1 Trypanosoma Brucei
Mostrando 1-12 de 237 artigos, teses e dissertações.
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1. Trypanosoma cruzi XRNA granules colocalise with distinct mRNP granules at the nuclear periphery
BACKGROUND Eukaryotic ribonucleoprotein (RNP) granules are important for the regulation of RNA fate. RNP granules exist in trypanosomatids; however, their roles in controlling gene expression are still not understood. XRNA is a component of granules in Trypanosoma brucei but has not been investigated in Trypanosoma cruzi. OBJECTIVES This study aimed to inv
Mem. Inst. Oswaldo Cruz. Publicado em: 18/06/2018
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2. Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme
Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis. Compound 7 is not used clinically due to its mutagenic and genotoxic properties, but has been largely used as a lead compound. Here, we compared the activity of 7 with its 4H-1,2,4-triazole bioisostere
Mem. Inst. Oswaldo Cruz. Publicado em: 18/03/2014
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3. Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
Protein tyrosine phosphatases (PTPs) play an essential role in the regulation of cell differentiation in pathogenic trypanosomatids. In this study, we describe a PTP expressed by the non-pathogenic protozoan Trypanosoma rangeli (TrPTP2). The gene for this PTP is orthologous to the T. brucei TbPTP1 and Trypanosoma cruzi (TcPTP2) genes. Cloning and expression
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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4. Characterization of anti-silencing factor 1 in Leishmania major
Anti-silencing factor 1 (ASF1) is a histone chaperone that contributes to the histone deposition during nucleosome assembly in newly replicated DNA. It is involved in chromatin disassembly, transcription activation and in the cellular response to DNA damage. In Leishmania major the ASF1 gene (LmASF1) is located in chromosome 20 and codes for a protein showin
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-05
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5. Estudos com a poli-A binding protein 1 de Trypanosoma brucei sugerem nova função nos eventos de splicing e exportação nuclear / Studies with Trypanosoma brucei poly(A)-binding protein 1 suggest a novel function in splicing and nuclear export events
Protozoa of the genus Trypanosoma infect millions of people every year and collectively contribute to the human misery by causing several neglected tropical diseases. Several intriguing molecular pathways are found in these parasites also, rendering them particularly attractive for biochemical investigation. This unique eukaryotic cells lack mechanisms to co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/12/2011
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6. Moléculas bioativas em quilópodes. / Bioactive molecules in chilopods.
Os artrópodes constituem o grupo mais diverso do Reino Animal, apresentando uma distribuição muito ampla nos ecossistemas e habitats. O fato de esses animais terem mudado muito pouco durante sua evolução e estarem bem adaptados aos ambientes inóspitos e com uma alta presença de microorganismos patogênicos, torna interessante a realização de estudos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/09/2011
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7. Localização genômica e subcelular dos membros da família de fosfatidilinositol quinases em Trypanosoma cruzi / Genomic and subcellular localization of the members of phosphatidylinositol kinase family in Trypanosoma cruzi
The identification of signaling molecules and the elucidation of signal transduction processes of Trypanosoma cruzi are required for understanding the host-parasite interaction and physiological processes of the parasite. However, little is yet known about signal transduction and signaling pathways that occur in the parasite, since most efforts focused on si
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/07/2011
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8. Expressão heteróloga e caracterização bioquímica e biológica da NTPDase-1 de Leishmania infantum chagasi / Heterologous expression and biochemical and biological Characterization of Leishmania infantum chagasi NTPDase-1.
A Leishmaniose Visceral (LV) é um grave problema de saúde pública em vários países do mundo incluindo o Brasil. Atualmente tem se observado um número crescente de casos no homem e no cão, sendo este último considerado principal reservatório doméstico responsável pela manutenção da doença em periferias de grandes cidades. O foco central deste tr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/02/2011
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9. Proteínas quinases envolvidas na regulação do estresse em Trypanosoma. / Protein kinases involved in stress regulation in Trypanosoma.
Protozoa of the genus Trypanosoma have a complex life cycle alternating between vertebrate and invertebrate hosts. The adaptation to different environmental conditions requires rapid changes in gene expression to fill up the morphological and metabolic requirements for survival. Very little is known about the mechanisms that control these changes and the sig
Publicado em: 2010
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10. Estudos sobre o componente ORC1/CDC6 da maquinaria de pré-replicação dos tripanossomas. / Studies of the Orc1/Cdc6 component of pre-replication machinery of trypanosomes.
Em eucariotos, a origem de replicação é reconhecida por um complexo ORC, a proteína Cdc6 e outras proteínas. Nos tripanossomas, encontramos somente uma proteína similar a Orc1 e Cdc6, que chamaremos de Orc1/Cdc6. Nesta tese serão descritos os estudos realizados sobre Orc1/Cdc6 do Trypanosoma cruzi e do Trypanosoma brucei. As proteínas recombinantes d
Publicado em: 2010
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11. Cl gene cluster encoding several small nucleolar RNAs: a comparison amongst trypanosomatids
Small nucleolar RNAs (snoRNAs) are small non-coding RNAs that modify RNA molecules such as rRNA and snRNA by guiding 2'-O-ribose methylation (C/D box snoRNA family) and pseudouridylation reactions (H/ACA snoRNA family). H/ACA snoRNAs are also involved in trans-splicing in trypanosomatids. The aims of this work were to characterise the Cl gene cluster that en
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-05
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12. AnÃlise da expressÃo e localizaÃÃo subcelular dos homÃlogos TbEIF4G1 e TbEIF4G2 do fator de iniciaÃÃo da traduÃÃo eIF4G de Trypanosoma brucei
Os tripanosomatÃdeos, agentes causadores de enfermidades de impacto mundial, se destacam dos demais eucariotos por apresentarem um conjunto de processos moleculares Ãnicos, inclusive a ausÃncia de controle da sua transcriÃÃo. Dessa forma, o controle de sua expressÃo gÃnica deve ocorrer apÃs a transcriÃÃo. Assim, um ponto importante de controle à a
Publicado em: 2009