Thromboxane
Mostrando 1-12 de 280 artigos, teses e dissertações.
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1. The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits with acute massive pulmonary embolism
Abstract Purpose: To investigate changes in the plasma concentrations of cardiac troponin I (CTnI), thromboxane A2 (TXA2), prostaglandin I2 (PGI2) and endothelin-1 (ET-1) in rabbits with massive pulmonary embolism (AMPE) and the impact of nitric oxide inhalation (NOI) on these indices. Methods: A total of 30 Japanese rabbits were used to construct an MPE
Acta Cir. Bras.. Publicado em: 2018-07
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2. Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits
Abstract Purpose: To investigate the influence of dexmedetomidine on myocardial ischemia-reperfusion injury (IRI) in rabbits. Methods: Twenty-four New Zealand white rabbits were randomly divided into two equal-sized groups: IRI group (group IR) and dexmedetomidine group (group D). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate
Acta Cir. Bras.. Publicado em: 2018-01
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3. Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update
The endothelium plays a vital role in maintaining circulatory homeostasis by the release of relaxing and contracting factors. Any change in this balance may result in a process known as endothelial dysfunction that leads to impaired control of vascular tone and contributes to the pathogenesis of some cardiovascular and endocrine/metabolic diseases. Reduced e
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09
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4. Volume replacement with lactated ringers or 3% hypertonic saline solution during combined experimental hemorrhagic shock and traumatic brain injury / Estudo da reposição volêmica inicial em modelo experimental de choque hemorrágico associado ao traumatismo craniencefálico: comparação entre as soluções de ringer lactado e salina hipertônica 3%
The devastating effects of hypotension on head-trauma-related mortality are well known. This study evaluates the systemic and cerebral hemodynamic responses to volume replacement with 3% hypertonic saline (HSS) or lactated Ringers solution (LR), during the acute phase of hemorrhagic shock (HS) associated with traumatic brain injury (TBI). METHODS: Fifteen mo
Publicado em: 2007
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5. The supplementation with fatty poliinsaturated omega-3 acids reduced the plasmatic concentration of pro-inflammatory eicosanoids of the lactate desidrogenase enzyme and muscular lesions in rats submitted to sessions of swimming. / A suplementação com acidos graxos polinsaturados omega-3 reduziu a concentração plasmatica de eicosanoides pro-inflamatorios, da enzima lactato desidrogenase e de lesões musculares em ratos submetidos a sessões de natação.
The use of antiinflammatory drugs is common among athletes in which the prevalence of muscular lesions is elevated in training and competition periods. However, some of those drugs have an immunosuppression action, and when used in high dosages or for long time can provoke a decrease in the immunological responses. The objective of the present Thesis was to
Publicado em: 2007
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6. Ativação plaquetária em formas clínicas distintas da doença arterial coronariana (papel da P-selectina e de outros marcadores nas anginas estável e instável)
OBJETIVO: Os marcadores da ativação plaquetária em geral se apresentam elevados na doença arterial coronariana. Desse modo, procuramos identificar a presença e as potenciais associações de diferentes marcadores da ativação plaquetária. MÉTODOS: Estudamos pacientes com angina instável (n=28), pacientes com angina estável (n=36) e pacientes sem do
Arquivos Brasileiros de Cardiologia. Publicado em: 2006-10
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7. Prostanoids modulate inflammation and alloimmune responses during graft rejection
Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allog
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-12
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8. Hipertensão pulmonar experimental em cães anestesiados : papel da endotelina-1 e do tromboxano A2, e reversão pelo oxido nitrico inalatorio
ln this study we investigated the pharmacological mechanisms underlying the pulmonary hypertension induced by the protamine-heparin complex in anaesthetized dogs. The animais were anaesthetized with pentobarbital sodium (Hypnoi, 30 mg/kg, i.v). Anaesthesia was maintained with a combination of fentanyl citrate (0.01 mg/kg/h, i.v) and diazepam (0.25 mg/kglh, i
Publicado em: 2002
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9. Estudo comparativo da reatividade vascular em tabagistas, diabeticos e hipertensos
Cigarette smoking, non-insulin-dependent diabetes mellitus and essential hypertension are stablished risk factors for atherosclerosis and premature cardiovascular disease. Heavy smokers, uncompensated diabetics and patients with uncontrolled essential hypertension show impaired arterial vasodilatation which results ftom endothelial dysfunction, a key factor
Publicado em: 2000
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10. Estudo da trombose pulmonar causada pela peçonha da cascavel sul-americana (Crotalus durissus) e suas frações
Convulxin is a high molecular weight, non-enzymatic, platelet aggregating protein present in the venom of South American rattlesnake, Crotalus durissus terrificus. In this work, we investigatd the ability of convulxin to cause pulmonary thrombosis in mice after intravenous injection and examined the possible mechanism (s) involved using specific inhibitors.
Publicado em: 1999
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11. Efeitos do oxido nitrico inalatorio em cães submetidos a embolia aerea
Inhaled nitric oxide (NO) has been used in cases of pulmonary hypertension. Experimental studies have suggested therapeutic effects of NO after pulmonary microembolism. The protective effects of NO inhalation before a massive pulmonary air embolism (PAE) were evaluated in a first study. A second study focused the therapeutic effects of NO inhalation during a
Publicado em: 1998
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12. Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs.
Generation of reactive oxygen metabolites, thromboxane increases, and vasoconstriction have been implicated in the pathogenesis of acute edematous lung injury, such as that seen in patients with the Adult Respiratory Distress Syndrome (ARDS), but their interactions are unknown. We hypothesized that reactive O2 products would stimulate arachidonic acid metabo