Antimalarials
Mostrando 1-12 de 54 artigos, teses e dissertações.
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1. Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective an
Rev. Soc. Bras. Med. Trop.. Publicado em: 16/05/2019
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2. Simultaneous Determination of Antimalarial Agents by LC-MS/MS and Its Application to Evaluation of Fixed-Dose Tablets
We developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to quantify the antimalarials artesunate (ARS) and mefloquine (MFQ) in fixed-dose tablets. The detection was performed by a triple-quadrupole mass spectrometer in multiple reaction monitoring (MRM) in positive ion mode via electrospray ionization. Chromatographic se
J. Braz. Chem. Soc.. Publicado em: 2017-04
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3. Lupus tumidus: a report of two cases
Abstract Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression. Histopathology reveals perivascular and periannexal lymphohistiocytic infiltrates in the papillary and reticular dermis and interstitial mucin depos
An. Bras. Dermatol.. Publicado em: 2016-10
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4. Highly active ozonides selected against drug resistant malaria
Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs. Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials. We
Mem. Inst. Oswaldo Cruz. Publicado em: 30/05/2016
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5. Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: Aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon
Infusions of Aspidosperma nitidum (Apocynaceae) wood bark are used to treat fever and malaria in the Amazon Region. Several species of this family are known to possess indole alkaloids and other classes of secondary metabolites, whereas terpenoids, an inositol and the indole alkaloids harmane-3 acid and braznitidumine have been described in A. nitidum . In t
Mem. Inst. Oswaldo Cruz. Publicado em: 06/12/2013
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6. In vitro and in vivo antimalarial activity and cytotoxicity of extracts, fractions and a substance isolated from the Amazonian plant Tachia grandiflora (Gentianaceae)
Tachia sp. are used as antimalarials in the Amazon Region and in vivo antimalarial activity of a Tachia sp. has been previously reported. Tachia grandiflora Maguire and Weaver is an Amazonian antimalarial plant and herein its cytotoxicity and antimalarial activity were investigated. Spectral analysis of the tetraoxygenated xanthone decussatin and the iridoi
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-06
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7. Saúde pública, inovação farmacêutica e propriedade intelectual: o desenvolvimento de um novo medicamento contra a malária no Brasil / Public health, pharmaceutical innovation and intelectual property: the development of a new medicine against malaria in Brazil
This thesis aims to study the relationship between intellectual property, innovation and public health, considering the case of the consortium for the development of the fixed-dose combination artesunate-mefloquine (ASMQ) for the treatment of malaria. The genesis of this initiative is part of a historical moment (late 1990s and early 2000s), when studies hig
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/09/2012
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8. New approaches in antimalarial drug discovery and development: a review
Malaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem has since been aggravated by a decreased sensitivity of Plasmodium vivax to chloroquine. This review discusses strategies for evaluating the antimalarial activity of new compounds in vi
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-11
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9. Síntese de análogos da febrifugina / Synthesis of antimalarial febrifugina analogues
Neste trabalho sintetizamos alguns análogos à febrifugina (1), alcaloide inicialmente isolado a partir de extratos da erva Chang shan (Dichroa febrífuga) e detentor de potente atividade antimalárica. Foram sintetizados análogos na forma racêmica em que se variou o tamanho do anel heterocíclico saturado, a ausência de substituinte e presença de um á
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/09/2011
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10. Biossíntese de vitamina E nos estágios intraeritrocitários de P. falciparum. / Vitamin E biosynthesis in intraerythrocytic stages of Plasmodium falciparum.
The study of isoprenoid biosynthesis in Plasmodium falciparum by 2C-methyl-D-erythritol-4-phosphate pathway (MEP) it is presented as a therapeutic target once that it is absent in humans. It was found in intraerythrocytic stages of P. falciparum the biosynthesis of isoprenoids by the MEP pathway. The shikimate and MEP pathways are the precursors of biosynthe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2011
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11. Aplicação da microextração em fase liquida na análise de alguns fármacos antimaláricos e respectivos metabólitos em plasma / Application of liquid-phase microextration to the analysis of some antimalarial drugs and their metabolites in plasma
Currently, malaria is the main parasitic infection and shows worldwide distribution. Among therapeutic options used, chloroquine (CQ), mefloquine (MQ) and, more recently, artemether (ART) have been standing out. According to the literature, pharmacokinetic studies of these drugs have been hampered by the lack of proper methods of analysis in biological fluid
Publicado em: 2009
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12. Desenvolvimento de métodos analíticos para quantificação de artemeter e lumefantrina em comprimidos de dose fixa combinada e em plasma humano.
Nowadays, malaria is the worlds most incident parasitic infection. The artemisinin based combination therapy (ACT) has been advocated as a promising treatment for malaria and artemetherlumefantrine (20+120 mg) is the main recommended association in endemic areas. In spite of the wide use of this association, the scientific literature is still scarce regardin
Publicado em: 2009