Therapeutics Effects
Mostrando 1-12 de 86 artigos, teses e dissertações.
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1. The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics
Social anxiety disorder (SAD) is a highly prevalent psychiatric disorder that presents with an early age of onset, chronic disease course, and increased risk of psychiatric comorbidity. Current treatment options for SAD are associated with low response rates, suboptimal efficacy, and possible risk of adverse effects. Investigation of new neurobiological mech
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. Therapeutics in Radiation-induced Proctopathy: A Systematic Review
Abstract Malignant neoplasms are increasingly prevalent in the daily clinical practice. Up to 61% of patients with pelvic malignancies undergo pelvic radiotherapy in different doses, which may cause intestinal damage, and the rectum is the segment most frequently affected due to its fixed position in the pelvis. Currently, there are several strategies to min
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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4. Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide to
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 03/06/2019
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5. Estrogen and progesterone promote breast cancer cell proliferation by inducing cyclin G1 expression
Breast cancer is the most common cause of cancer among women in most countries (WHO). Ovarian hormone disorder is thought to be associated with breast tumorigenesis. The present study investigated the effects of estrogen and progesterone administration on cell proliferation and underlying mechanisms in breast cancer MCF-7 cells. It was found that a single ad
Braz J Med Biol Res. Publicado em: 01/03/2018
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6. Artemisia annua increases resistance to heat and oxidative stresses, but has no effect on lifespan in Caenorhabditis elegans
Abstract It is suggested that oxidative stress induced by cellular reactive oxygen species is one of the major causal factors of aging. The effect of dietary supplementation of anti-oxidants on response to environmental stressors and lifespan has been studied in various model organisms. In the present study, we examine the effect of Artemisia annua extract o
Food Sci. Technol. Publicado em: 31/05/2016
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7. The clinical effectiveness of pegylated interferon and ribavirin for the treatment of chronic hepatitis C in HIV-infected patients in Brazil: a multicentric study
Introduction: in Brazil, chronic hepatitis C in patients coinfected with the human immunodeficiency virus (HIV) is treated with pegylated interferon (Peg-IFN) and ribavirin (RBV). However, few studies have evaluated the effectiveness of this treatment in this particular population. The identification of the factors that predict sustained virological respon
Braz J Infect Dis. Publicado em: 2015-02
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8. Biomarkers in mood disorders research: developing new and improved therapeutics
Background Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders. Objective The identification of biomarkers could help develop personalized psychiatric treatments that may impact public health. Methods These biomarkers, which are
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2014
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9. Preparation of poly(urethane-urea) nanoparticles containing açaí oil by miniemulsion polymerization
Polyurethane nanoparticles (NPs) are promising candidates for the controlled and targeted delivery of therapeutics in a variety of biomedical applications. In this work, a report is made of NPs produced by miniemulsion polymerization with isophorone diisocyanate (IPDI) and castor oil, glycerol, and poly(ethylene glycol) (PEG) with molar masses 400 and 1000 a
Polímeros. Publicado em: 27/08/2013
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10. Herbal medicines: old and new concepts, truths and misunderstandings
Men have been using herbal medicines for thousands of years. The advantages of this type of therapeutics include good availability, local cultural aspects, individual preferences, the increasing demand for natural and organic products, and the already validated synergistic effects of herbal medicines. However, ethically, the scope and limits of these drugs n
Rev. bras. farmacogn.. Publicado em: 25/02/2013
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11. Efficacy and safety of creatine supplementation combined with exercise training in type II diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial / Eficácia e segurança da suplementação de creatina acompanhada de treinamento físico em diabéticos tipo 2: estudo clínico, randomizado, duplo-cego, controlado por placebo
Some studies have suggested that creatine supplementation may attenuate insulin resistance, but whether this supplement is safe remains uncertain. In light of this, the aim of this trial was to investigate the efficacy and safety of creatine supplementation combined with exercise training in patients with type II diabetes. A randomized, double-blind, placebo
Publicado em: 2010
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12. Atividade Antinociceptiva, em dores agudas, de um novo fator extraído da secreção cutânea de Rhinella jimi (Amphibia Anura) / Antinociceptive activity in acute pain, a new factor extracted from the skin secretion of Rhinella jimi (Amphibia - Anura)
Pain control has been an important focus of health for a long time. The ideal analgesic should be powerful, promoting maximum pain relief, but must submit a minimum adverse symptoms. The opioid agonists are used in treatment of intense acute pains and chronic pains in terminal patients, although they present important side effects, such as constipation, resp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/12/2009