Wnt
Mostrando 1-12 de 534 artigos, teses e dissertações.
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1. Wnt3a but not CDX-2 expression is associated with differentiated thyroid cancer
SUMMARY OBJECTIVE: Thyroid neoplasm incidence has increased worldwide, mostly due to the advancements in medical imaging and screening rates. The aberrant Wnt/β-catenin pathway has been identified as a key mechanism, and it has also been related to the metastatic activity of differentiated thyroid cancer. We aimed to verify the difference in the expression
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Fibroblast morphology, growth rate and gene expression in facial melasma
Abstract Background: In addition to melanocytic hyperfunction, changes are observed in the upper dermis of melasma, and fibroblasts play a central role in collagen synthesis and pigmentation induction. Objective: To explore the morphology, growth rate, and gene expression profile of fibroblasts from the skin with melasma in comparison to fibroblasts from t
Anais Brasileiros de Dermatologia. Publicado em: 2022
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3. Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells
Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2. Interleukin (IL)-17A is an immune modulator able to shape macrophage phenotypes. Wnt/β-catenin is a developmental signaling pathway that plays crucial roles in morphogene
Braz J Med Biol Res. Publicado em: 2020-08
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4. A flutuação do gene da APC na via de sinalização WNT com deleção de adenina na polipose adenomatosa do cólon está associada ao câncer colorretal
RESUMO O câncer colorretal é uma das neoplasias malignas mais importantes na classificação dos cânceres gastrointestinais. Um dos fatores predisponentes no âmbito molecular para esse câncer é através da via de sinalização WNT, que está associada a um grande número de genes diferentes. Portanto, neste estudo, objetivamos investigar se a mutação
J. Coloproctol. (Rio J.). Publicado em: 2020-04
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5. Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and chronic renal disease: a cross-sectional study
ABSTRACT BACKGROUND: Diabetic nephropathy is a common complication of chronic kidney disease (CKD). Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade
Sao Paulo Med. J.. Publicado em: 2020-03
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6. Baicalein restrains proliferation, migration, and invasion of human malignant melanoma cells by down-regulating colon cancer associated transcript-1
Baicalein (BAI) is an acknowledged flavonoids compound, which is regarded as a useful therapeutic pharmaceutical for numerous cancers. However, its involvement in melanoma is largely unknown. This study aimed to examine the anti-melanoma function of BAI and unraveled the regulatory mechanism involved. A375 and SK-MEL-28 were treated with BAI for 24 h. Then,
Braz J Med Biol Res. Publicado em: 25/11/2019
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7. EFFECTS OF CONTUSION AND EXHAUSTIVE EXERCISE ON MG53, PTRF IN SKELETAL MUSCLE OF RATS
RESUMO Objetivos Estudar os efeitos da contusão e do exercício exaustivo sobre a expressão de MG53, PTRF, Pax7 e β-catenina no músculo esquelético de ratos e revelar o mecanismo de reparo da lesão desses músculos. Métodos Quarenta e dois ratos Wistar machos foram divididos randomicamente em 7 grupos, com 6 ratos em cada grupo. Todos os grupos fo
Rev Bras Med Esporte. Publicado em: 11/11/2019
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8. Small RNA sequencing reveals microRNAs related to neuropathic pain in rats
The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles in the pathogenesis and development process of neuropathic pain. The rat model of neuropathic pain caused by spared nerve injury (SNI) was established in Sprague-Dawley male rats, followed by small RNA sequencing of the L3–L6 d
Braz J Med Biol Res. Publicado em: 16/09/2019
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9. Osteogenesis imperfecta in Brazilian patients
Abstract Osteogenesis Imperfecta (OI) is a heterogeneous genetic disorder characterized by bone fragility and fracture. Mutations in 20 distinct genes can cause OI, and therefore, the genetic diagnosis of OI is frequently difficult to obtain because of the great number of genes that can be related with this disease. Studies that report the most frequently mu
Genet. Mol. Biol.. Publicado em: 15/08/2019
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10. Inhibitory effect of Astragalus polysaccharide on osteoporosis in ovariectomized rats by regulating FoxO3a /Wnt signaling pathway
Abstract Purpose: To investigate inhibitory effect of Astragalus polysaccharide (APS) on osteoporosis in ovariectomized rats by regulating FoxO3a/Wnt2 signaling pathway. Methods: Postmenopausal osteoporosis (PMOP) animal model was developed by excising the bilateral ovaries of rats. The model rats were administered with APS (200 mg/kg, 400 mg/kg, 800 mg/
Acta Cir. Bras.. Publicado em: 03/06/2019
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11. 6-Bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway
This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively af
An. Acad. Bras. Ciênc.. Publicado em: 21/03/2019
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12. Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression
Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed to clarify the functions of emodin in hypoxia-induced i
Braz J Med Biol Res. Publicado em: 25/02/2019