Trichostatin
Mostrando 1-12 de 178 artigos, teses e dissertações.
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1. The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells
Epigenetic mechanisms such as DNA methylation and histone modification are important in stem cell differentiation. Methylation is principally associated with transcriptional repression, and histone acetylation is correlated with an active chromatin state. We determined the effects of these epigenetic mechanisms on adipocyte differentiation in mesenchymal ste
Braz J Med Biol Res. Publicado em: 2013-05
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2. Use of chromatin modifying agents in bovine somatic cell nuclear transfer / Uso de agentes modificadores de cromatina na transferência nuclear de células somáticas em bovinos
Embora a transferência nuclear de células somáticas (TNCS) seja uma ferramenta promissora, seu amplo uso é impedido devido às altas taxas de mortalidade durante o desenvolvimento dos animais clonados. Acredita-se que a reprogramação epigenética anormal seja a principal causa desta baixa eficiência. Nós hipotetizamos que agentes modificadores de cro
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/12/2011
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3. Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
A potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation. The nuclear receptor Peroxisome Proliferator-activated receptor gamma (PPARγ) is the master regulator of adipose cell differentiation and its functional activation is currently used as a therapeutic approa
Genetics and Molecular Biology. Publicado em: 26/11/2010
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4. Mecanismos associados à perda de expressão do gene de galectina-3 em um modelo de progressão de melanoma murino / Mechanisms associated to the loss of galectin-3 gene expression in a model of murine melanoma progression
Galectin-3 is a b-galactoside-binding animal lectin, shown to be involved in tumor progression and metastasis. Galectin-3 expression has been found altered along tumor progression of different tumors. In some types of cancers such as thyroid carcinoma and bladder carcinoma, galectin-3 expression has been found increased, whereas in tumors such as breast carc
Publicado em: 2007
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5. Estudo da regulação da expressão do gene da proteína prion celular / Cellular prion protein gene expression regulation
A conversão da proteína prion celular normal (PrPc), cuja função ainda esta sob investigação, para a forma infecciosa (PrPsc) é a causa de algumas doenças neurodegenerativas em humanos e animais. Vários estudos têm sido realizados e mostram que PrPc pode participar de processos normais como memória, estresse oxidativo, neuritogênese e outros. Por
Publicado em: 2001
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6. Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-γ gene and protein expression in lupus T cells
In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-γ). We tested the hypothesis that the imbalance of these gene products reflects skewed expression of CD154, IL-10, and IFN-γ gene
The National Academy of Sciences.
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7. The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
BioMed Central.
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8. Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase
Retroviral and adeno-associated viral sequences can dramatically silence transgene expression in mice. We now report that this repression also occurs in stably infected HeLa cells when the cells are grown without selection. Expression of a transduced lacZ gene (rAAV/CMVlacZ) is silenced in greater than 90% of cells after 60 days in culture. Surprisingly, hig
The National Academy of Sciences of the USA.
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9. The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells
Oxford University Press.
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10. Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation
We have constructed a stable cell line, human embryonal kidney 293M+, containing a lacZ reporter gene controlled by an in vitro methylated hormone-responsive enhancer. Methylation of the enhancer–promoter abolishes lacZ expression controlled by ponasterone A (an analogue of ecdysone). Ponasterone A-induced expression is restored by the short-chain fatty ac
Oxford University Press.
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11. Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation
Virally transduced genes are often silenced after integration into the host genome. Chromatin immunoprecipitation and nuclease sensitivity experiments now demonstrate that silencing of the transgene is characterized by deacetylation of histone H4 lysines and chromatin condensation. Trichostatin A treatment results in dramatic reactivation of gene expression
The National Academy of Sciences.
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12. Dynamic Analysis of Proviral Induction and De Novo Methylation: Implications for a Histone Deacetylase-Independent, Methylation Density-Dependent Mechanism of Transcriptional Repression
Methylation of cytosines in the CpG dinucleotide is generally associated with transcriptional repression in mammalian cells, and recent findings implicate histone deacetylation in methylation-mediated repression. Analyses of histone acetylation in in vitro-methylated transfected plasmids support this model; however, little is known about the relationships am
American Society for Microbiology.