Mdx Mice
Mostrando 13-24 de 81 artigos, teses e dissertações.
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13. L-arginine administration : the effect on myocardial fibrosis and increase of the carcinogenesis in mice mdx / Administração de L-arginina : efeitos sobre a fibrose miocardica e aumento da carcinogenese em camundongos mdx
The Duchenne Muscle Dystrophy (DMD) is a myopathy characterized by dystrophin absence, which is a structural protein of the plasma membrane. The dystrophin absence leads to functional alterations followed by necrosis in the skeletal and cardiac muscle fiber. As the patients grow older, about 40% of them develop cardiomyopathy due to progressive myocardial fi
Publicado em: 2009
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14. Influence of the ascorbic acid in the muscular degeneration process in dystrophic mice / Influencia do acido ascorbico no processo de degeneração muscular em camundongos distroficos
A peroxidação lípidica causada pelo aumento de espécies reativas de oxigênio (EROs) no período que antecede o início da degeneração muscular no camundongo mdx, sugere que o estresse oxidativo pode ser um dos mecanismos primários da degeneração muscular distrófica, ao invés de ser um efeito secundário deste processo. No presente trabalho verifi
Publicado em: 2009
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15. Myocardial fibrosis prevention and accumulation of lipofuscin in myocities cardiac of mdx mice / Prevenção da fibrose miocardica e acumulo de lipofuscina em cardiomiocitos de camundongos mdx
The Duchenne Muscle Dystrophy is a progressive myopathy caused by recessive autossomic disease connected to the gender, which attacks male kids, and involves to motor disability in the property, leading to death around the second decade of life. It is caused by an alteration in the codifier gene of the protein dystropin, which maintains the integrity of the
Publicado em: 2009
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16. Analise da plasticidade sinaptica em motoneuronios alfa medulares no modelo experimental da distrofia muscular tipo Duchenne / Alpha motoneuron imput changes in dystrophic MDX mice after sciatic nerve transection
A distrofia muscular de Duchenne (DMD) é uma doença de caráter recessivo, onde o cromosso X sofre mutações e não codifica o gene responsável pela produção da distrofina. Atinge aproximadamente 1 em cada 3500 nascidos vivos. A distrofina, juntamente com o complexo glicoproteína-distrofina, tem as funções de manter as ligações entre o citoesquele
Publicado em: 2009
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17. Avaliação do padrão de degeneração e regeneração muscular em diferentes modelos murinos para distrofias musculares progressivas / Study of degeneration and regeneration pathways, in mice models for muscular dystrophies
The muscular dystrophies are a heterogeneous group of genetic diseases characterized by progressive and irreversible degeneration of skeletal muscles. Muscle weakness is the consequence of an imbalance between successive cycles of degeneration and regeneration, with further replacement of the degraded muscle fibers by adipose and connective tissues. Several
Publicado em: 2009
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18. Influencia de bloqueadores de canais de calcio no processo de degeneração/regeneração muscular em camundongos ditroficos MDX / The influence iof calcium channel blockers in the process of muscular degeneration/regeneration in mdx mice
The lack of dystrophin in dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy leads to sarcolemmal breakdown and enhanced calcium influx followed by muscle degeneration.In this work, we examined whether the calcium channel blockers diltiazem and verapamil could protect dystrophic muscles from degeneration/regeneration. Mdx mice (n=32;
Publicado em: 2008
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19. Mechanisms of protection against myonecrosis in extraocular muscles of the mdx mice / Mecanismos de proteção a mionecrose nos musculos extra-oculares de camundongos distroficos mdx
Duchenne muscular dystrophy is one of the most common hereditary diseases. Abnormal calcium ion handling renders dystrophic muscle fibers more susceptible to necrosis. In the mdx mice, extraocular muscles (EOM) are protected and do not undergo myonecrosis. We investigated whether this protection is related to an increased expression of calcium-binding protei
Publicado em: 2008
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20. Ação de antiinflamatorios não-esteroides na degeneração/regenação de fibras musculares distroficas de camundongos mdx / Nonsteroidal antiinflamatory influence in the degeneration/regeneration cycles of mdx mice dystrophic muscle fibers
Em fibras musculares distróficas de camundongos mdx e na distrofia muscular de Duchenne (DMD), a deficiência da distrofina provoca lesão do sarcolema e degeneração muscular. Esta deficiência está associada a alterações na estabilidade do sarcolema e aumento dos níveis intracelulares de cálcio, que podem provocar mionecrose. O mecanismo exato que p
Publicado em: 2008
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21. Estudo microbiológico fecal de linhagens de camundongos, de estirpes de E. coli e do meio ambiente em biotérios / Fecal microbiologic study of mice lineages, E. coli strains and the environment in laboratory animal facilities
Mice have been largely used at experiences since 17o century, so their microbiological quality should be investigated and kept safety in order to avoid they become ill or die during an investigation and dont transmit zoonosis to those who handle them; this is important in order to make the results presented in the experience be reliable. The Escherichia coli
Publicado em: 2008
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22. Protection from myonecrosis, and expression of SERCA1 and calsequestrin in dystrophic laryngeal muscles / Musculos laringeos distroficos : proteção a mionecrose, expressao de SERCA1 e calsequestrina
Duchenne muscular dystrophy (DMD) and mdx mice, a model for DMD, is characterized by the lack of dystrophin expression and muscle fiber necrosis. Some muscle are enigmatically protected and admitted that an elevated expression of calcium-binding proteins. The intrinsic laryngeal muscles (ILMs) share many anatomical and physiological properties with extra-ocu
Publicado em: 2007
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23. Cromolyn therapy decreases dystrophic skeletal muscle necrosis / Influencia do cromoglicato de sodio no processo de necrose muscular em camundongos mdx jovens
Neste trabalho foi verificado se o cromoglicato de sódio protege os músculos distróficos de camundongos mdx da necrose. Camundongos mdx (n=8) com 14 dias de vida pós-natal, antes do início dos ciclos de degeneração e regeneração, foram tratados com cromoglicato de sódio (50mglKg/dia; intraperitoneal) por 16 dias. Camundongos mdx (n=8) com a mesma i
Publicado em: 2006
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24. A importancia do complexo de sinalização associado a quinase de adesão focal (FAK) em corações de camundongos MDX submetidos a sobrecarga pressora
Mechanisms involved in the transduction of mechanical stimuli into biochemical signals in the myocardium are not fully understood. Experimental evidences suggested an important role of the sarcomeric cytoskeleton and extra-sarcomeric in transduction of mechanical stimuli into biochemical signals in the cardiomyocytes. Presumably, these structures participate
Publicado em: 2004