Type I Interferon
Mostrando 1-12 de 450 artigos, teses e dissertações.
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1. Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type
Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) express
Rev. Soc. Bras. Med. Trop.. Publicado em: 18/07/2019
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2. An Alternative Inactivant for Rift Valley Fever Virus using Cobra Venom-derived L-Amino Oxidase, which is Related to its Immune Potential
ABSTRACT Vaccine improvement depends on the formulation, adjuvant type and inactivant used. The type of formulation may interfere with immunogenicity. The present work aimed to evaluate the inactivation activity and related immune potential of the Cobra venom-derived LAO enzyme compared to the currently used inactivants (BPL and formalin) for both animal and
Braz. arch. biol. technol.. Publicado em: 31/10/2016
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3. Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
Dengue is an acute febrile disease caused by the mosquito-borne dengue virus (DENV) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. Severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. In the present study we measured type
Mem. Inst. Oswaldo Cruz. Publicado em: 24/05/2016
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4. Comparative study of lymphocytes from individuals that were vaccinated and unvaccinated against the pandemic 2009-2011 H1N1 influenza virus in Southern Brazil
ABSTRACTINTRODUCTION:While no single factor is sufficient to guarantee the success of influenza vaccine programs, knowledge of the levels of immunity in local populations is critical. Here, we analyzed influenza immunity in a population from Southern Brazil, a region with weather conditions that are distinct from those in the rest of country, where influenza
Rev. Soc. Bras. Med. Trop.. Publicado em: 2015-10
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5. Molecular characterization of the complement C1q, C2 and C4 genes in Brazilian patients with juvenile systemic lupus erythematosus
OBJECTIVE: To perform a molecular characterization of the C1q, C2 and C4 genes in patients with juvenile systemic lupus erythematosus. METHODS: Patient 1 (P1) had undetectable C1q, patient 2 (P2) and patient 3 (P3) had decreased C2 and patient 4 (P4) had decreased C4 levels. All exons and non-coding regions of the C1q and C2 genes were sequenced. Mononuclea
Clinics. Publicado em: 2015-03
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6. Células dendríticas plasmocitoides, dendrócitos dérmicos fator XIIIa positivos, macrófagos e expressão da forma induzida da óxido nítrico sintase na resposta tecidual cutânea de leishmaniose tegumentar americana / Plasmacytoid dendritic cells, Factor XIIIa-positive dermal dendrocytes, macrophages and inducible nitric oxide synthase expression in American tegumentary leishmaniasis skin lesions
Em todas as formas clínicas da leishmaniose tegumentar americana os macrófagos são as células efetoras mais importantes na destruição do parasita intracelular. As células dendríticas são células apresentadoras de antígeno localizadas nos sítios de inoculação, como pele e mucosa. Os dendrócitos dérmicos Fator XIIIa positivos são células deri
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/08/2012
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7. Transferência gênica de p19Arf e interferon-b em células de melanoma. / Gene transfer of p19Arf and interferon-b in melanoma cells.
O melanoma maligno é uma forma de câncer com alto índice de morte devido, em parte, à falta de tratamentos eficazes e à sua tendência de formar metástases. Nosso grupo tem desenvolvido vetores virais para a transferência gênica de fatores anti-tumorais e, inicialmente, foi construído um vetor adenoviral, AdPG, no qual a expressão do transgene é c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/09/2011
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8. An experimental protocol for the establishment of dogs with long-term cellular immune reactions to Leishmania antigens
Domestic dogs are considered to be the main reservoirs of zoonotic visceral leishmaniasis. In this work, we evaluated a protocol to induce Leishmania infantum/Leishmania chagasi-specific cellular and humoral immune responses in dogs, which consisted of two injections of Leishmania promastigote lysate followed by a subcutaneous inoculation of viable promastig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-03
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9. Papel do IFN- e da iNOS na patogênese do dengue experimental
Dengue is currently the most important mosquito-borne disease that affects humans and constitutes a serious world health problem. The lack of specific treatment and vaccine, and the incipient knowledge about pathogenesis contribute to the growing numbers of cases. A major limitation in the field of DENV research is the lack of animal models that mimic the hu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/06/2009
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10. Determinação da sensibilidade e especificidade de teste de liberação de interferon-gama por linfócitos ativos estimulados por antígenos específicos do Mycobacterium tuberculosis em crianças / Evaluation of the sensibility and the specificity of an interferon-gamma release assay after lymphocyte stimulation by specific Mycobacterium tuberculosis antigens in children
INTRODUÇÃO: A tuberculose é um problema grave de saúde pública, acometendo indivíduos em todas as faixas etárias e em todos os estratos socioeconômicos. Apesar de estarem sob grande risco de adoecimento, as crianças carecem de meios diagnósticos sensíveis e específicos. Neste estudo avaliou-se em crianças a acurácia de um teste baseado na dosag
Publicado em: 2009
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11. Evaluation of the natural killer cytotoxicity and the levels of cytokines in rats with type I diabetes mellitus
Type I diabetes mellitus (insulin-dependent DM = IDDM) is a chronic disease characterized by specific destruction of pancreatic beta cells, resulting in an absolute lack of insulin. Immune mechanisms, genetic susceptibility, and environmental factors are all implicated in the pathogenesis of Type 1 diabetes. This study was aimed at determining the efficiency
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-12
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12. Participation of cytokines in the necrotic-inflammatory lesions in the heart and skeletal muscles of Calomys callosus infected with Trypanosoma cruzi
Calomys callosus, a sylvatic reservoir of Trypanosoma cruzi, when infected with the Colombian strain (Biodeme Type III, T. cruzi I ) develops necrotic-inflammatory lesions and intense early fibrogenesis in the heart and skeletal muscles, that spontaneously regress. Participation of pro-inflammatory and pro-fibrogenic cytokines, such as tumor necrosis factor-
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-08