Thioperamide
Mostrando 1-8 de 8 artigos, teses e dissertações.
-
1. Low-dose thioperamide injected into the cerebellar vermis of mice immediately after exposure to the elevated plus-maze impairs their avoidance behavior on re-exposure to the apparatus
The present study investigated the effect of thioperamide (THIO), an H3 histaminergic receptor antagonist, microinjected into the cerebellar vermis on emotional memory consolidation in male Swiss albino mice re-exposed to the elevated plus-maze (EPM). We implanted a guide cannula into the cerebellar vermis using stereotactic surgery. On the third day after s
Braz J Med Biol Res. Publicado em: 06/11/2013
-
2. L-histidine enhances learning in stressed zebrafish
The aim of the present study was to determine the effect of the histaminergic precursor L-histidine and the H3 receptor antagonist thioperamide on the learning process of zebrafish submitted or not to confinement stress. On each of the 5 consecutive days of experiment (D1, D2, D3, D4, D5), animals had to associate an interruption of the aquarium air supply w
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
-
3. Efeitos da L-histamina e de antagonistas histaminérgicos sobre a recuperação funcional após hemilabirintectomia em Carassius auratus.
O objetivo deste estudo foi verificar os efeitos da histamina sobre o processo de recuperação funcional, após hemilabirintectomia em peixes da espécie Carassius auratus. Para tanto, foram utilizados a L-histidina, um precursor histaminérgico e antagonistas dos receptores H1, H2 e H3, sendo a clorfeniramina, antagonista H1, a zolantidina antagonista H2 e
Publicado em: 2006
-
4. Histamine H3-receptor activation augments voltage-dependent Ca2+ current via GTP hydrolysis in rabbit saphenous artery.
1. Actions of histamine on the voltage-dependent Ba2+(Ca2+) currents (IBa, ICa) were investigated using the whole-cell patch-clamp technique on dispersed smooth muscle cells from the rabbit saphenous artery. 2. Histamine (half-maximal dose, EC50 = 530 nM) augmented the IBa evoked by a brief depolarizing pulse (100 ms duration; to +10 mV from a holding potent
-
5. Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype
Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. To date, four histamine receptors have been identified, and the H3 receptor, which was recently cloned, is predominantly expressed in the CNS. The peripheral functions of histamine have been investigated intensively using available molecular and pharmacological
American Society for Clinical Investigation.
-
6. Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: A novel protective mechanism in myocardial ischemia
In myocardial ischemia, adrenergic nerves release excessive amounts of norepinephrine (NE), causing dysfunction and arrhythmias. With anoxia and the concomitant ATP depletion, vesicular storage of NE is impaired, resulting in accumulation of free NE in the axoplasm of sympathetic nerves. Intraneuronal acidosis activates the Na+/H+ exchanger (NHE), leadi
The National Academy of Sciences.
-
7. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings
Activation of presynatic histamine H3 receptors (H3R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and ischemic conditions. Analogous to the effects of α2-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, H3R-mediated antiexocytotic effects could result from a decrease
The National Academy of Sciences.
-
8. Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro.
1. The effects of histamine on excitatory synaptic transmission in the dentate gyrus region of rat hippocampal slices were examined using extracellular and whole-cell patch-clamp recording techniques. The GABAA receptor antagonist picrotoxin (50 microM) was present in the bath in all experiments. 2. Histamine (0.7-70 microM) reversibly depressed field excita