Ubiquitin
Mostrando 1-12 de 1506 artigos, teses e dissertações.
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1. Cushing disease due to a somatic USP8 mutation in a patient with evolving pituitary hormone deficiencies due to a germline GH1 splicing variant
SUMMARY We present the unique case of an adult Brazilian woman with severe short stature due to growth hormone deficiency with a heterozygous G to T substitution in the donor splice site of intron 3 of the growth hormone 1 (GH1) gene (c.291+1G>T). In this autosomal dominant form of growth hormone deficiency (type II), exon 3 skipping results in expression of
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Genome-wide identification, characterisation and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata
BACKGROUND Biomphalaria glabrata is the major species used for the study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational regulation in order to maintain cellular protein homeostasis and is related to several mechanisms, i
Mem. Inst. Oswaldo Cruz. Publicado em: 03/06/2019
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3. Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis
Multiple myeloma (MM) is a malignant neoplasm of plasma, and exhibits several harmful effects including osteolytic injuries, hypercalcemia, and immune dysfunction. Many patients with MM succumb to the underlying malignancy. An S-phase kinase-related protein 2 (Skp2) inhibitor, designated SKPin C1, has been developed and confirmed to have an inhibitory effect
Braz J Med Biol Res. Publicado em: 25/04/2019
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4. THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA
RESUMO Racional : Acredita-se que a via Wnt é uma das mais importantes da sinalização envolvidas na carcinogênese gástrica. Objetivos : Analisar a expressão das proteínas das vias Wnt canônicas e não-canônicas no carcinoma gástrico e relacionar sua expressão com as variáveisclinicopatológicas. Método : Foram coletadas 72 amostras de c
ABCD, arq. bras. cir. dig.. Publicado em: 07/01/2019
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5. Identification of potential target genes of USP22 via ChIP-seq and RNA-seq analysis in HeLa cells
Abstract The ubiquitin-specific protease 22 (USP22) is an oncogene and its expression is upregulated in many types of cancer. In the nucleus, USP22 functions as one subunit of the SAGA to regulate gene transcription. However, the genome-wide USP22 binding sites and its direct target genes are yet clear. In this study, we characterized the potential genomic b
Genet. Mol. Biol.. Publicado em: 11/06/2018
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6. Genetic transformation of Brachiaria brizantha cv. Marandu by biolistics
ABSTRACT Brachiaria brizantha is a forage grass well adapted to tropical areas and cultivated in millions of hectares in Brazil. The apomictic mode of reproduction in this species, in addition to differences in ploidy between sexual and apomictic plants, impairs crossbreeding. The development of a methodology to transform apomictic cultivars will provide an
An. Acad. Bras. Ciênc.. Publicado em: 2018-04
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7. Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents
Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Herein, we used cell c
Braz J Med Biol Res. Publicado em: 19/10/2017
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8. Plant arginyltransferases (ATEs)
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One imp
Genet. Mol. Biol.. Publicado em: 13/02/2017
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9. Identification of reference genes for gene expression normalization in safflower (Carthamus tinctorius)
ABSTRACT Safflower (Carthamus tinctorius L., Asteraceae) is an important oil crop and medicinal plant. Gene expression analysis is gaining importance in the research of safflower. Quantitative PCR has become a powerful method for gene study. Reference genes are one of the major qualification requirements of qPCR because they can reduce the variability. To id
Rev. bras. farmacogn.. Publicado em: 2016-10
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10. Six-week anaerobic training improves proteolytic profile of diabetic rats
Objective To evaluate the effect of six-week anaerobic training on the mRNA expression of genes related to proteolysis Ubb (Ubiquitin), E2-14kDa, Trim63 (MuRF1 protein) and Nfkb1 in the skeletal muscle of diabetic rats.Materials and methods Four groups were established: DE (DiabetesExercised), DS (Diabetes Sedentary), CE (Control Exercised) and CS (Control S
Arch. Endocrinol. Metab.. Publicado em: 25/09/2015
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11. Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni
Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an important role in Ub-depen
Mem. Inst. Oswaldo Cruz. Publicado em: 04/11/2013
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12. Caracterização de putativo receptor serpentino e estudos sobre a implicação do sistema de ubiquitina/proteossomo na modulação do ciclo celular de Plasmodium falciparum. / Caracterization of serpentine receptor putative and studies about the implication of ubiquitin/proteasome system in Plasmodium falciparum cell cycle.
É proposto que vias de sinalização controlem a sobrevivência e adaptação do Plasmodium, nos diferentes hospedeiros. No presente trabalho buscamos por diferentes abordagens estudar a via de sinalização de melatonina em P. falciparum. Para isso, avaliamos os níveis de RNA mensageiro de genes do sistema-ubiquitina proteossomo (UPS) bem como o perfil de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/05/2012