Adducts
Mostrando 1-12 de 654 artigos, teses e dissertações.
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1. Morita-Baylis-Hillman Reaction with 7-Chloroquinoline Derivatives-New Compounds with Potential Anticancer Activity
Morita-Baylis-Hillman adducts (MBHA) is a class of polyfunctional molecules that has been standing out due to their versatility and expressive biological activities. Therefore, this paper describes the synthesis and antiproliferative activity of some new MBHA/7-choroquinoline hybrids. The Michael acceptors were obtained starting from 4,7-dichloroquinoline wh
J. Braz. Chem. Soc.. Publicado em: 2021-02
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2. DNA Damage by Endogenous and Exogenous Aldehydes
The present overview describes the formation of deoxyribonucleic acid (DNA) adducts from endogenous and exogenous aldehydes, such as acetaldehyde, acrolein, crotonaldehyde, malonaldehyde, 4-hydroxy-2-nonenal and 2,4-decadienal. Malonaldehyde reacts with 2’-deoxyguanosine, 2’-deoxyadenosine, and 2’-deoxycytidine, yielding cyclic pyrimidopurinone and acy
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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3. Carbonyl compounds in wine: factors related to presence and toxic effects
RESUMO: O objetivo deste estudo foi revisar os fatores tecnológicos e toxicológicos relacionados à presença de compostos carbonílicos encontrados em vinhos, incluindo acetaldeído, formaldeído, acroleína, carbamato de etila (CE) e furfural. O acetaldeído e o formaldeído podem ser formados através da oxidação do etanol e do metanol, respectivament
Cienc. Rural. Publicado em: 29/07/2019
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4. Fast Triacylglycerol Screening and Semi-Quantitative Analysis of Fatty Acids in Commercial Oils by DIMS with 18-Crown-6 Ether/Trifluoracetic Acid Dopants
Vegetable oil analyses, especially due to the complexity of the oil components, are commonly laborious, requiring several analytical techniques. In this work, electrospray ionization mass spectrometry with direct injection (DIMS), along with 18-crown-6 ether (crown ether) chelating agent and trifluoroacetic acid (TFA), was used to characterize and semi-quant
J. Braz. Chem. Soc.. Publicado em: 2019-02
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5. A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS
ABSTRACT A simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of cabozantinib (CZ) in human plasma using cabozantinib-d4 (CZD4) as an internal standard (IS). Chromatographic separation was performed on Xbridge C18, 50 x 4.6 mm, 5 mm column with an isocratic mobile phase compose
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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6. Determination of Enantioselectivities by Means of Chiral Stationary Phase HPLC in Order to Identify Effective Proline-Derived Organocatalysts
The pyrrolidine fragment is a privileged scaffold within chiral ligands employed in coordination complexes exhibiting catalytic activity in asymmetric reactions and, more recently, as enantioselective organocatalysts per se. Likewise, the employment of (S)-proline as starting material constitutes the most direct form to synthesize those chiral derivatives. A
J. Braz. Chem. Soc.. Publicado em: 2018-05
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7. Study of Reactions of Two Mannich Bases Derived of 4'-Hydroxychalcones with Glutathione by RP-TLC, RP-HPLC and RP-HPLC-ESI-MS Analysis
4'-Hydroxychalcones have been reported to possess several beneficial biological effects. Several lines of evidence accumulated to demonstrate increased biological activities of the Mannich base derivatives of the parent 4'-hydroxychalcones. Bioactivities of chalcones and related α,β-unsaturated ketones are frequently associated with their reactivity with c
J. Braz. Chem. Soc.. Publicado em: 2017-06
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8. A DETERMINAÇÃO DOS PRODUTOS AVANÇADOS DE GLICAÇÃO (AGES) E DE LIPOXIDAÇÃO (ALES) EM ALIMENTOS E EM SISTEMAS BIOLÓGICOS: AVANÇOS, DESAFIOS E PERSPECTIVAS
Advanced glycation (AGEs) and lipoxidation (ALEs) products are formed through specific condensation reactions between nucleophiles (amino groups of free amino acids or their residues in peptides, aminophospholipids or proteins) and electrophiles (carbonyls of reducing sugars, oxidized lipids or others) generating well-defined sets of covalent adducts. The ε
Quím. Nova. Publicado em: 2016-06
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9. Synthesis and Characterization of New Diazenecarboxamide Ligands Using a Selective Adduct Formation with B(C6F5)3
The synthesis and structure of new N-(2,6-diisopropylphenyl)-2-phenyldiazenecarboxamide (L2) and N-(2,6-diisopropylphenyl)-2 (perfluorophenyl) diazenecarboxamide (L3) ligands are described. The subsequent reactions of ligands L1, L2 and L3 with trispentafluorophenylboron gave rise to new adducts (A1), (A2) and (A3), where B(C6F5)3 is coordinated to the carbo
J. Braz. Chem. Soc.. Publicado em: 2016-01
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10. "Photo" Chemistry Without Light?
In the early seventies, Giuseppe Cilento (São Paulo University), Emil White (Johns Hopkins University) and Angelo Lamola (AT&T Bell Laboratories) postulated that typical photochemical reactions could occur in dark parts of living organisms if coupled to enzymatic sources of electronically excited products. Their paradoxical hypothesis of "photochemistry wit
J. Braz. Chem. Soc.. Publicado em: 2015-12
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11. Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which w
Braz. J. Microbiol.. Publicado em: 2014-09
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12. A Importância da determinação analítica de intermediários reativos e de seus produtos de reações com biomacromoléculas: uma mini revisão
Metabolic reactive intermediates can react with biomolecules such as DNA and proteins to produce adducts. Recently, research has shown that such adducts can act as precursors of some chronic diseases (cancer, Parkinson's, immunologic system diseases, etc.), and their determination is important because they are biomarkers of undesirable health effects. These
Quím. Nova. Publicado em: 2014-04