Theory Of Probabilities
Mostrando 25-36 de 45 artigos, teses e dissertações.
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25. Generalized Gap Model for Bacterial Artificial Chromosome Clone Fingerprint Mapping and Shotgun Sequencing
We develop an extension to the Lander-Waterman theory for characterizing gaps in bacterial artificial chromosome fingerprint mapping and shotgun sequencing projects. It supports a larger set of descriptive statistics and is applicable to a wider range of project parameters. We show that previous assertions regarding inconsistency of the Lander-Waterman theor
Cold Spring Harbor Laboratory Press.
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26. Optimal Sampling Schedule Design for Populations of Patients
Generation of pharmacodynamic relationships in the clinical arena requires estimation of pharmacokinetic parameter values for individual patients. When the target population is severely ill, the ability to obtain traditional intensive blood sampling schedules is curtailed. Population modeling guided by optimal sampling theory has provided robust estimates of
American Society for Microbiology.
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27. A Theory Of Attending And Reinforcement In Conditional Discriminations
A model of conditional discrimination performance (Davison & Nevin, 1999) is combined with the notion that unmeasured attending to the sample and comparison stimuli, in the steady state and during disruption, depends on reinforcement in the same way as predicted for overt free-operant responding by behavioral momentum theory (Nevin & Grace, 2000). The rate o
Society for the Experimental Analysis of Behavior.
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28. Quantitative prediction of perceptual decisions during near-threshold fear detection
A fundamental goal of cognitive neuroscience is to explain how mental decisions originate from basic neural mechanisms. The goal of the present study was to investigate the neural correlates of perceptual decisions in the context of emotional perception. To probe this question, we investigated how fluctuations in functional MRI (fMRI) signals were correlated
National Academy of Sciences.
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29. Likelihood ratios for DNA identification.
Likelihood ratio (LR) tests are provided for the three alternatives to DNA identity: exclusion, coincidence, and kinship. The coincidence test uses the radius of coalescence to conserve the observed frequency of single band phenotypes. Genotype probabilities under kinship are derived for mating groups, specified relatives, and structured populations; and unb
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30. Role of Biased Gene Conversion in One-Locus Neutral Theory and Genome Evolution
The implications of biased gene conversion acting on selectively neutral alleles are investigated for a single diallelic locus in a finite population. Even a very slight conversion bias can significantly alter fixation probabilities. We argue that most newly arising mutants will be at a conversion disadvantage, resulting in a potentially greatly decreased su
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31. Population genetic theory of kin selection: Multiple alleles at one locus
Exact population genetic models of one-locus sib-to-sib kin selection with an arbitrary number of alleles are studied. First, a natural additive scaling is established for the genotypic value associated with probabilities of performance of altruism. Two classes of polymorphic equilibria are possible, one corresponding to the usual one-locus viability equilib
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32. Allelic and nonallelic homology of a supergene family.
A model to explain the high degree of polymorphism at the major histocompatibility complex (MHC) is described. The model incorporates domain transfer between the different loci in a supergene family by either gene conversion or double unequal crossing-over. Population genetics theory is used to formulate changes in the probabilities of allelic and nonallelic
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33. On the Theory of Partially Inbreeding Finite Populations. II. Partial Sib Mating
It is assumed that a population has M males in every generation, each of which is permanently mated with c - 1 females, and that a proportion β of matings are between males and their full sisters or half-sisters. Recurrence equations are derived for the inbreeding coefficient of one random individual, coefficients of kinship of random pairs of mates and pro
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34. Probability of founder effect in a tribal population.
When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic theory leaves no doubt this is a possible e
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35. Birds track their Grinnellian niche through a century of climate change
In the face of environmental change, species can evolve new physiological tolerances to cope with altered climatic conditions or move spatially to maintain existing physiological associations with particular climates that define each species' climatic niche. When environmental change occurs over short temporal and large spatial scales, vagile species are exp
National Academy of Sciences.
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36. On the Theory of Partially Inbreeding Finite Populations. I. Partial Selfing
Some stochastic theory is developed for monoecious populations of size N in which there are probabilities β and 1 - β of reproduction by selfing and by random mating. It is assumed that β >> N-1. Expressions are derived for the inbreeding coefficient of one random individual and the coefficient of kinship of two random separate individuals at time t. The