Voltage Gated Ion Channels
Mostrando 1-12 de 152 artigos, teses e dissertações.
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1. Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide to
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 03/06/2019
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2. Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?
Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological functions, such as muscle contraction, cell volume regulation,
Braz J Med Biol Res. Publicado em: 05/06/2017
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3. Dysfunctional Hyperpolarization-Activated Cyclic Nucleotide-gated Ion Channels in Cardiac Diseases
Abstract Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal-transduction cascades. The distribution, quantity and activation states of HCN
Braz. J. Cardiovasc. Surg.. Publicado em: 2016-04
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4. Purificação e caracterização da fração neurotóxica da peçonha da anêmona do mar Anthopleura cascaia / Purification and characterization of the neurotoxic fraction from the venom of the sea anemone Anthopleura cascaia
A peçonha de anêmonas do mar é uma fonte conhecida de compostos bioativos, incluindo peptídeos, que atuam em canais voltagem-dependentes. Foram descritos 4 tipos de neurotoxinas de anêmonas do mar, que atuam em canais NaV e 4 tipos que atuam em canais KV. Essas toxinas têm permitido discriminar subtipos de canais voltagem-dependentes, estreitamente rel
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/06/2012
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5. O ß-hidroxibutirato modifica os processos de ativação e inativação dos canais para sódio e potássio em corpos celulares de neurônios dos gânglios das raizes dorsais de ratos.
Under physiological conditions, the ketone bodies -hydroxybutyrate, acetoacetate and acetone are products of -oxidation of fatty acids that occurs in hepatocytes in response to hypoglycemia. This process occurs during fasting, high fat diets (such as the ketogenic diet, used in cases of drug-resistant epilepsy) and during diabetes mellitus in order to meet t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
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6. Expressão heteróloga de neurotoxinas do veneno da aranha Phoneutria nigriventer
The venom of the spider Phoneutria nigriventer contains several peptides that act on ion channels and receptors of the nervous system of insects and mammals. The toxins Tx3-6 and Tx3-4 are voltage-gated calcium channel blockers and have shown a pharmacological potential in the treatment of pain and in neuroprotection. Only small amounts of these toxins can b
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/06/2011
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7. Analysis of the inhibitory effect of eugenol on voltage-gated Na+ channels of sensory neurons. / Análise do efeito inibitório do eugenol sobre canais para Na+ ativados por voltagem em neurônios sensitivos.
The previously described inhibitory effects of eugenol (EUG) on voltage-activated Na+ channels (Nav) are not compatible with our results. We have studied the effects of EUG on macroscopic Na+ currents and compared them to the effects of lidocaine, a local anesthetic. EUG blocked both mixed (TTX-S and TTX-R) and TTX-R Na+ currents in a fast and reversible man
Publicado em: 2010
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8. A novel Kv1.1 potassium channel blocking toxin from the venom of Palamneus gravimanus (Indian black scorpion)
A peptide toxin was isolated from the venom of Palamneus gravimanus, the Indian black scorpion, to block human Kv1.1 channels expressed in Xenopus laevis oocytes. A 4.5 kD peptide (toxin), as confirmed by SDS-PAGE, was purified to homogeneity by ion exchange chromatography using CM-Sephadex C-25 followed by Sephadex G-50 gel filtration. Palamneus gravimanus
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2005-09
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9. Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels
Protein toxins from venomous animals exhibit remarkably specific and selective interactions with a wide variety of ion channels. Hanatoxin and grammotoxin are two related protein toxins found in the venom of the Chilean Rose Tarantula, Phrixotrichus spatulata. Hanatoxin inhibits voltage-gated K+ channels and grammotoxin inhibits voltage-gated Ca2+ channels.
National Academy of Sciences.
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10. Enhancement of ionic currents through voltage-gated channels in the mouse oocyte after fertilization
1. The changes of voltage-gated ion channels in the mouse oocyte after fertilization were investigated under voltage clamp.
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11. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo)
Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels share properties of voltage- and ligand-gated ion channels. In voltage-gated channels, membrane depolarization promotes the displacement of charged residues contained in the voltage sensor (S4 region) inducing gating currents and pore opening. In MaxiK channels, both voltage and micromolar
The National Academy of Sciences of the USA.
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12. Ion channels in transit: voltage-gated Na and K channels in axoplasmic organelles of the squid Loligo pealei.
Ion channels that give rise to the excitable properties of the neuronal plasma membrane are synthesized, transported, and degraded in cytoplasmic organelles. To determine whether plasma membrane ion channels from these organelles could be physiologically activated, we extruded axoplasm from squid giant axons, dissociated organelles from the cytoskeletal matr