Thiazolidinediones
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Ability of two new thiazolidinediones to downregulate proinflammatory cytokines in peripheral blood mononuclear cells from children with asthma
Allergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidi
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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2. Efeitos metabÃlicos in vivo de derivados Benzilideno-Tiazolidinadionas
Thiazolidinediones are insulin-sensitizing agents that working by binding to PPAR-γ, which leads to alteration in the expression of key regulators of lipid homeostasis, glucoregulatory and insulin resistance gene. In this study, it was evaluated the effect of treatment with novel benzylidene thiazolidinediones (BTZDs) derivatives: 5-(4-chlorobenzylidene
Publicado em: 2009
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3. Medium chain fatty acids like PPAR ligand / Ácidos graxos de cadeia média como ligantes da proteína PPAR
PPARs (peroxisome proliferator activated receptors) are nuclear receptors that regulate glucose and fat metabolism, adipogenesis and macrophage polarization and mediate actions of a major class of drugs that are used to treat type 2 diabetes, the thiazolidinediones. While TZDs reduce blood glucose and improve insulin sensitivity effectively, they can also ex
Publicado em: 2009
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4. Rosiglitazone may induce renal injury in normal rats but not in hypercholesterolemic rats / Rosiglitazone pode causar lesão tubular renal em ratos normais mas não em ratos hipercolesterolêmicos
Introdução: Rosiglitazone (RGL) é um ligante dos receptores PPAR e vem sendo usada no tratamento do Diabetes Mellitus tipo 2 e nas doenças inflamatórias. Mas, RGL pode reduzir a filtração glomerular (FG), a carga excretada de sódio na urina (UVNa) e aumentar a expressão da Na+,K+- ATPase na medula renal. Então, RGL pode causar edema e insuficiênci
Publicado em: 2009
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5. Chalcona como modelo de estudo no receptor ativado por proliferador peroxissomal (PPAR)
Peroxisome proliferators-activated receptors (PPAR) are genes regulators of important physiological processes, such as glucose homeostasis and inflammatory processes. Therefore, the development of ligants which behave as agonist for PPAR, have special interest in the research of the treatment of illnesses such as diabetes mellitus, dislypidemia and arteriosc
Publicado em: 2008
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6. Síntese e avaliação farmacológica de derivados fenóxi-acetoacetatos em receptores ativadados por proliferadores peroxissomais e em receptores de hormônio tireoideano
Nuclear receptors (NRs) are of great importance for the worldwide drug market since they are involved in mechanisms which influence several diseases that affect humanity like, for instance, diabetes mellitus (DM2), obesity, dislypemia and atherosclerosis. Peroxisome Proliferator-Activated Receptors (PPAR) and Thyroid Hormone Receptors (TR) control important
Publicado em: 2008
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7. Characterization of genes and serum proteins related to type 2 diabetes mellitus in patients treated with pioglitazone / Caracterização de genes e proteínas plasmáticas relacionadas ao diabetes melito do tipo 2 em indivíduos tratados com pioglitazona
The diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, the result from insulin secretion or action deficiency, or both. Pioglitazone is an oral hypoglycemic drug, included in the class of thiazolidinediones, which work by binding to nuclear receptors PPARY nuclear what improve the state of resistance to insulin. Pioglitazone m
Publicado em: 2008
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8. Effect of pioglitazone on the functional viability and apoptosis rate of culture murine pancreatic islets. / Efeito da pioglitazona sobre a viabilidade funcional e o índice de apoptose de ilhotas pancreáticas murídeas em cultura
Acredita-se que a diminuição progressiva da massa de células observada durante a evolução do diabetes mellitus tipo 2 (DM 2) ocorra por apoptose deste tipo celular. As tiazolidinedionas (TZDs), uma classe de medicamentos utilizada no tratamento do DM 2, atuam como ligantes dos receptores ativados por proliferadores de peroxissomos (PPAR) e e promovem di
Publicado em: 2008
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9. Efeitos da rosiglitazona sobre marcadores de risco cardiovascular e função da celula beta em diabeticos tipo 2 virgens de tratamento / Rosiglitazone effects on cardiovascular risk markers and beta cell function in drug naive type 2 diabetic patients
A principal causa de mortalidade entre os portadores de Diabetes tipo 2 é a doença cardiovascular. Estudos têm cada vez mais procurado alterações inerentes ao diabetes tipo 2 que justifiquem a maior incidência de doença cardiovascular nesse grupo. A presença de resistência à insulina, redução de adiponectina, aumento de PCR, disfunção endotelia
Publicado em: 2007
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10. SÃntese, modelagem molecular e atividade hipoglicemiante de novas arilideno-tiazolidinadionas
The glitazones, also referred to as insulin sensitizers, are generically a class of thiazolidinediones (TZDs) that possess hypoglycemic activity and are orally administered in patients with type II diabetes mellitus. Two of these thiazolidinediones are rosiglitazone and pioglityazone. We synthesized 12 arylideno-thiazolidinediones (ATZDs) of 5-benzylideno-3-
Publicado em: 2006
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11. Type 2 diabetes, thiazolidinediones, and cardiovascular risk
Type 2 diabetes is a common disorder with an increased risk of macrovascular complications. Achieving adequate glycaemic control is an important aim of therapy. Thiazolidinediones, or glitazones, have been used for the treatment of diabetes for a decade. Rosiglitazone and pioglitazone are currently available, however recent concerns around cardiovascular saf
Royal College of General Practitioners.
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12. Heart failure associated with thiazolidinediones doesn't reduce survival
BMJ Publishing Group Ltd..