1 3 4 Oxadiazole
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Heterostructured Langmuir-Blodgett Films of Ruthenium Bipyridine with 1,3,4-Naphthooxadiazole-Derived Amphiphile Complex as a Charge Storage Electrode
The molecular control in Langmuir-Blodgett (LB) films may be exploited in charge storage electrodes provided a suitable choice of molecular architecture and components is made. In this paper, we employed a naphtyl-1,3,4-oxadiazole amphiphile (NFT1) and its complex [Ru(bpy)2NFT1]PF6 (RuNFT1) (bpy = 2,2’-bipyridine) in heterostructured LB films in a proof-of
J. Braz. Chem. Soc.. Publicado em: 2020-11
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2. Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway
We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, vasoactive intestinal peptide (VIP), and corticotropin-releasing factor (CRF) peptide in this phenomenon.
Braz J Med Biol Res. Publicado em: 04/10/2018
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3. 1,2,4- and 1,3,4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the four isomeric forms of oxadiazole rings as well as discuss the differences and similarities between them. In addition, we discuss aspects on their reactivity that justify
J. Braz. Chem. Soc.. Publicado em: 2018-03
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4. ABORDAGEM DIDÁTICA PARA O DESENVOLVIMENTO DE MOLÉCULAS BIOATIVAS: REGRA DOS CINCO DE LIPINSKI E PREPARAÇÃO DE HETEROCICLO 1,3,4-OXADIAZOL EM FORNO DE MICRO-ONDAS DOMÉSTICO
In Brazil, the development of new chemical entities (NEQ) is still limited to small advances in the academic and public research sectors, the authors understand that this is a sector of the pharmaceutical industry that needs encouragement. Accepting that education transforms society, educate students in the development of bioactive molecules, it’s a way to
Quím. Nova. Publicado em: 2018-01
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5. Design, Synthesis, Pharmacological Evaluation and Molecular Docking Studies of Substituted Oxadiazolyl-2-Oxoindolinylidene Propane Hydrazide Derivatives
The manuscript describes design and synthesis of novel oxadiazolyl-2-oxoindolinylidene propane hydrazides as amide tethered hybrids of indole and oxadiazole and their evaluation for anti-inflammatory and analgesic activity. The compounds were synthesized following five step reaction to yield fifteen derivatives as 3-(5-substituted-1,3,4-oxadiazol-2-yl)-N'-[2
J. Braz. Chem. Soc.. Publicado em: 2016-11
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6. Synthesis, spectral analysis and pharmacological study of N'- substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
ABSTRACT A series of molecules bearing multiple functional groups were synthesized to study their antibiotic effect against Gram-positive and Gram-negative bacteria and lipoxygenase activity as well. 2,4-Dimethylcarbolic acid (1) was refluxed with ethyl 2-bromoacetate to synthesize ethyl 2-(2,4-dimethylphenoxy)acetate (2). Compound 2 was converted to the cor
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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7. Convergent synthesis of new N -substituted 2-{[5-(1H -indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as suitable therapeutic agents
resumo Uma série de acetamidas 2-{[5-(1H-indol-3-ilmetil)-1,3,4-oxadiazol-2-il]sulfanila} N-substituídas (8a-w) foi sintetizada em três fases. A primeira etapa envolveu a conversão sequencial de ácido 2-(1H-indol-3-il)acético (1) a éster (2), seguido por hidrazida (3) e, finalmente, a e ciclização na presença de CS2 e KOH alcoólico produziu 5-(1H-
Braz. J. Pharm. Sci.. Publicado em: 2015-12
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8. Synthesis and antimicrobial properties of 1,3,4-oxadiazole analogs containing dibenzosuberane moiety
Uma série de dez novos análogos de 1,3,4-oxadiazóis contendo uma parte dibenzosuberano foram sintetizados usando tanto uma aproximação de síntese linear, quanto convergente. Todos os compostos foram caracterizados por espectrometria de massas, espectroscopias no infravermelho (IR), de ressonância magnética nuclear de ¹H (¹H NMR ) e 13C (13C NMR) e
J. Braz. Chem. Soc.. Publicado em: 2014-01
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9. Synthesis and testing of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives for antifungal activity against selected Candida Species
Uma série de 21 derivados, 1,3,4-oxadiazolinas, foi sintetizada pela ciclização de N-acilhidrazonas com anidrido acético e avaliada in vitro quanto à sua atividade antifúngica contra seis espécies de Candida: Candida albicans (ATCC 90028 e LM V-42), Candida krusei (ATCC 6258 e LM 12 C) e Candida tropicalis (ATCC 13803 e LM 14). As espécies de Candida
J. Braz. Chem. Soc.. Publicado em: 2013-01
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10. Planejamento, síntese e avaliação da atividade anti-T. cruzi de derivados furfurilidênicos com estruturas azometínica e oxadiazolínica / Design, synthesis, identification and anti-Trypanosoma cruzi activity evaluation of furfurylidene azomethine and oxadiazole derivatives
The search for alternative therapies for the treatment of Chagas disease presents great importance, since there are only two currently available drugs, nifurtimox and benznidazole. Both have considerable adverse effects and, in Brazil, is used only benznidazole. Nitro-heterocyclic compounds with activity against Trypanosoma cruzi, the causative agent of Chag
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2012
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11. Participação dos canais para potássio nos efeitos cardiovasculares induzidos por um novo composto 1,3,4- oxadiazol. / Participation of potassium channels in cardiovascular effects induced by a novel compound 1,3,4-oxadiazole.
Os efeitos farmacológicos de OXDINH, um derivado 1,3,4-oxadiazol obtido por síntese orgânica, sobre o sistema cardiovascular e a participação dos canais para K+ nesta resposta, foram estudados em ratos usando técnicas combinadas in vivo e in vitro. Em anéis de artéria mesentérica superior isolada de rato, com endotélio funcional, OXDINH (10-10 10-4
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2012
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12. Lanthanide nitrates as Lewis acids in the one-pot synthesis of 1,2,4-oxadiazole derivatives
Neste trabalho relatamos o uso de nitratos de lantanídeos [Ln(NO3)3] atuando como catalisador na síntese de uma única etapa de derivados de 3-benzoíla- e 3-acetila-1,2,4-oxadiazóis a partir de cetonas, nitrilas e ácido nítrico. Este é o primeiro exemplo da síntese em única etapa de preparação de derivados benzoíla e acetila-1,2,4-oxadiazóis, us
J. Braz. Chem. Soc.. Publicado em: 31/07/2012