Ubiquinone
Mostrando 1-12 de 237 artigos, teses e dissertações.
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1. Benfotiamina e Mito Q protegem ilhotas pancreáticas de rato em cultura dos efeitos pró-apoptóticos dos produtos finais de glicação avançada (AGEs) / Benfotiamine and Mito Q protect rat pancreatic islets in culture from pro-apoptotic effects of advanced glycation end products
A perda da função das células beta acelera a deterioração do controle metabólico em pessoas com diabetes tipo 2. Além da lipo- e da glicotoxicidade, os AGEs parecem contribuir para esse processo, promovendo a apoptose das ilhotas pancreáticas. Em outros tecidos, os AGEs interagem com seu receptor específico (RAGE), produzindo espécies reativas de o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/03/2012
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2. Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human host. Isoprenoids are a large and highly diverse group of natural products with many functions and their synt
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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3. Development of an in vitro model of expanded ataxin-3 cytotoxic effects and evaluation of different therapeutic strategies to control of these effects / Desenvolvimento de um modelo in vitro dos efeitos citotóxicos da ataxina-3 expandida e avaliação de diferentes estratégias terapêuticas para o controle desses efeitos
Spinocerebellar ataxia-3 (SCA3), also known as Machado-Joseph disease (MJD), belongs to a group of neurodegenerative disorders caused by expansion of a polyglutamine stretch, called polyglutamine diseases. MJD is the most frequent inherited autosomal dominant ataxia in many countries. Clinical manifestations are varied, including abnormal motor coordination
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/02/2010
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4. Clonagem, caracterização e expressão de genes envolvidos na síntese de compostos isoprenóides em Eucalyptus grandis
Isoprenoids are essential to all organisms and are the most structurally and functionally diverse group of plant metabolites. In plants, more than 30,000 compounds of this class were identified to date. All plants produce isoprenoids that can play essential roles as carotenoids, chlorophylls and plastoquinone (photosynthesis); ubiquinone (respiration); regul
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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5. Inibição, por sinvastatina, da respiração mitocondrial de biopsias de musculo esqueletico e figado de ratos / Inhibition by sivastatin of mitochondrial respiration from skeletal muscle and liver rat biopsies
Inibidores da 3-hidroxi-3-metilglutaril-CoA redutase (estatinas) são fármacos utilizados para diminuir os níveis plasmáticos de colesterol e são, geralmente, seguros e bem tolerados. Ocasionalmente esses fármacos induzem miotoxicidade, como miopatia e rabdomiólise, e hepatotoxicidade. Neste trabalho investigou-se o mecanismo, in vitro e in vivo, pelo
Publicado em: 2010
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6. Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor of the second enzyme of the MEP pathway, 1-deoxy-D-xylulose-5-phosphate reductoisomerase. We analyzed the effe
Memórias do Instituto Oswaldo Cruz. Publicado em: 2007-06
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7. Aspectos bioquÃmicos e ultraestruturais de Cunninghamella elegans cultivada em meio contendo naftaleno
In the present work the isolate of Cunninghamella elegans (UCP 542), was studied to evaluate the growth behavior in naphthalene medium. The ultrastructure and the ubiquinone systems were also analyzed. The results demonstrated the capacity of the isolate to grow in the presence of the hydrocarbon, however, exhibiting variations in the growth profile. The nap
Publicado em: 2004
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8. Contribuição para o estudo da linhagem Neurospora sp isolada de beiju de mandioca
Several strains of Neurospora sp were isolated from beiju which is used for production of tiquira in various regions of the state of Maranhão. All isolated strains, including Nelfrospora sitophila ATCC 46892 wich was also isolated from beiju by Park et alii in 1982 have produced fruity aroma that was identified as ethy hexanoate. In this research was studie
Publicado em: 1995
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9. Ubiquinone Function in Neurospora crassa
Mitochondria of cytoplasmic respiratory mutants [mi-1] (poky) and [mi-4] contain about a fourfold molar excess of ubiquinone as compared to the wild-type strain of Neurospora crassa. In the wild type and [mi-1] cultures the concentration of ubiquinone remains constant during the exponential and stationary phase of growth. In [mi-4] cultures it markedly decre
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10. Role of ubiquinone in hydrogen-dependent electron transport in Rhizobium japonicum.
Direct evidence for the involvement of ubiquinone in H2 oxidation by Rhizobium japonicum was demonstrated; H2 reduced ca. 80% of the extractable ubiquinone. The inhibitor 2-n-heptyl-4-hydroxyquinoline-N-oxide blocked electron transport at a site between ubiquinone and the cytochromes. The results showed that no cytochrome component mediates electron flow fro
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11. Inhibition of Oxygen Utilization and Destruction of Ubiquinone by Ultraviolet Irradiation of Thiobacillus thiooxidans1
Ultraviolet (UV) irradiation inhibited sulfur oxidation by cells of Thiobacillus thiooxidans. Sulfur-oxidizing activity decreased as the exposure time to UV light increased. A loss of the ability of cells of fix CO2 paralleled the loss of sulfur-oxidizing activity. UV light photoinactivated ubiquinone purified from T. thiooxidans. The same percentage of sulf
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12. Primary acceptor in bacterial photosynthesis: obligatory role of ubiquinone in photoactive reaction centers of Rhodopseudomonas spheroides.
Reaction centers were found to bind two ubiquinones, both of which could be removed by o-phenanthroline and the detergent lauryldimethylamine oxide. One ubiquinone was more easily removed than the other. The low-temperature light-induced optical and electron paramagnetic resonance (EPR) changes were eliminated and restored upon removal and readdition of ubi