Transferases
Mostrando 1-12 de 281 artigos, teses e dissertações.
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1. Subcellular localisation of FLAG tagged enzymes of the dynamic protein S-palmitoylation cycle of Trypanosoma cruzi epimastigotes
Dynamic S-palmitoylation of proteins is the addition of palmitic acid by zDHHC palmitoyl transferases (PATs) and depalmitoylation by palmitoyl protein thioesterases (PPTs). A putative PAT (TcPAT1) has been previously identified in Trypanosoma cruzi, the etiological agent of Chagas disease. Here we analyse other 14 putative TcPATs and 2 PPTs in the parasite g
Mem. Inst. Oswaldo Cruz. Publicado em: 28/05/2018
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2. Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population
Abstract Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 heal
Genet. Mol. Biol.. Publicado em: 2018-03
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3. A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients
Abstract: Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Eg
An. Bras. Dermatol.. Publicado em: 2018-02
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4. Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet
Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effect
Braz J Med Biol Res. Publicado em: 30/11/2017
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5. The Role of the Conformational Dynamics of Glutathione S-Transferase Epsilon Class on Insecticide Resistance in Anopheles gambiae
Glutathione S-transferases (GSTs) are enzymes capable of metabolizing cytotoxic compounds. The enzyme AgGSTE2, member of epsilon class GSTs (GSTE), is the most important GST conferring resistance to dichloro-diphenyl-trichloroethane (DDT) in Anopheles gambiae. We have investigated the conformational dynamics of three GSTE variants (GSTE2, GSTE2-I114T/F120L,
J. Braz. Chem. Soc.. Publicado em: 2016-09
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6. THE PHENOLIC COMPOSITION OF THE HEPATOPROTECTIVE AND ANTIOXIDANT FRACTIONS OF Albizia lebbeck L.
An investigation of the hepatoprotective and antioxidant activities of the chloroform, ethyl acetate and n-butanol fractions of the leaves of Albizia lebbeck L. was performed. The first two fractions expressed the best results regarding the suppression of the increased levels of plasma amino-transferases and alkaline phosphatase in liver-damaged mice (after
Quím. Nova. Publicado em: 2016-09
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7. Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation
The aim of this study was to develop a theoretical model using Anopheles gambiae GSTE2 structure as template for Aedes aegypti GSTE2 by homology modeling Docking simulations were performed for both the enzymes against usnic acid in neutral and anionic forms. Ramachandran plot revealed that 93.9% of the GSTE2 model residues were located on most favored region
Braz. arch. biol. technol.. Publicado em: 2014-10
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8. Nulidade de GSTT1/GSTM1 relacionada a pesticidas associa-se com doenca de Parkinson
Fatores genéticos e ambientais influenciam a patogênese da doença de Parkinson (DP). Variantes genéticas das enzimas glutationa S-transferases (GST) parecem estar envolvidas com a doença. Os objetivos deste estudo foram avaliar a influência de variantes genéticas de GST (GSTT1/GSTM1) e sua associação com
Arq. Neuro-Psiquiatr.. Publicado em: 2013-08
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9. Polimorfismos GSTM1, GSTT1 e GSTP1, fatores de risco para câncer de mama e densidade mamográfica em mulheres submetidas a rastreamento mamográfico
Polimorfismos genéticos em genes relacionados com o metabolismo de xenobióticos, como os genes da superfamília das glutationa S-transferases (GSTM1, GSTT1 e GSTP1) têm sido associados com o aumento do risco para câncer de mama (CM). Considerando a alta incidência de CM na cidade de Porto Alegre, região Sul do Brasil, a proposta deste estudo foi caract
Rev. bras. epidemiol.. Publicado em: 2012-06
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10. Influência do Gene pacC na Regulação de Manosiltransferases no Dermatófito Trichophyton rubrum em Função de Variações Nutricionais e pH Ambiente. / Influence of Gene pacC in Mannosiltransferase Regulation of the Dermathophyte Trichophyton rubrum in Function to Changes by pH and Nutrient Sources.
Gene expression regulation is essential for fungi to adapt to environmental adversities, such as changes in the extracellular pH, nutrient starvation, ionic strength, and temperature. The adaptive response to ambient pH is well characterized in model fungi such as Aspergillus nidulans, and involves the signal transduction pathway consisting of the products o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/12/2011
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11. Os Genes Codificadores de Glutationa S-transferases na Abelha Apis mellifera: Expressão, Regulação e Função Durante e Após a Metamorfose. / The genes Encoding Glutathione S-transferases in the Honeybee (Apis mellifera): expression, regulation and function during and After Metamorphosis.
Em insetos, as enzimas glutationa S-transferases (GSTs) são conhecidas pela capacidade de degradar inseticidas, pesticidas e outros compostos químicos, naturais ou não naturais, estranhos ao organismo, podendo também promover o transporte intracelular de hormônios, metabólitos, e atuar na proteção celular contra o estresse oxidativo. Além disto, a f
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/10/2011
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12. Adenina fosforibosiltransferase de Schistosoma mansoni: proposta de detalhamento do mecanismo catalítico por dinâmica molecular / Adenine phosphoribosyltransferase from Schistosoma mansoni: insights into the catalytic mechanism via molecular dynamics
A Adenina Fosforibosiltransferase (APRT E.C. 2.4.2.7) pertence à família de enzimas Fosforibosil Transferases (PRTase) do Tipo I , que catalisa a conversão reversível de Adenina e 5-fosfo-α-D-ribose-1-difosfato (PRPP) em difosfato e adenosina monofosfato, um importante precursor energético da célula. A APRT integra a via de salvação de purinas,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/08/2011