3 Animal Models
Mostrando 25-36 de 489 artigos, teses e dissertações.
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25. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
AbstractHyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammatio
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 10/11/2015
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26. Experience report on teaching surgical technique without animal use
PURPOSE: To report the experience of the school in implementing the 3 Rs replace, reduce and refine; showing time and assembling cost of the experimental models used in the teaching of Surgical Technique and Experimental Surgery.METHODS: Assembly time and costs of models: grafts and flaps performed in pork belly, model of intestinal anastomosis and jejunosto
Acta Cir. Bras.. Publicado em: 2015-05
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27. Generation of 3D ultrasound biomicroscopic images: technique validation and in vivo volumetric imaging of rat lateral gastrocnemius
Introduction Ultrasound biomicroscopy (UBM) is a technique for generating high-resolution images, with frequencies from 20 MHz to 100 MHz. For example, it has been used in animal research related to models of injury and diseases that mimic human conditions. With a three-dimensional ultrasound (3D) image system, an organ can be viewed at various angles and t
Res. Biomed. Eng.. Publicado em: 2015-04
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28. Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transc
Genet. Mol. Biol.. Publicado em: 2015-03
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29. Comparison of breeding value prediction for two traits in a Nellore-Angus crossbred population using different Bayesian modeling methodologies
The objectives of this study were to 1) compare four models for breeding value prediction using genomic or pedigree information and 2) evaluate the impact of fixed effects that account for family structure. Comparisons were made in a Nellore-Angus population comprising F2, F3 and half-siblings to embryo transfer F2 calves with records for overall temperament
Genet. Mol. Biol.. Publicado em: 14/11/2014
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30. Mibefradil reduces blood glucose concentration in db/db mice
OBJECTIVE: Numerous recent studies suggest that abnormal intracellular calcium concentration ([Ca2+]i) is a common defect in diabetic animal models and patients. Abnormal calcium handling is an important mechanism in the defective pancreatic β-cell function in type 2 diabetes. T-type Ca2+ channel antagonists lower blood glucose in type 2 diabetes, but the
Clinics. Publicado em: 2014-01
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31. Socio-demographic and clinical characteristics of pregnant and puerperal crack-cocaine using women: preliminary data
Background The literature provides several studies on the effects of cocaine when exposed to the fetus. However, the majority of these data comes from animal models. Objective The objective of this study is to present socio-demographic and clinical data in crack-cocaine using pregnant women and their babies, as compared to non-users. Methods Cross-sectional
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2014
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32. Potentiation of a novel palladium (II) complex lethality with bee venom on the human T-cell acute lymphoblastic leukemia cell line (MOLT-4)
Background : Although honeybee venom (BV) has been reported to induce apoptosis in different types of cancerous cells, its synergistic effects with customary anti-cancer drugs remain largely unknown. In the present study, we evaluated the cytotoxic effect of BV alone (as a natural product) and the synergistic cytological effects of this component in combina
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 03/10/2013
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33. A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay
Current therapy for pancreatic cancer is multimodal, involving surgery and chemotherapy. However, development of pancreatic cancer therapies requires a thorough evaluation of drug efficacy in vitro before animal testing and subsequent clinical trials. Compared to two-dimensional culture of cell monolayer, three-dimensional (3-D) models more closely mimic nat
Braz J Med Biol Res. Publicado em: 22/07/2013
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34. FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system
OBJECTIVE: Available chemotherapy presents poor control over the development of metastatic melanoma. FTY720 is a compound already approved by the Food and Drug Administration for the treatment of patients with multiple sclerosis. It has also been observed that FTY720 inhibits tumor growth in vivo (experimental models) and in vitro (animal and human tumor ce
Clinics. Publicado em: 2013-07
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35. Genetic and non-genetic effects on calf vigor at birth and preweaning mortality in Nellore calves
The objective of the present study was to evaluate the genetic and non-genetic effects that influence vigor at birth and preweaning mortality in Nellore calves. A total of 11,727 records of births that occurred between 1978 and 2006, offspring of 363 sires, were analyzed. Poor calf vigor at birth (VB) and preweaning mortality divided into stillbirth (SB), ea
R. Bras. Zootec.. Publicado em: 2013-06
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36. Determinação do impacto do oversizing da endoprótese sobre a aorta torácica. Estudo experimental em porcos / Impact of stent-graft oversizing on the thoracic aorta: experimental study in a porcine model
Introduction: The use of endovascular techniques to treat the various disorders of the aorta has supplanted traditional open techniques, and is particularly promising in trauma1. The traumatic rupture of the aorta is the second leading cause of death by traffic accident2, 3, and repair of these lesions with endoluminal stents has showed lower mortality and p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/11/2012