Aberrant Crypt Foci
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane
Abstract Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups re
Acta Cir. Bras.. Publicado em: 28/02/2019
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2. Synbiotic preparation with Lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
Abstract Host microbiome and metabolome are associated with the incidence of colorectal cancer (CC), one of the major health problems in developed countries. The pro and prebiotic supplementation helps to improve the host health. Inulin is one such prebiotic used for the enhancement of naïve probiotic bacterial population. This paper explains the impact of
Food Sci. Technol. Publicado em: 29/05/2017
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3. Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine
ABSTRACT PURPOSE: To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS: Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib a
Acta Cir. Bras.. Publicado em: 2016-12
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4. Extract of the Bark of Bathysa cuspidataAttenuates the Development of Chemically-Induced Preneoplastic Colorectal Lesions in Rats
ABSTRACTThe aim of this study was to investigate the effect of the bark extractBathysa cuspidata on chemically induced preneoplastic colorectal lesions in Wistar rats. Forty male rats were randomly divided into four groups (n = 10 each): saline (control group, oral administration of saline solution 0.9%); dimethylsulfoxide (DMSO, vehicle control), B200 (trea
Braz. arch. biol. technol.. Publicado em: 2015-10
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5. Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice
PURPOSE: To investigate the hemopreventive effect of defatted flaxseed meal in C57BL/6 mice after induction of precancerous colon lesions with 1.2-dimethylhydrazine (DMH). METHODS: Thirty-six 12-week-old C57BL/6 mice were divided into three treatment groups(n=12 in each group): (1) diet with 10% defatted flaxseed meal; (2) diet with defatted flaxseed meal an
Acta Cir. Bras.. Publicado em: 2013-08
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6. Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon
PURPOSE: To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS: The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacter
Acta Cir. Bras.. Publicado em: 2013-05
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7. Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis
β-ionone (βI), a cyclic isoprenoid, and geraniol (GO), an acyclic monoterpene, represent a promising class of dietary chemopreventive agents against cancer, whose combination could result in synergistic anticarcinogenic effects. The chemopreventive activities of βI and GO were evaluated individually or in combination during colon carcinogenesis induced by
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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8. Efeito da fibra como alimento funcional na prevenção da incidência de focos de criptas aberrantes (FCA) no cólon de camundongos induzida por 1,2- dimetilhidrazina / Effect of fiber as a functional food in preventing the incidence of aberrant crypt foci (ACF) in colon of mice induced by 1,2-dimethylhydrazine
The use of healthy diets has been a great ally in the prevention and treatment of various diseases, including colorectal cancer (CRC), a disease that affects much of the world population, configuring it as a public health problem. Genetic and environmental factors are cited as the main causes of the CRC. Among the diet can highlight the environmental. The us
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2010
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9. Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1,2-dimethylhydrazine-induced colon cancer in rats
We determined the effect of fish oil (FO) ingestion on colonic carcinogenesis in rats. Male Wistar rats received 4 subcutaneous injections (40 mg/kg body weight each) of 1,2-dimethylhydrazine (DMH) at 3-day intervals and were fed a diet containing 18% by weight FO (N = 10) or soybean oil (SO, N = 10) for 36 weeks. At sacrifice, the colon was removed, aberran
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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10. Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer
We determined the effect of long-term aerobic swimming training regimens of different intensities on colonic carcinogenesis in rats. Male Wistar rats (11 weeks old) were given 4 subcutaneous injections (40 mg/kg body weight each) of 1,2-dimethyl-hydrazine (DMH, dissolved in 0.9% NaCl containing 1.5% EDTA, pH 6.5), at 3-day intervals and divided into three ex
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-11
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11. Intrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogen
Denervation of the colon is protective against the colon cancer; however, the mechanisms involved are unknown. We tested the hypothesis that the denervated colonic mucosa could be less responsive to the action of the chemical carcinogen dimethylhydrazine (DMH). Three groups of 32 male Wistar rats were treated as follows: group 1 (G1) had the colon denervated
Brazilian Journal of Medical and Biological Research. Publicado em: 14/02/2008
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12. Estudo da ação antineoplástica do ipê roxo na carcinogênege induzida pelo azoximetano em camundongos
The Purple Ipe (Tabebuia avellanedae), a tree of the Bignoniacea family found in Brazil, is known by the popular medicine as antitumoral agent against some neoplasias, between them the colorretal cancer. The objective of the present work is experimentally to study the antitumoral action of β- lapachone, that is an extracted constituent of purple ipe, in
Publicado em: 2007