Ubiquitin Proteasome Pathway
Mostrando 1-12 de 242 artigos, teses e dissertações.
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1. Genome-wide identification, characterisation and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata
BACKGROUND Biomphalaria glabrata is the major species used for the study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational regulation in order to maintain cellular protein homeostasis and is related to several mechanisms, i
Mem. Inst. Oswaldo Cruz. Publicado em: 03/06/2019
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2. Plant arginyltransferases (ATEs)
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One imp
Genet. Mol. Biol.. Publicado em: 13/02/2017
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3. Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni
Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an important role in Ub-depen
Mem. Inst. Oswaldo Cruz. Publicado em: 04/11/2013
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4. Modulação do metabolismo muscular em camundongos exercitados e suplementados com leucina / Modulation of muscle metabolism by exercise and leucine supplementation in mice
We investigated the effects of chronic physical training, associated or not with leucine supplementation, on protein and glucose metabolism in soleus muscle of Swiss mice. Half of the mice (T) performed a 12 weeks protocol of swimming exercise, 1h/day, 5 days/week, bearing no overload, and the other half remained sedentary (C). Additionally, half of the C an
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/02/2012
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5. Análise bioquímica inicial do proteassoma em populações do Trypanosoma cruzi com diferentes fenótipos de resistência ao benzonidazol
Differences in susceptibility to benznidazole (Bz) and nifurtimox (NFX) among populations of Trypanosoma cruzi may explain, at least in part, the differences in efficacy of treatment of Chagas disease. The proteasome has an important role in the degradation of normal proteins, damaged, mutated, or denatured, including the degradation of regulatory proteins o
Publicado em: 2010
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6. Efeito do treinamento físico aeróbico sobre a atrofia muscular associada à insuficiência cardíaca: contribuição do sistema ubiquitina proteassoma dependente de ATP / Effects of aerobic exercise training on skeletal muscle atrophy associated with heart failure: role of ubiquitin-proteasome pathway
A atrofia está associada ao aumento da degradação protéica em doenças sistêmicas, sendo o sistema proteolítico ubiquitina proteassoma (SUP) uma das principais vias envolvidas. Contudo, pouco é conhecido sobre a contribuição do SUP à atrofia desencadeada pela insuficiência cardíaca (IC). Sabendo dos benefícios do treinamento físico aeróbico (T
Publicado em: 2010
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7. Associação entre o proteassoma e o inibidor de protease BTCI : caracterização fisico-química e efeitos moleculares em células de câncer de mama (MCF-7)
Dietas ricas em leguminosas têm sido associadas à baixa incidência de câncer em populações humanas, sendo essas plantas, ricas em inibidores de proteases. O BTCI (black-eyed pea trypsin/chymotrypsin inhibitor) é um inibidor de protease da família Bowman-Birk, isolado de sementes da leguminosa Vigna unguiculata (feijão-de-corda), que inibe a tripsina
Publicado em: 2010
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8. Effect of the triiodothyronine (T3) and the thyroid receptor beta selective agonist GC-24 upon rat skeletal muscle trophism: expression of proteasome-dependent genes. / Efeito da triiodotironina (T3) e do agonista TRb seletivo GC-24 sobre o trofismo muscular esquelético de ratos: aspectos envolvendo a proteólise dependente de proteassoma.
Triiodothyronine (T3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms a/pha (TRa) and beta (TRI3). Abnormalities in skeletal muscle function have been associated with increased leveis of T3, which is a major sarcopenia (Ioss of sarcomeres). Although the phenomenon of sarcopenia induced by T3 has
Publicado em: 2008
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9. Caracterização das subunidades catalíticas do proteassoma 20S em cepas de Trypanosoma cruzi susceptíveis e resistentes ao benzonidazol
Chagas disease is caused by Trypanosoma cruzi. According to WHO, in Latin America, 16-18 million people is infected with this protozoan. Due the involvement of the proteasome in the cellular biology of the T. cruzi and the low efficiency of the drugs used in the individuals treatment with Chagas disease, we believed that the characterization of the catalytic
Publicado em: 2007
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10. Expression of USP2a and study of its interaction with clathrin in human oral squamous carcinoma and prostate cancer cells / Estudo da expressão da enzima desubiquitinante USP2a e de sua interação com a proteina clatrina em celulas derivadas de carcinomas espinocelulares bucais e de prostata humanos
The ubiquitin (Ub)-proteasome pathway controls cellular protein turnover by degrading targeted intracellular proteins tagged with poly-Ub chains. Ubiquitination is a reversible process and the deubiquitinating enzymes (DUBs) are proteases that specifically cleave off Ub from Ub-protein conjugates. They can act in a preproteasomal level removing the poly-Ub t
Publicado em: 2007
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11. Screening for suppressors of temperature sensitivity in a yeast mutant defective in vacuolar protein degradation
Vps33p is a member of the Sec1/munc18-like protein (SM protein) family involved in vesicular protein transport to the yeast vacuole. It is part of a high molecular weight complex which is required for homotypic vacuole fusion, and participates in Golgi-to-endosome and endosome-to-vacuole transport steps. Deletions in the vps33 gene result in severe vacuolar
Genetics and Molecular Biology. Publicado em: 2003
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12. The ubiquitin-proteasome pathway: review of a novel intracellular mechanism of muscle protein breakdown during sepsis and other catabolic conditions.
SUMMARY BACKGROUND DATA: Patients with sepsis and other catabolic conditions, such as severe trauma, cancer, and fasting, suffer significant loss of body protein, the majority of which originates from skeletal muscle. Recent evidence suggests that muscle protein breakdown during sepsis is caused by upregulated activity in the ubiquitin-proteasome pathway and