Tumor Suppressor Protein P53
Mostrando 1-12 de 442 artigos, teses e dissertações.
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1. PPARγ induces growth inhibition and apoptosis through upregulation of insulin-like growth factor-binding protein-3 in gastric cancer cells
Peroxisome proliferator activator receptor-gamma (PPARγ) is a ligand-activated transcriptional factor involved in the carcinogenesis of various cancers. Insulin-like growth factor-binding protein-3 (IGFBP-3) is a tumor suppressor gene that has anti-apoptotic activity. The purpose of this study was to investigate the anticancer mechanism of PPARγ with respe
Braz J Med Biol Res. Publicado em: 13/01/2015
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2. Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer
A subgroup of tumor that has received attention is triple-negative breast cancer (TNBC), which presents phenotype of negative estrogen receptor, negative progesterone receptor and has no overexpression of HER2. TP53 acts as a tumor suppressor limiting the proliferation of damaged cells. A polymorphic site (rs1042522) of TP53 encodes either an arginine or a p
Braz. arch. biol. technol.. Publicado em: 2014-12
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3. Scientific comment on tumor suppressor p53 protein expression: prognostic significance in patients with low-risk myelodysplastic syndrome
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-06
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4. Tumor suppressor p53 protein expression: prognostic significance in patients with low-risk myelodysplastic syndrome
BACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-06
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5. The TP53 fertility network
The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guardian of the genome", TP53 occupies a central node in stress response networks. The p53 protein has a key role as transcr
Genet. Mol. Biol.. Publicado em: 2012
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6. Assessment of staging factors in squamous cell carcinoma of the esophagus, and of immunohistochemical factors related to apoptosis and p53 / Avaliação de fatores de estadiamento em carcinoma epidermoide do esôfago e de fatores imuno-histoquímicos relacionados a apoptose e p53
O carcinoma epidermoide do esôfago continua sendo a principal neoplasia maligna esofágica na população brasileira. Os objetivos desta investigação foram: avaliar a imuno-expressão de um grupo de proteínas relacionadas à via intrínseca da apoptose (bax, APAF-1 e citocromo c) e da proteína p53 em um grupo de carcinomas epidermoides do esôfago; conf
Publicado em: 2011
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7. Prognostic impact of p16, cyclin D1, CDK4, pRb, p53 and p21 expression in head, neck and trunk melanomas / Expressão imuno-histoquímica das proteínas p16, ciclina D1, CDK4, pRb, p53 e p21 em melanomas cutâneos de cabeça, pescoço e tronco e sua relação com prognóstico
O melanoma cutâneo é a neoplasia de pele de maior mortalidade. A imprevisibilidade de sua evolução é uma de suas características principais, o tratamento do tumor primário é, atualmente, de pouca morbidade e, na doença disseminada, as opções terapêuticas são pouco eficazes. É fundamental a pesquisa de marcadores tumorais que permitam a previsã
Publicado em: 2010
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8. Evolutionary origins of human apoptosis and genome-stability gene networks
Apoptosis is essential for complex multicellular organisms and its failure is associated with genome instability and cancer. Interactions between apoptosis and genome-maintenance mechanisms have been extensively documented and include transactivation-independent and -dependent functions, in which the tumor-suppressor protein p53 works as a ‘molecular node�
Publicado em: 2010
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9. Isolated familial somatotropinoma: 11Q13-LOH and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis
OBJECTIVE: Non-pituitary tumors have been reported in a subset of patients harboring germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene. However, no detailed investigations of non-pituitary tumors of AIP-mutated patients have been reported so far. PATIENTS: We examined a MEN1- and p53-negative mother-daughter pair with acromeg
Clinics. Publicado em: 2010
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10. Leucoplasia oral: tratamento cirúrgico com laser de CO2 e de diodo e análise por imuno-histoquímica da expressão de proteínas relacionadas à carcinogênese (p53, COX-2 e EGFR) / Oral leukoplakia: surgical treatment with CO2 and diode lasers and analysis of the expression of proteins related to carcinogenesis (p53, COX-2 e EGFR) by immunohistochemistry
Oral leukoplakia (OL) is a potentially malignant lesion, defined as a white patch that cannot be characterized as any other disease of the oral mucosa. In general, OL should be treated; however no treatment available has been able to prevent malignant transformation. The aim of this study was to evaluate the efficacy of surgical treatment with CO2 and diode
Publicado em: 2010
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11. Role of p53 tumor suppressor protein for the induction of cyclooxygenase-2 carcinoma non-small cell lung: molecular and clinical aspects / O papel da proteína supressora de tumor p53 na indução de ciclooxigenase-2 em Carcinoma de Pulmão de Células Não Pequenas: aspectos moleculares e clínicos
O Carcinoma de Pulmão de Células Não Pequenas (NSCLC) é uma doença freqüentemente letal e altamente resistente à terapia oncológica convencional, como por exemplo, o tratamento quimioterápico com cisplatina e paclitaxel. A superexpressão de Ciclooxigenase-2 (COX-2) é constantemente observada em pacientes com NSCLC, estando associada ao prognóstic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/02/2009
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12. Using the Lugols solution for detection of seconds primary tumors of oral and oropharyngeal in patients with head and neck squamous cell carcinoma: correlation of histopathology findings with immunohistochemical p53 expression and metallothionein. / Uso da solução de Lugol para a detecção de segundos tumores primários de boca e orofaringe em portadores de carcinoma epidermóide na cabeça e pescoço: correlação dos achados na histopatologia com a imunoexpressão do p53 e metalotioneína
The early diagnosis of seconds primary tumors (STP) in patients already treated for carcinoma of the head and neck should be done, because enables a resolutive treatment with low morbidity. The objective of this paper is to evaluate whether chromoscopia using Lugols solution allows an improvement in the identification of malignant or pre malignant lesions in
Publicado em: 2009