Trypanocidal Activity
Mostrando 25-36 de 101 artigos, teses e dissertações.
-
25. Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
Trypanosoma cruzi infection has a large public health impact in Latin American countries. Although the transmission rates via blood transfusions and insect vectors have declined sharply in the past 20 years due to policies of the Southern Cone countries, a large number of people are still at risk for infection. Currently, no accepted experimental model or de
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-03
-
26. Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi
Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, mainly of those obtained from natural sources. This study aimed to provide an evaluation of the trypanocidal activity of 92 ethanol extrac
Revista Brasileira de Farmacognosia. Publicado em: 24/01/2012
-
27. In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared
Química Nova. Publicado em: 2012
-
28. The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi
In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-I:β-CD were 10 times more active than MTZ, demonstrating that the presence of an iodine atom on the side chain
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-12
-
29. Evaluation of the bactericidal and trypanocidal activities of triterpenes isolated from the leaves, stems, and flowers of Lychnophora pinaster
The phytochemical investigation on the aereal parts of Lychnophora pinaster Mart., Asteraceae, was carried to isolation of triterpenes. 3-O-Acetyl-lupeol (1), 3-O-acetyl-pseudotaraxasterol (2), and 3-O-acetyl-α-amyrin (3) were isolated from hexanic extract and 4,4-dimethyl-cholesta-22,24-dien-5-ol (4), α-amyrin (5), and lupeol (6) were isolated from hexani
Revista Brasileira de Farmacognosia. Publicado em: 03/06/2011
-
30. Avaliação do efeito tripanocida do eupomatenóide-5 por meio de abordagens de biologia celular e bioquímica : um possível mecanismo de ação
Chagas disease is considered a neglected disease that affects millions of people, but does not have an appropriate and effective treatment. The etiologic agent is the protozoan Trypanosoma cruzi that presents a complex life cycle alternating between a vertebrate host and an invertebrate. In the search for more effective and less toxic drugs, the research for
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2010
-
31. Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity
The essential oil of the leaves from Annona coriacea Mart., Annonaceae, was extracted by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS and GC/FID. The oil yield was 0.05% m/m. Sixty compounds were identified, in a complex mixture of sesquiterpenes (76.7%), monoterpenes (20.0%) and other constituents (3.3%). Bicyclogermacrene was its major
Revista Brasileira de Farmacognosia. Publicado em: 26/11/2010
-
32. Leishmanicidal, trypanocidal, and cytotoxic activities of endophytic fungi associated with bioactive plants in Brazil
One hundred and twenty-one isolates of endophytic fungi were recovered from leaves of the bioactive Brazilian plant species Ageratum myriadenia, Palicourea tetraphylla, Piptadenia adiantoides, and Trixis vauthieri. All fungal isolates were cultivated in liquid media and crude extracts were obtained with ethyl acetate. The crude extracts were tested in bioass
Brazilian Journal of Microbiology. Publicado em: 2010-06
-
33. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available drugs are unsatisfactory. Aromatic compounds represent an important class of DNA minor groove-binding lig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-05
-
34. Perfil tripanocida de lignanas dibenzilbutirolactônicas: avaliação das propriedades terapêuticas in vivo nas fases aguda e crônica da doença de Chagas experimental / Trypanocidal profile of dibenzylbutyrolactone lignans: evaluation of therapeutic properties in vivo, in acute and chronic experimental Chagasdisease
Chagas disease, transmitted by the protozoan Trypanosoma cruzi, affects over 18 million people in Latin America. Even though it was described 100 years ago by Carlos Chagas, it still represents a major public health problem, and there are cases in 18 developing countries located in Central and South America. In Brazil, benznidazole (Rochagan) is the only try
Publicado em: 2010
-
35. Propriedades terapêuticas de triterpenos ácidos na doença de Chagas experimental - avaliação em fase aguda da infecção / Therapeutic properties of triterpene acids in experimental Chagasdisease - evaluation in the acute phase of infection.
A doença de Chagas é um problema de saúde pública, com dados preocupantes referentes ao número de pessoas contaminadas e daquelas que ainda permanecem expostas ao risco de infecção. As doenças tropicais desafiam as pesquisas científicas, pois os medicamentos existentes apresentam sérios efeitos colaterais. As tripanossomíases são doenças de gran
Publicado em: 2010
-
36. SÍNTESE E AVALIAÇÃO DE ATIVIDADE TRIPANOCIDA DE NOVOS HETEROCICLOS DA CLASSE DOS 1,2,4-OXADIAZÓIS, DERIVADOS E ANÁLOGOS DA AMIDA NATURAL PIPERINA. / SUMMARY AND EVALUATION OF NEW trypanocidal activity Heterocycles CLASS OF 1,2,4-OXADIAZÓIS, DERIVATIVES AND ANALOGS OF NATURAL AMIDA piperine.
Este trabalho se insere numa linha de pesquisa que visa a utilização de produtos naturais abundantes e accessíveis na síntese de novas moléculas com potencial atividade anti-chagásica. Estudos recentes em nosso laboratório demonstraram a atividade antiparasitária da piperina e de uma série de derivados e análogos sobre o Trypanosoma cruzi, agente e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/09/2009