Xenotransplantation
Mostrando 1-12 de 69 artigos, teses e dissertações.
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1. Xenotransplantation: on the way to Clinical Application?
Braz. J. Cardiovasc. Surg.. Publicado em: 22/07/2019
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2. Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells
Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various types of cancer. However, its role on human oral squamous cell carcinoma (OSCC) cells is still not well elucidated. In the present study, we investigated the effect of BITC on apoptosis and invasion of SCC9 cells, and its underlying mechanisms in vitro and in vivo
Braz J Med Biol Res. Publicado em: 08/04/2019
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3. Hematological and biochemical profile of BALB/c nude and C57BL/6 SCID female mice after ovarian xenograft
Abstract Hematological and biochemical profile studies help to evaluate functional changes of animals used in experiments. The aim of this study was to determine the hematological and biochemical profile of immunosuppressed BALB/c nude and C57BL/6 SCID mice after bovine ovarian xenotransplantation. Therefore, a total of 74 female mice were divided into four
An. Acad. Bras. Ciênc.. Publicado em: 25/10/2018
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4. Human islet xenotransplantation in rodents: A literature review of experimental model trends
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studi
Clinics. Publicado em: 2017-04
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5. Histological and functional analysis of inner ear stem cell xenotransplantation in the cochlea of guinea pigs with induced hearing loss / Análise histológica e funcional de xenotransplante de células-tronco da orelha interna de camundongos em cócleas de cobaias com perda auditiva induzida
Background: In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here we investigate whether, after transplantation, neonatal mouse inner ear stem cells (mIESCs) can survive and integrate into basal turns of neomycin-injured guinea pig cochleas. We also studied the potential effects of th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/09/2012
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6. Infectious Disease Issues in Xenotransplantation
Xenotransplantation, the transplantation of living organs, tissues, or cells from one species to another, is viewed as a potential solution to the existing shortage of human organs for transplantation. While whole-organ xenotransplantation is still in the preclinical stage, cellular xenotransplantation and extracorporeal perfusion applications are showing pr
American Society for Microbiology.
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7. Detection of Infectious Baboon Cytomegalovirus after Baboon-to-Human Liver Xenotransplantation
Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known transmissibility and clinical significance of human cytomegalovirus (HCMV) infection after allotransplantation led us to evaluate whether baboon cytomegalovirus (BCMV) tra
American Society for Microbiology.
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8. Xenotransplantation and tolerance.
The application of xenotransplantation faces daunting immunological hurdles, some of which might be overcome with the induction of tolerance. Porcine organs transplanted into primates are subject to several types of rejection responses. Hyperacute rejection mediated by naturally occurring xenoreactive antibodies and complement can be overcome without toleran
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9. Infection of Nonhuman Primate Cells by Pig Endogenous Retrovirus
The ongoing shortage of human donor organs for transplantation has catalyzed new interest in the application of pig organs (xenotransplantation). One of the biggest concerns about the transplantation of porcine grafts into humans is the transmission of pig endogenous retroviruses (PERV) to the recipients or even to other members of the community. Although no
American Society for Microbiology.
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10. The demise of UKXIRA and the regulation of solid‐organ xenotransplantation in the UK
The new regulations on xenotransplantation pay insufficient attention to the broad ethical (and legal) problems raised by this technique and that the abandonment of a national body with overall regulatory authority in this area is a mistake.
BMJ Group.
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11. Monitoring for Presence of Potentially Xenotic Viruses in Recipients of Pig Islet Xenotransplantation
This study represents a long-term follow-up of human patients receiving pig islet xenotransplantation. Eighteen patients had been monitored for up to 9 years for potentially xenotic pig viruses: pig endogenous retrovirus, pig cytomegalovirus, pig lymphotropic herpesvirus, and pig circovirus type 2. No evidence of viral infection was found.
American Society for Microbiology.
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12. Intracellularly Expressed Single-Domain Antibody against p15 Matrix Protein Prevents the Production of Porcine Retroviruses
The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endoge
American Society for Microbiology.