Y1 Cells
Mostrando 13-24 de 2709 artigos, teses e dissertações.
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13. Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
Abstract Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods: In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018
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14. Estudio Ab-initio de propiedades estructurales, elásticas y electrónicas de nanohilos core/shell
ABSTRACT This Zinc oxide (ZnO) is widely used in different electronic devices due to its thermal, electronic, and piro-piezoelectric properties. Some of these properties are noticeable improvement at the nanoscale, specially when ZnO together with other material create heterostructures. Recently, core/shell nanowires have been synthesized in order to raise t
Matéria (Rio J.). Publicado em: 19/07/2018
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15. Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss
Occupational noise-induced hearing loss (ONIHL) is a prevalent occupational disorder that impairs auditory function in workers exposed to prolonged noise. However, serum microRNA expression in ONIHL subjects has not yet been studied. We aimed to compare the serum microRNA expression profiles in male workers of ONIHL subjects and controls. MicroRNA microarray
Braz J Med Biol Res. Publicado em: 11/01/2018
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16. Characterization of air-liquid interface culture of A549 alveolar epithelial cells
Alveolar epithelia play an essential role in maintaining the integrity and homeostasis of lungs, in which alveolar epithelial type II cells (AECII) are a cell type with stem cell potential for epithelial injury repair and regeneration. However, mechanisms behind the physiological and pathological roles of alveolar epithelia in human lungs remain largely unkn
Braz J Med Biol Res. Publicado em: 11/12/2017
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17. Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LPS)-induced apoptosis and inflammation in human renal tubular epithelial cells, and to evaluate the potential r
Braz J Med Biol Res. Publicado em: 11/12/2017
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18. Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations
ABSTRACT Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the
Braz J Infect Dis. Publicado em: 2017-12
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19. Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x]
A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, i
Braz J Med Biol Res. Publicado em: 13/11/2017
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20. Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes
Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Therefore, we investigated the association between vitamin D levels and asthma outcomes in a murine model of obese asthma. We also evaluated NLRP3 inflammas
Braz J Med Biol Res. Publicado em: 13/11/2017
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21. Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms
The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hemangioma cells, and determined the effects of HIF-1α on the hemangi
Braz J Med Biol Res. Publicado em: 02/10/2017
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22. Down-regulation of single-stranded DNA-binding protein 1 expression induced by HCMV infection promotes lipid accumulation in cells
The objective of this study was to observe the infection of human cytomegalovirus (HCMV) to human umbilical vein endothelial cells, and its effect on the expression of single-stranded DNA-binding protein (SSBP1) and on lipid metabolism in endothelial cells. We screened the differential expression of mRNAs after HCMV infection by suppression subtractive hybri
Braz J Med Biol Res. Publicado em: 12/09/2017
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23. Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension
Intrauterine growth retardation (IUGR) is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated
Braz J Med Biol Res. Publicado em: 12/09/2017
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24. Silencing of augmenter of liver regeneration inhibited cell proliferation and triggered apoptosis in U266 human multiple myeloma cells
Augmenter of liver regeneration (ALR) is a thermostable cytokine that was originally identified to promote the growth of hepatocytes. This study was conducted to explore the expression and function of ALR in multiple myeloma (MM), a common hematologic malignancy. Real-time PCR and western blot analysis were performed to detect the expression of ALR in U266 h
Braz J Med Biol Res. Publicado em: 31/08/2017