White Matter Lesion
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Oligoclonal bands in the cerebrospinal fluid and increased brain atrophy in early stages of relapsing-remitting multiple sclerosis
OBJECTIVE: To determine if the presence of oligoclonal bands (OB) at early stages of multiple sclerosis was associated with higher brain atrophy, when compared with patients without OB. METHODS: Relapsing-remitting multiple sclerosis (RRMS) patients with less than two years of disease onset and OB detection in cerebrospinal fluid (CSF) were included. SIENAX
Arquivos de Neuro-Psiquiatria. Publicado em: 2012-08
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2. White matter lesions in Fabry disease before and after enzyme replacement therapy / Lesões da substância branca na doença de Fabry antes e depois da terapia de reposição enzimática : um seguimento de 2 anos
Objetivo: Relatar os achados neurológicos e de imagem do sistema nervoso central (SNC), observados durante 24 meses de tratamento de reposição enzimática (ERT) com agalsidase-alfa, em pacientes com a doença de Fabry (FD). Método: 8 pacientes foram incluídos; 6 completaram 24 meses de ERT. Os dados foram obtidos aos 0, 12 e 24 meses de ERT. Lesões de
Publicado em: 2010
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3. Esclerose multipla : correlação clinica, liquido cefalorraquiano e neuroimagem
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) of unknown aetiology, which first manifestations occur in adolescence or in young adulthood, after multifocal demyelination caused by an autoimmune and inflammatory process. The clinical evolutive sequence can take the relapsing-remitting, secondarily progressive and primary pro
Publicado em: 2003
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4. Damage to White Matter Fiber Tracts in Acute Spatial Neglect
Previous statistical voxelwise lesion-behavior mapping (VLBM) studies have demonstrated that spatial neglect is associated with cortical and subcortical gray matter damage. However, it has also been suggested that the disorder may result from white matter injury. Our aim was to investigate the white matter connectivity in a large sample of 140 stroke patient
Oxford University Press.
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5. Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain
Intracerebral administration of the excitotoxin ibotenate to newborn mice induces white-matter lesions, mimicking brain lesions that occur in human preterm infants. Nociceptin (NC), also called orphanin FQ, is the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor and does not bind classical high-affinity opioid receptors. In the present study,
American Society for Clinical Investigation.
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6. Panencephalopathic type of Creutzfeldt-Jakob disease: primary involvement of the cerebral white matter
Eight necropsy cases of a “panencephalopathic” type of Creutzfeldt-Jakob disease (CJD) in the Japanese are reported. The reasons why this type should be discussed separately from other types of CJD are that there is primary involvement of the cerebral white matter as well as the cerebral cortex, and that the white matter lesion of one Japanese human brai
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7. Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination.
An unusual biphasic central nervous system disease developed in 3-week-old Swiss outbred mice after intracerebral inoculation of the DA strain of Theiler's murine encephalomyelitis virus. Nine to 20 days postinfection 86% of mice became paralyzed, and approximately one-half of these animals survived. During this period neuronal necrosis and microglial prolif
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8. Memory loss from a subcortical white matter infarct.
Clinical disorders of memory are believed to occur from the dysfunction of either the mesial temporal lobe, the mesial thalamus, or the basal forebrain. Fibre tract damage at the level of the fornix has only inconsistently produced amnesia. A patient is reported who suffered a cerebrovascular accident involving the posterior limb of the left internal capsule
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9. Grading white matter lesions on CT and MRI: a simple scale.
We developed and tested a simple three-point scale for grading white matter lesions in anterior and posterior regions of the brain. Twenty four CT scans and 24 MRI scans were separately judged by 11 and five observers, respectively, on the presence and severity of white matter lesions. The observers were radiologists and neurologists. For CT scans, these per
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10. Quantitative magnetic resonance imaging in multiple sclerosis: the effect of high dose intravenous methylprednisolone.
Magnetic resonance imaging was performed on 50 patients with clinically definite or probable multiple sclerosis before and 15 days after starting treatment with intravenous methylprednisolone (0.5 g daily for 5 days). Scans were abnormal in 49 patients. New lesions had appeared on the second scan in nine individuals and in seven a single pre-existing lesion
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11. Subacute necrotizing encephalomyelopathy of infancy and childhood
Subacute necrotizing encephalomyelopathy appears to be a distinct pathological entity occurring in infancy and childhood. The neurological manifestations are diverse but the course is one of progressive deterioration. The aetiology is not known and no treatment is available. Histologically the lesion is characterized by multiple areas of necrosis and is rema
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12. Pathology of radiation myelopathy
After nothing the rarity of papers describing the pathology of delayed radiation necrosis of the spinal cord, the clinical and pathological findings from four cases are presented. The main pathological features are asymmetric demyelination of the lateral columns and to a lesser degree the posterior and anterior columns of white matter, with coagulative necro