Vasorelaxation
Mostrando 1-12 de 54 artigos, teses e dissertações.
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1. Vasorelaxant activity and acute toxicity of the ethanolic extract of Zanthoxylum rhoifolium Lam leaves
The study evaluated the vasorelaxant effect induced by the ethanolic extract of the leaves of Zanthoxylum rhoifolium Lam (EEtOH-Zr/leaves). Wistar rats were treated with the leaf extract containing a single dose of 2,000 mg / kg, v.o. After 14 days, the animals were anesthetized for blood collection and subsequent analysis of the biochemical parameters; they
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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2. Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats
Abstract Background: Curcuma longa has biological effects. Its cardiovascular activities are yet to be scientifically studied. Objectives: To investigate the vasorelaxant effects of the aqueous extract of Curcuma longa (AECL). Methods: Aortic annuli of normotensive rats, with or without endothelium, were set up in a data storage system with nutrient solut
Int. J. Cardiovasc. Sci.. Publicado em: 07/03/2019
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3. Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats
Clobenzorex is a metabolic precursor of amphetamine indicated for the treatment of obesity. Amphetamines have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension. The aim of the present study was to investigate whether the direct application of 10–9–10–5 M clobenzorex on isolated phenylephrine-precont
Braz J Med Biol Res. Publicado em: 07/08/2017
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4. Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation
Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism. Here, we investigated the role of βAR subtypes (β1AR, β2AR, and β3AR) and cAMP in maturation-dependent vasorelaxation impairment. Aortic rings from 15 Sprague-Dawley male rats (3 or 9 weeks
Braz J Med Biol Res. Publicado em: 04/07/2016
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5. Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone
in vitro to rat aortic ringsAmfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vas
Braz J Med Biol Res. Publicado em: 27/03/2015
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6. Participação da via do óxido nítrico e do cálcio no vasorrelaxamento induzido pelo flavonoide 5,7,4 trimetoxiflavona (TMF) em artéria mesentérica superior de rato. / Participation of the nitric oxide and calcium pathway in the vasorelaxant effect induced by flavonoid 5,7,4-trimethoxyflavone (TMF) in rat superior mesenteric artery.
Os efeitos farmacológicos do extrato etanólico (EPC), fase clorofórmica (FPC) e 5,7,4-trimetoxiflavona (TMF) provenientes de Praxelis clematidea, sobre anéis de artéria mesentérica superior de ratos, foram estudados. Experimentos de tensão isométrica revelaram que EPC e FPC (0,0011000 μg/mL) promoveram relaxamento dependente de concentração em
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/02/2012
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7. Erythroxylum pungens elicits vasorelaxation by reducing intracellular calcium concentration in vascular smooth muscle cells of rats
The cardiovascular effects elicited by the ethanolic extract obtained from the roots of Erythroxylum pungens O.E. Schulz, Erythroxylaceae (EEEP) and the vasorelaxant effect induced by its main tropane alkaloid (pungencine) were investigated. In normotensive rats, administration of EEEP (1, 10, 30 and 60 mg/kg i.v., randomly) produced dose-dependent hypotensi
Revista Brasileira de Farmacognosia. Publicado em: 06/01/2012
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8. Avaliação pré-clínica dos efeitos cardiovasculares induzidos pelo liofilizado do vinho tinto do Vale do Rio São Francisco em ratos abordagem in vivo e in vitro
Estudos epidemiológicos demonstram que o consumo regular de vinho está associado a um decréscimo da mortalidade global. Acredita-se que o efeito protetor seja decorrente, pelo menos em parte, da presença de polifenóis. A atividade biológica do Liofilizado do vinho tinto do Vale do São Francisco (LVTVSF) foi estudada no sistema cardiovascular usando t�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/11/2011
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9. Cardiovascular effects of monoterpenes: a review
The monoterpenes are secondary metabolites of plants. They have various pharmacological properties including antifungal, antibacterial, antioxidant, anticancer, anti-spasmodic, hypotensive, and vasorelaxant. The purpose of this research was to review the cardiovascular effects of monoterpenes. The data in this resarch were collected using the Internet portal
Revista Brasileira de Farmacognosia. Publicado em: 08/07/2011
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10. Avaliação dos efeitos induzidos pelo 2-Nitrato-1, 3-Dibutoxipropano (NDBP) sobre o sistema cardiovascular de ratos normotensos - abordagens en vivo e in vitro
Organic nitrates are nitric oxide (NO) donors used in the treatment of cardiovascular diseases mimicking the role of endogenous NO. This study evaluated organic nitrates newly synthesized from glycerin, which cardiovascular actions had not yet been investigated. Therefore, the cardiovascular effects produced by organic nitrates derived from glycerin: 2-nitra
Publicado em: 2010
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11. Involvement of nitric oxide and its up/down stream molecules in the immunity against parasitic infections
Nitric oxide (NO) is a potent mediator with diverse roles in regulating cellular functions and signaling pathways. The NO synthase (NOS) enzyme family consists of three major isoforms, which convey variety of messages between cells, including signals for vasorelaxation, neurotransmission and cytotoxicity. This family of enzymes are generally classified as ne
Brazilian Journal of Infectious Diseases. Publicado em: 2009-12
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12. Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
The objective of the present study was to assess the effects of the immunosuppressant rapamycin (Rapamune®, Sirolimus) on both resistance vessel responsiveness and atherosclerosis in apolipoprotein E-deficient 8-week-old male mice fed a normal rodent diet. Norepinephrine (NE)-induced vasoconstriction, acetylcholine (ACh)- and sodium nitroprusside (SNP)-indu
Brazilian Journal of Medical and Biological Research. Publicado em: 06/11/2009