Uncoupling Proteins
Mostrando 1-12 de 116 artigos, teses e dissertações.
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1. Restrição alimentar intra-uterina e suas repercussões sobre o desenvolvimento da termorregulação da prole.
Background: Previous study from our laboratory has shown that intrauterine food restriction (IUFR) delayed thermoregulation of the newborns. In neonates brown adipose tissue (BAT) is essential for thermogenesis mainly due to the presence of uncoupling proteins (UCPs) and their expression can be modified by action of hormones such as thyroid hormone, leptin a
Publicado em: 2009
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2. Renal contributions to corporal homeostasis in rats : role of renal innervation / Contribuição renal para a homeostase corporal em ratos : função da inervação renal
Introdução: Os rins, em humanos, são responsáveis por 10% de todo o oxigênio consumido, pelo corpo, em 24 horas. Este consumo pode ser representativo de uma grande contribuição da parte renal para a termogênese global dos indivíduos. A termogênese global é constituída pela termogênese facultativa, a qual está associada à ativação da UCP e ca
Publicado em: 2007
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3. Efeitos do destreinamento e da dieta hiperlipidica nos mecanismo moleculares de indução de obesidade e resitencia a insulina / Effects of detraining and high-fat diet on molecular mechanisms of obesity and insulin resistance
The cessation of physical training (detraining) results in rapid fat mass accretion, gain weight and insulin resistance in both humans and animals. However, little is know about the cellular basis for the effect. The aim of this study was to investigate the PI3-kinase/Akt and CAP/Cbl signaling pathways both involved with insulin-stimulated glucose uptake in
Publicado em: 2007
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4. Identificação e caracterização de genes expressos em resposta ao estresse por baixa temperatura em cana-de-açucar
Environmental stresses represent one of the main factors limiting crop productivity, being very important studies that aim to analyze, at a molecular level, the effects caused by these stresses. In the present project, we analyzed the sugarcane gene expression profiles in response to low temperature. Initially, high-density filter arrays containing 1536 ESTs
Publicado em: 2004
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5. Proteina desacopladora de plantas : efeito do estresse oxidativo na sua expressão e atividade e reconstituição funcional da isoforma de Arabidopsis thaliana
The present work is divided in two parts: the functional reconstitution of the Arabidopsis thaZiana uncoupling protein 1 (AtPUMPI) and the expression and activity of the uncoupling protein under several abiotic stresses. AtPUMPI expression in Saccharomyces cerevisae and Escherichia coZi allowed us to confirm that this gene codes for a true uncoupling protein
Publicado em: 2003
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6. Hormônios tireóideos, UCPs e termogênese
Calor é um subproduto da transformação de energia, em suas diversas formas, durante a síntese e a utilização do ATP. Nos animais homeotérmicos, o calor derivado das funções biológicas - estando o organismo em repouso e à temperatura ambiente - é utilizado para manter o organismo próximo a 37°C. Essa termogênese obrigatória está associada à
Arquivos Brasileiros de Endocrinologia & Metabologia. Publicado em: 2000-08
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7. Activity and functional interaction of alternative oxidase and uncoupling protein in mitochondria from tomato fruit
Cyanide-resistant alternative oxidase (AOX) is not limited to plant mitochondria and is widespread among several types of protists. The uncoupling protein (UCP) is much more widespread than previously believed, not only in tissues of higher animals but also in plants and in an amoeboid protozoan. The redox energy-dissipating pathway (AOX) and the proton elec
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-03
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8. The mitochondrial uncoupling proteins
The uncoupling proteins are transporters, present in the mitochondrial inner membrane, that mediate a regulated discharge of the proton gradient that is generated by the respiratory chain, to serve functions such as thermogenesis, maintenance of the redox balance, or reduction in the production of reactive oxygen species.
BioMed Central.
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9. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
Oxidative stress and mitochondrial dysfunction are associated with disease and aging. Oxidative stress results from overproduction of reactive oxygen species (ROS), often leading to peroxidation of membrane phospholipids and production of reactive aldehydes, particularly 4-hydroxy-2-nonenal. Mild uncoupling of oxidative phosphorylation protects by decreasing
Oxford University Press.
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10. Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.
A cDNA encoding the precursor of the bovine mitochondrial phosphate carrier protein has been cloned from a bovine cDNA library using a mixture of 128 different 17-mer oligonucleotides as hybridisation probe. The protein has an N-terminal extension of 49 amino acids not present in the mature protein. This extension has a net positive charge and is presumed to
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11. A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein.
The uncoupling protein (UCP) is uniquely expressed in brown adipose tissue, which is a thermogenic organ of mammals. The UCP uncouples mitochondrial respiration from ATP production by introducing a proton conducting pathway through the mitochondrial inner membrane. The activity of the UCP is regulated: nucleotide binding to the UCP inhibits proton conductanc
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12. Alterations of G-protein coupling function in phosphoinositide signaling pathways of cells transformed by ras and other membrane-associated and cytoplasmic oncogenes.
We showed previously that transformation by cytoplasmic and membrane-associated oncogenes including ras results in uncoupling between surface stimulation by platelet-derived growth factor, bombesin, and serum and activation of intracellular phospholipase C (PLC); this uncoupling does not involve alterations at the receptor or effector enzyme levels (T. Alons