Tumoral Progression
Mostrando 13-24 de 46 artigos, teses e dissertações.
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13. ImunoexpressÃo de metaloproteinases 2 e 14 e do inibidor TIMP-2 no cÃncer gÃstrico dos tipos intestinal e difuso / Immunoexpression of metalloproteinases 2 and 14 and the inhibitor TIMP-2 in gastric cancer of intestinal and diffuse types
As metaloproteinases-2 (MMP-2) e -14 (MMP-14) e o inibidor tecidual de metaloproteinases tipo 2 (TIMP-2) participam de modo fundamental na transiÃÃo epitelial-mesenquimal e progressÃo tumoral-linfonodal de muitos tipos de cÃncer, inclusive o gÃstrico. O objetivo deste trabalho à avaliar a expressÃo das trÃs enzimas no carcinoma gÃstrico e metÃstase
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2011
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14. Peptídeos Potencialmente Úteis no Tratamento do Câncer de Mama e o Envolvimento de Componentes da Matriz Extracelular na Resistência ao Trastuzumab..
HER2 is a member of epidermal growth factor family of receptors that is an essential mediator of cell proliferation and differentiation. In breast cancer patients, HER2 overexpression is associated with disease aggressiveness, chemo and hormone therapy resistance and poor prognosis. Currently, a HER2 specific monoclonal antibody named trastuzumab, was develo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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15. HOXB5 expression in oral squamous cell carcinoma
Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE: The present study investigated the expression of HOXB5 in
Journal of Applied Oral Science. Publicado em: 2011-04
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16. Estudo dos efeitos da terapia fotodinâmica na progressão tumoral e em modelos celulares tridimensionais / Study of the effects of photodynamic therapy on tumor progression and in three-dimensional cellular models.
Melanoma is the type of skin cancer with poor prognosis due to its high probability of suffering metastases. Currently there are few effective treatments for the this, and the survival of patients with metastases is very low, around 8 months, with cure rates of these conditions do not exceed 1%. Photodynamic therapy (PDT) is a therapeutic modality selective
Publicado em: 2010
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17. Estudo comparativo do efeito da Echinácea purpúrea e sorafenibe em células de adenocarcinoma renal humano em cultura / Comparative study of the effect of Echinacea purpurea and sorafenib in human renal adenocarcinoma cells in culture
Introduction: The renal cell carcinoma (CR) is relatively rare compared to other cancers. One of the most potent tumor mitogen, vascular endothelial growth factor, VEGF is regulated by numerous pathways, especially Ras and Akt, which are targets of many therapeutic agents, among them sorafenib. These signaling pathways play an important role in the developme
Publicado em: 2010
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18. Envolvimento dos oncogenes BRAF, PIK3CA e AKT1 e do microRNA supressor de tumor let-7 na transformação maligna e progressão tumoral tiroidiana. / Involvement of BRAF, PIK3CA and AKT1 oncogenes and let-7 tumor supressor gene in malignant tranformation and progression oh thyroid cancer.
Neste estudo, geramos ensaios de espectrometria de massa para detecção de 111 mutações nos genes RET, BRAF, NRAS, HRAS, KRAS, PIK3CA e AKT1 e avaliamos inúmeras linhagens celulares e tumores tiroidianos. Mostramos que as mutações dos genes BRAF e RAS refletem prognósticos distintos e que as mutações BRAF são altamente prevalentes em câncer metast
Publicado em: 2009
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19. Componentes da resposta inflamatória aguda que favorecem a progressão do melanoma e, modelo murino. / Components of the acute inflammatory response that promote the progression of melanoma in a murine model
Chronic inflammation is one of the main factors that predispose to cancer development and contribute to tumor progression. However, some studies show that acute inflammation is also able to generate a microenvironment favorable to the growth of certain tumors. In our laboratory, Correa et al. showed that injection of a large amount of apoptotic cells creates
Publicado em: 2009
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20. Estudos estruturais e funcionais da proteina stanniocalcina-1 humana, um novo marcador de microambiente de leucemia / Structural and functional studies of human protein stanniocalcina-1, a new microenvironmental marker of leukemia
Staniocalcins (STCs) represent a small family of glycoprotein hormones found in all vertebrates composed by STC1 and STC2, which have been initially implicated in calcium homeostasis and also recently implicated in several other processes. Stanniocalcin-1 (STC1), the first member found, was originally discovered in bony fishes and later identified in humans
Publicado em: 2009
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21. Avaliação da progressão tumoral do câncer de laringe associada à infecção pelo Papilomavírus Humano (HPV) / Evaluation of tumor progression in laryngeal carcinoma associated with human Papilomavirus (HPV) infection.
Para que ocorra a transição do epitélio normal de laringe para carcinoma escamoso é necessário um processo de múltiplas etapas tal como exposição prolongada ao fumo e álcool e uma possível associação à infecção pelo HPV. Vários tipos de marcadores moleculares vêm sendo estudados na carcinogênese da laringe, entre eles proteínas associadas
Publicado em: 2009
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22. Polimorfismos dos genes HLA e regiões promotoras do TNF- alfa -238 e -308 como fatores de sucetibilidade a psoriase e gravidade da doença / HLA and TNF-Alpha promoter regions -238 and -308 polymorphisms and marks of susceptibility to psoriasis and severety of the disease
Psoriasis is an erythematous, scaly inflammatory dermatosis with a complex immunologic basis. The strongest genetic marker for psoriasis is HLA-Cw*06. Polymorphisms in the TNF-a promoter region, especially replacement of guanine with adenine in positions -238 and -308 are related to higher TNF-a production and higher risk for psoriasis in Caucasoid populatio
Publicado em: 2009
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23. Expression of homeobox genes in oral squamous cell carcinoma cell lines, stimulated with EGF and TGF-beta / Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta
Homeobox genes, vital to many aspects related with cellular growth and differentiation, had been described as deregulated in some cancers. Their role in carcinogenesis, mainly oral squamous cell carcinomas, remains unclear and poorly characterized. Thus, this study had the purpose to evaluate, in cell cultures, the expression profile of six homeobox genes (A
Publicado em: 2008
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24. Avaliação da angiogenese e da linfangiogenese durante a progressão tumoral do carcinoma ex-adenoma pleomorfico / Study of the angiogenesis and lymphangiogenesis during tumor progression of carcicoma ex-pleomorphic adenoma
Carcinoma ex-adenoma pleomórfico (CXAP) é uma neoplasia geralmente de alto grau, com risco moderado para metástase cervical. O objetivo do trabalho foi analisar a vascularização tumoral sanguínea e linfática numa série de CXAP, que representam as diferentes fases da seqüência adenoma-carcinoma. Em oito CXAP precoces (intracapsulares ou minimamente
Publicado em: 2007