Theta Model
Mostrando 13-24 de 37 artigos, teses e dissertações.
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13. Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease ▿
We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reduct
American Society for Microbiology (ASM).
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14. Asymmetries of oxygen uptake transients at the on- and offset of heavy exercise in humans.
1. At work rates which do not result in a sustained increase in blood lactate ([L-]), oxygen uptake (VO2) approaches the steady state with first-order kinetics. However, when [L-] is increased, at least two kinetic components are required to characterize the VO2 response dynamics. The purpose of the present investigation was to determine whether these more-c
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15. Kinetics and thermodynamics of folding in model proteins.
Monte Carlo simulations on a class of lattice models are used to probe the thermodynamics and kinetics of protein folding. We find two transition temperatures: one at T theta, when chains collapse from a coil to a compact phase, and the other at Tf (< T theta), when chains adopt a conformation corresponding to their native state. The kinetics are probed by s
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16. Spatial-area selective retrieval of multiple object–place associations in a hierarchical cognitive map formed by theta phase coding
The human cognitive map is known to be hierarchically organized consisting of a set of perceptually clustered landmarks. Patient studies have demonstrated that these cognitive maps are maintained by the hippocampus, while the neural dynamics are still poorly understood. The authors have shown that the neural dynamic “theta phase precession” observed in t
Springer Netherlands.
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17. Evolution and maintenance of quantitative genetic variation by mutations.
The genotypic variance within, sigma 2w, and between, sigma 2b, random mating populations and rates and times for convergence to equilibrium values from different founder populations are formulated for an additive genetic model with an arbitrary number of alleles k, number of loci m, population size N, and mutation rate u, with unequal mutation rates for all
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18. Absence of linkage between familial neural tube defects and PAX3 gene.
Neural tube defects (NTD) are among the most common and disabling birth defects. The aetiology of NTD is unknown and their genetics are complex. The majority of NTD cases are sporadic, isolated, nonsyndromic, and generally considered to be multifactorial in origin. Recently, PAX3 (formerly HuP2, the human homologue of mouse Pax-3), on chromosome 2q35-37, was
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19. LTD windows of the STDP learning rule and synaptic connections having a large transmission delay enable robust sequence learning amid background noise
Spike-timing-dependent synaptic plasticity (STDP) is a simple and effective learning rule for sequence learning. However, synapses being subject to STDP rules are readily influenced in noisy circumstances because synaptic conductances are modified by pre- and postsynaptic spikes elicited within a few tens of milliseconds, regardless of whether those spikes c
Springer Netherlands.
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20. Removal of periaxonal potassium accumulation in a squid giant axon by outward osmotic water flow.
1. Periaxonal potassium accumulation does not occur in a squid giant axon when outward water flow is maintained by an osmotic gradient across the axolemma. Potassium concentrations in the periaxonal space were calculated from the potassium potentials (EK) for the tail K+ current. With outward water flow, the periaxonal K+ concentration was maintained at valu
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21. Conformational analysis of polynucleotides. I. The favorable left-handed helical model for the poly(8,2'-S-cycloadenylic acid) with high anti conformation.
1) Energy calculations have shown that poly (8,2'-S-cycloadenylic aicd) can form left-handed helices owing to the high anti conformation. 2) Two favorable left-handed helices are characterized by axial translation per residue (Z=4.3 and 3.6A) and by rotations per residue (theta= 40 degrees and -25 degrees). 3) The proposed helical models might be stable in a
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22. Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH.
The membrane of tissue-cultured chick pectoral muscle contains an ionic channel which is activated by membrane tension. With 150 mM-external K+ and 150 mM-internal Na+, the channel has a conductance of 70 pS and a reversal potential of +30 mV. With 150 mM-external Na+ and 150 mM-internal K+ (normal gradient) the channel has a conductance of 35 pS and a rever
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23. Pharmacodynamic modeling of the in vivo interaction between cefotaxime and ofloxacin by using serum ultrafiltrate inhibitory titers.
The pharmacokinetics (PK) and pharmacodynamics (PD) of cefotaxime and ofloxacin and of their combination were examined in a three-period randomized crossover study involving 12 healthy adults. The PK of cefotaxime and ofloxacin were modeled. PD was assessed from the predicted concentrations in serum and serum untrafiltrate inhibitory titers for 10 test organ
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24. Conformation of sulfoquinovosyldiacylglycerol bound to a magnetically oriented membrane system.
The conformation of uniformly 13C-labeled sulfoquinovosyldiacylglycerol (SQDG) is studied in both membrane and solution environments using NMR spectroscopy. Analysis in a membrane-like environment is based on the measurement of dipolar interactions between 13C-13C and 1H-13C spin pairs and on the measurement of 13C chemical shift anisotropy offsets, which ap