Vascular Smooth Muscle
Mostrando 13-24 de 875 artigos, teses e dissertações.
-
13. Potential benefit of (-)-epigallocatechin-3-gallate for macrovascular complications in diabetes
Vascular problems are the most common complications in diabetes. Substantial evidence from epidemiological and pathophysiological studies show that hyperglycemia is a major risk factor for macrovascular complications in patients with diabetes. (-)-Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, is known to exert a variety of car
Braz J Med Biol Res. Publicado em: 17/08/2017
-
14. Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells
Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a control group. Real-time fluorescence quantitative PCR w
Acta Cir. Bras.. Publicado em: 2017-05
-
15. Effect of tobacco smoke on hydrogen sulfide-induced rat thoracic aorta relaxation
Levels of hydrogen sulfide (H2S), a gaseous signaling molecule, are reduced in the serum of individuals who smoke. We hypothesized that tobacco smoke influenced smooth muscle relaxation by decreasing H2S levels and this effect could also influence expression of cystathionine γ-lyase (CSE) and sulfonylurea receptor-2 (SUR-2). The aim of this study was to exp
Braz J Med Biol Res. Publicado em: 06/02/2017
-
16. Inactivated Pseudomonas aeruginosa inhibits hypoxia-induced pulmonary hypertension by preventing TGF-β1/Smad signaling
Pseudomonas aeruginosa is one of the common colonizing bacteria of the human body and is an opportunistic pathogen frequently associated with respiratory infections. Inactivated P. aeruginosa (IPA) have a variety of biological effects against inflammation and allergy. Transforming growth factor-β (TGF-β) signaling plays a critical role in the regulation of
Braz J Med Biol Res. Publicado em: 25/08/2016
-
17. Impact of free thyroxine levels and other clinical factors on bare metal stent restenosis
ABSTRACT Objective Thyroid hormones have both direct and indirect effects on thermogenesis such as modulating vascular smooth muscle cell proliferation. However, the influence of more subtle changes in thyroid hormones on coronary atherosclerosis remains a matter of speculation. Smooth muscle cells play a crucial role in the pathogenesis of in-stent resten
Arch. Endocrinol. Metab.. Publicado em: 25/08/2016
-
18. Sesquiterpene lactones from Hedyosmum brasiliense induce in vitro relaxation of rat aorta and corpus cavernosum
Abstract Hedyosmum brasiliense Miq., Chloranthaceae, has been used in Southern Brazil as a sedative, anti-inflammatory, and aphrodisiac. In this study, endothelium-intact and endothelium-denuded rat aortic rings and strips of corpus cavernosum were used to investigate the relaxant effects of an hexane fraction of leaves of H. brasiliense and its sesquiterpen
Rev. bras. farmacogn.. Publicado em: 2016-06
-
19. Assessment of endothelial function by flow-mediated dilation in diabetic patients: Effects of physical exercise
Abstract The endothelium is now recognized as an endocrine organ that acts to maintain vascular homeostasis regulating the vascular tone and structure. The endothelial cells synthetize a variety of mediators among them, the main agent is the nitric oxide (NO), a potent vasodilator. NO exerts its protective role preventing leukocyte adhesion and migration, ex
Motriz: rev. educ. fis.. Publicado em: 2016-03
-
20. α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies
ABSTRACT α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse vasculopathies such as thoracic aortic aneurysms and dissections as well as occlusive vascular
Braz. J. Cardiovasc. Surg.. Publicado em: 2015-12
-
21. Tanshinone IIA attenuates interleukin-17A-induced systemic sclerosis patient-derived dermal vascular smooth muscle cell activation via inhibition of the extracellular signal-regulated kinase signaling pathway
OBJECTIVE: Salvia miltiorrhiza has long been used to treat systemic sclerosis. Tanshinone IIA, one of the phytochemicals derived from the roots of Salvia miltiorrhiza, exhibits multiple biological activities. The present study aimed to investigate whether tanshinone IIA has an effect on the interleukin-17A-induced functional activation of systemic sclerosis
Clinics. Publicado em: 2015-04
-
22. The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis
OBJECTIVES: Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic colitis. METHODS: Forty female Wistar albino rats weighing 250-300 g were randomized into five experiment
Clinics. Publicado em: 2014-11
-
23. Low dose of green tea catechins improves endothelial function and vascular smooth muscle cell reactivity in obese women
RESUMO OBJETIVO: A alta prevalência de obesidade no mundo traz vários problemas de saúde com a disfunção endotelial como um problema frequente. Investigamos se o consumo de baixa dose de extrato de chá verde (catequinas < 200 mg/dia) pode modificar a função endotelial, o perfil lipídico, a glicemia e a insulina de jejum, a glicose plasmática pós
MedicalExpress (São Paulo, online). Publicado em: 2014-10
-
24. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain
O-GlcNAcylation is a modification that alters the function of numerous proteins. We hypothesized that augmented O-GlcNAcylation levels enhance myosin light chain kinase (MLCK) and reduce myosin light chain phosphatase (MLCP) activity, leading to increased vascular contractile responsiveness. The vascular responses were measured by isometric force displacemen
Braz J Med Biol Res. Publicado em: 15/08/2014