarrheal effect of extract from the bark of Combretum leprosum in mice
Abstract This study investigated the effects of the ethanolic extract from the bark of Combretum leprosum (ECL) on intestinal transit and castor-oil induced diarrhea in mice. The oral administration of ECL (750 and 1000 mg/kg) slowed intestinal transit (ID50 of 455 mg/kg). The ECL (250-1000 mg/kg) reduced castor-oil induced diarrhea, in a time- and dose-depe
An. Acad. Bras. Ciênc.. Publicado em: 17/12/2018
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4. Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II
It has been previously demonstrated that the hemodynamic effect induced by angiotensin II (AII) in the liver was completely abolished by losartan while glucose release was partially affected by losartan. Angiotensin II type 1 (AT1) and adrenergic (∝1- and β-) receptors (AR) belong to the G-proteins superfamily, which signaling promote glycogen breakdown a
Braz J Med Biol Res. Publicado em: 14/11/2018
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5. Adrenergic receptor β3 is involved in the memory consolidation process in mice
Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends o
Braz J Med Biol Res. Publicado em: 06/08/2018
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6. Dipyrone in association with atropine inhibits the effect on gastric emptying induced by hypoglycemia in rats
Atropine (AT) and dipyrone (Dp) induce a delay of gastric emptying (GE) of liquids in rats by inhibiting muscarinic receptors and activating β2-adrenergic receptors, respectively. The objective of the present study was to determine the effects of pretreatment with AT and Dp, given alone or in combination, on the effect of hypoglycemia in the liquid GE in ra
Braz J Med Biol Res. Publicado em: 31/08/2017
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7. Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves
ABSTRACT Muntingia calabura L., Muntingiaceae, is a medicinal plant for various pain-related diseases. The aims of the present study were to determine the antinociceptive profile and to elucidate the possible mechanisms of antinociception of petroleum ether partition obtained from crude methanol extract of M. calabura leaves using various animal models. The
Rev. bras. farmacogn.. Publicado em: 2016-08
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8. Modulatory effects of taurine on jejunal contractility
Taurine (2-aminoethanesulfonic acid) is widely distributed in animal tissues and has diverse pharmacological effects. However, the role of taurine in modulating smooth muscle contractility is still controversial. We propose that taurine (5-80 mM) can exert bidirectional modulation on the contractility of isolated rat jejunal segments. Different low and high
Braz J Med Biol Res. Publicado em: 14/10/2014
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9. Alpha adrenergic receptors in renal pelvis and calyces: can rat models be used?
We aimed, in this study, to determine the distribution of α-1 AR subtypes in rat and human pelvis and calyces, and to evaluate, by comparing these two species, the possibility of rats to be used as models for humans. Twenty patients with renal carcinoma were included into the study. The patients underwent radical nephrectomy for renal cell carcinoma (RCC).
Int. braz j urol.. Publicado em: 2014-10
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10. Effects of different frequencies of transcutaneous electrical nerve stimulation on venous vascular reactivity
Transcutaneous electrical nerve stimulation (TENS) is a type of therapy used primarily for analgesia, but also presents changes in the cardiovascular system responses; its effects are dependent upon application parameters. Alterations to the cardiovascular system suggest that TENS may modify venous vascular response. The objective of this study was to evalua
Braz J Med Biol Res. Publicado em: 2014-05
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11. Vasoconstrictor effect of Africanized honeybee (Apis mellifera L.) venom on rat aorta
Background : Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. mellifera venom (AmV) affects mainly the cardiovascular system, and several works have described its actions on heart muscle. Nevertheless, no work on the pharmacological
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 25/09/2013
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12. Neural mechanisms involved in the delay of gastric emptying of liquids in rats induced by myocardial infarction recent / Mecanismos neurais envolvidos no retardo do esvaziamento gástrico de íiquidos em ratos induzido através do infarto recente do miocardio
O esvaziamento gástrico (EG) consiste na transferência ordenada do conteúdo do estômago para o duodeno, Situações patológicas como alterações hemodinâmicas modificam a velocidade do E.G. e função motora do trato gastrointestinal. O infarto do miocárdio determina retarde do E.G. em ratos, possivelmente pelo estresse causado pela ligadura da arté
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/05/2012