Thyroxine Binding Globulin
Mostrando 13-24 de 57 artigos, teses e dissertações.
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13. FAMILIAL INCREASE IN THE THYROXINE-BINDING SITES IN SERUM ALPHA GLOBULIN*
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14. Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine.
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15. THYROXINE BINDING CAPACITY OF SERUM ALPHA GLOBULIN IN HYPOTHYROID, EUTHYROID, AND HYPERTHYROID SUBJECTS 1
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16. Stability of thyroxine and triiodothyronine in biological fluids.
The stability of thyroxine and triiodothyronine in serum has been investigated. Apparent levels of total thryroxine, as determined by two different protein-binding assays employing thyroxine-binding globulin as the binding protein, increased significantly in serum and plasma samples stored at room temperature and were signficantly lower in haemolysed samples
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17. CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE-BINDING GLOBULIN OF PLASMA*
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18. Effect of thyroid-suppressive doses of triiodothyronine on thyroxine turnover and on the free thyroxine fraction
The relationship between free thyroxine concentration and thyroxine turnover was studied during thyroid suppression with triiodothyronine. Although there was some increase in the proportion of serum thyroxine bound to thyroxine-binding globulin, the ratio of ultrafilterable to protein-bound hormone was not significantly affected. The fractional disappearance
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19. Studies on Human Thyroxine-Binding Globulin: VI. THE NATURE OF SLOW THYROXINE-BINDING GLOBULIN
A model system utilizing a highly purified partially desialylated thyroxine-(T4) binding protein (STBG) was studied. STBG was prepared by the same affinity chromatographic method we have reported for preparation of highly purified T4-binding globulin (TBG). The necessary prerequisite for preparation of STBG was the use of T4-substituted Sepharose which had b
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20. Evaluation of new kits for the assessment in vitro of thyroid function by determination of serum total thyroxine, free TBG capacity, and free thyroxine index using Sephadex G-25 and 125I-labelled triiodothyronine and thyroxine
A trial was carried out on 134 patients of new kits (Ames Co) using columns of Sephadex G-25 for the determination of serum total thyroxine (Tetralute test) and for the indirect estimation of serum free thyroxine-binding globulin capacity (Trilute test). Both new methods were quicker and easier than the reference resin methods and of similar precision. The t
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21. Preparation and Properties of Thyroxine-Binding Alpha Globulin (TBG)
Thyroxine-binding alpha globulin (TBG) in human serum was isolated from Cohn fractions IV-5,6 and IV-4 by (1) chromatography on carboxymethyl (CM) cellulose, (2) gel filtration on Sephadex G-200, (3) chromatography on diethylaminoethyl-Sephadex, (4) a novel procedure of “double-gel” electrophoresis, and (5) preparative polyacrylamide gel electrophoresis.
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22. The distribution kinetics of triiodothyronine: studies of euthyroid subjects with decreased plasma thyroxine-binding globulin and patients with Graves' disease
The kinetics of distribution of 3,3′,5-triiodo-L-thyronine (T3) have been studied employing both a single-injection and a continuous infusion of T3-131I. External monitoring of radioactivity in the liver during the infusion permitted estimation of the hepatic distribution volume (VH) and the one-way hepatic clearance (CH) of the hormone. Among 10 euthyroid
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23. Studies on human thyroxine-binding globulin (TBG): I. Purification of TBG and immunologic studies on the relationship between TBG from normal persons and those with TBG “deficiency”
A method for obtaining highly purified thyroxine-binding globulin (TBG) from whole human serum is presented. The method employs relatively simple procedures of step-wise ammonium sulfate precipitation followed by column chromatography on DEAE cellulose and DEAE Sephadex. The final product produces a single protein band on disc electrophoresis. The sedimentat
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24. Observations on the Nature of the Underlying Disorder and the Occurrence of Associated Plasma Transport Abnormalities in a Patient with an Idiopathic Increase in the Plasma Thyroxine-binding Globulin*