Toxicity To Drugs
Mostrando 1-12 de 362 artigos, teses e dissertações.
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1. Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded
Quím. Nova. Publicado em: 2020-06
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2. Drug-induced nephrotoxicity
RESUMO A lesão renal aguda é um diagnóstico muito comum, presente em até 60% dos pacientes críticos, e sua terceira maior causa é a toxicidade de medicamentos. A nefrotoxicidade pode ser definida como qualquer lesão renal causada por medicamentos, direta ou indiretamente, tendo a insuficiência renal aguda, tubulopatias e glomerulopatias como apresent
Rev. Assoc. Med. Bras.. Publicado em: 13/01/2020
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3. SÍNTESE, ATIVIDADE ANTILESHMANIA E CITOTÓXICA DE HIDRAZONAS DERIVADAS DE ALDEÍDOS NATURAIS
Leishmaniasis is endemic anthropozoonosis considered to be a severe public health problem. The treatment with pentavalent antimonials presents high toxicity motivating the search for effective and less toxic drugs. Hydrazones and N-acylhydrazones are functional groups that are prominent in Medicinal Chemistry, including as antiprotozoals. In this context, fi
Quím. Nova. Publicado em: 2020-01
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4. Essential Oils from Croton Species: Chemical Composition, in vitro and in silico Antileishmanial Evaluation, Antioxidant and Cytotoxicity Activities
Chemotherapy treatment of leishmaniasis is based on the use of pentavalent antimonials, but these drugs present low efficacy and high toxicity. In the search for new antileishmanial agents, essential oils (EOs) from four Croton species (C. argyrophylloides, C. jacobinensis, C. nepetifolius and C. sincorensis) were evaluated against Leishmania infantum chagas
J. Braz. Chem. Soc.. Publicado em: 24/10/2019
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5. Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil
Resumo O Cerrado brasileiro possui diversas espécies botânicas com fins medicinais utilizadas por comunidades tradicionais e muitas dessas plantas não estão incluídas na lista do Programa de Pesquisa de Plantas Medicinais da Central de Medicamentos. O objetivo deste estudo foi a triagem fitoquímica e o bioensaio toxicológico frente ao Brine shrimp L.
Braz. J. Biol.. Publicado em: 21/10/2019
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6. Retinal exams requested at Primary Care Unit: indications, results and alternative strategies of evaluation
RESUMO Objetivo Avaliar as indicações, os resultados e a estratégia de exames de retina solicitados em Unidades Básicas de Saúde. Métodos Estudo retrospectivo no qual foram analisados as indicações e os resultados de exames de retina, nas modalidades mapeamento de retina e retinografia. Em casos de boa acuidade visual e sintomas oculares ausentes,
Einstein (São Paulo). Publicado em: 16/09/2019
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7. American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
Abstract: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acu
An. Bras. Dermatol.. Publicado em: 29/07/2019
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8. A randomized, open-label clinical trial comparing the long-term effects of miltefosine and meglumine antimoniate for mucosal leishmaniasis
Abstract INTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route of administration of standard drugs. Miltefosine is an oral agent used for leishmaniasis treatment; however, no data exist regarding its use for ML in Brazil. In this study, we aimed to evaluate the efficacy of miltefosine for ML treatment compared
Rev. Soc. Bras. Med. Trop.. Publicado em: 28/03/2019
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9. Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases
Abstract Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei respectively. These d
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/02/2019
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10. Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology
Abstract Toona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discusse
Rev. bras. farmacogn.. Publicado em: 2019-02
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11. Process Evaluation of Sugar-Based Polymeric Colloidal Nanocarrier Formation
Abstract Several studies have demonstrated that sugar-based nanocarriers are recommended to develop drug delivery systems since they are biocompatible and biodegradable and might improve the therapeutic index of currently used drugs by reducing their toxicity and enhancing their bioavailability. Therewith, this work studied the processing conditions to forma
Mat. Res.. Publicado em: 31/01/2019
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12. Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
Olanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We,
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018